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Biomedical subjects

R Sciot

Publications and source records attributed to R Sciot.

201 records · Page 12Linked to original sources
PubMedDate not supplied

Differential diagnosis and prognosis of cirrhosis: role of liver biopsy.

Histopathological examination of needle biopsies of the liver is a cornerstone in the diagnostic work-up on a patient with symptoms of chronic liver disease. It allows to confirm whether cirrhosis is present or not. In a considerable number of cases, this confirmation is definitive. In some cases, only a diagnostic level of suspicion is reached. In these cases, close collaboration between clinician and pathologist may increase the degree of diagnostic certainty. A reliable diagnosis of cirrhosis on liver biopsies requires careful consideration of differential diagnostic alternatives. Application of the full battery of histopathological techniques, including special stains, polarizing light and immunohistochemistry, allows to specify (or to help to specify) the aetiology in a substantial number of cases. The histopathologist should further look for information which bears on prognosis, and evaluate the stage, the activity and eventual complications by search of the corresponding histological changes.

Biopsy, Needle↗
PubMedDate not supplied

Bronchioloalveolar carcinoma: long-term survival of 23 resected patients.

We studied 23 patients, who underwent resection for bronchioloalveolar carcinoma between 1975 and 1992. The predictive value of the radiologic features, TNM staging, histopathologic type and extent of resection were examined. There were 20 men and 3 women (13%) with a mean age of 58 years (32-72y). Of all patients, 18 (78.3%) were asymptomatic. At chest X-ray, 14 (61%) revealed a solitary nodule, 6 an infiltrative or pneumonic mass, one a cystic lesion, and two multinodular lesions. The actuarial five-year survival was 46 +/- 23%. When a lobectomy was performed for bronchioloalveolar carcinoma, survival was better than when a pneumonectomy was performed. None of the seven patients who underwent a pneumonectomy survived 5 years. The actuarial 5-year survival of the 16 lobectomies was 70 +/- 25%. There was no statistical difference in survival between the histopathologic types.

Adenocarcinoma, Bronchiolo-Alveolar↗