Search PubMed⌕ Search

Biomedical subjects

R Schwarz

Publications and source records attributed to R Schwarz.

At least 145 records · Page 8Linked to original sources
PubMed1991

[Postoperative evisceration].

From 1930 to 1989 postoperative rupture of abdominal wound occurred in 0.42 per cent (n = 82) in the Department of Obstetrics and Gynaecology of the University of Rostock. 60 per cent of the patients were younger than 50 years. Patients of reduced general condition and anaemia were predisposed to this complication. We observed postoperative alterations of the respiratory tract in 13 per cent and alterations of the gastro-intestinal tract in 20 per cent which lead to increased intra-abdominal pressure. We observed postoperative wound rupture only in 8 cases after Pfannenstiel's incision, but all other times after median section, predominantly during the 7th and 12th postoperative day. All patients were treated by secondary suture, immediately. 8 patients came to death, three of them had no direct link to wound rupture. For prophylaxis the use of non-absorbable suture material, safety sutures, intraoperative blood and protein substitution and prevention of affections of the respiratory system and gastrointestinal tract are recommended.

Female↗
PubMed1991

[Microscopic studies of the skin of the Turkish angora goat. II. Functional morphology of the hair follicle].

The study supplies a detailed description of the development, morphology and function of anagen hair follicles in the Turkish Angora goat. In this connection, the formation of the hair root and the epithelial root sheaths is of specific interest. Furthermore, the intensive structural alterations and disintegrative processes occurring during the catagen phase are presented. The telogen hair follicle development is also referred to with special regard to typical structural and functional features.

Animals↗
PubMed1990

[Therapy costs at the hospital].

The inflation in hospital financing has fallen off. The new regulations brought in with the health reform law (Gesundheitsreformgesetz) could help to cut hospital running costs and lead to a more economical form of medical treatment. At present a prognosis of these cost reductions is not possible. The new list of charges for medical treatment (Bundespflegesatzverordnung) brought in by the government in 1986 also has helped in reducing expenditures. Especially the requirement for self-budgeting and performance-costing has lead to a reduced inflation rate in medical treatment costs. An effective control of medical treatment costs demands more management not only in administrative but also in medical areas as well. Improving hospital economy must not automatically lead to a reduction in the quality of the service provided.

Cost Control↗
PubMed1990

Fine needle aspiration cytology in the evaluation of head and neck masses.

One hundred eighty-two fine needle aspirations (FNAs) of head and neck masses performed between the years 1981 and 1987 were studied retrospectively. Seventeen FNAs were unsatisfactory. Of the remaining 165, 148 (90%) were followed up with either surgery or clinical follow-up of at least 12 months' duration. Seventy-one of these aspirates were malignant. Fifty-six cases of metastatic carcinoma and 13 cases of lymphoma were diagnosed. The positive predictive value for metastatic carcinoma and lymphoma was 100%, and the sensitivities were 92% and 100%, respectively. For benign salivary gland lesions, the positive predictive value was 94%, whereas for malignant lesions it was 100%. One case of carcinoma ex-pleomorphic adenoma was missed by FNA. No complications were associated with FNA. We conclude that FNA is a safe and accurate technique, well suited to the in-office evaluation of neck masses of differing causes.

Biopsy, Needle↗
PubMed1990

Chemotherapy of metastatic soft tissue sarcoma with a combination of adriamycin and DTIC or adriamycin and ifosfamide.

Between 1982 and 1986, 38 patients with soft tissue sarcomas were treated with a combination of ADM/DTIC (group A), another 45 (group B) received ADM/IFO between 1986 and 1990. Clinical characteristics were comparable in both groups. Remission rate was 34% in group A and 43% in group B. Duration of remission was 10 months and median survival 13 months in both groups. Toxicity, especially myelotoxicity, was severe without marked differences between both groups. We conclude that adriamycin/DTIC and adriamycin/ifosfamide are both active regimens in metastatic soft tissue sarcomas, nevertheless, overall prognosis remains poor.

Adolescent↗
PubMed1990

Chromophobic cells and their role in extracellular transport of hormones in the bovine adenohypophysis (pars distalis).

Chromophobic cells form sheaths around secretory cells. They are in close contact with them, but occasionally leave open intercellular spaces bounded by desmosomes. It is suggested that 1. there is a reduced exposure of secretory cells to direct negative feedback exerted by hormone discharge of neighbouring cells--especially those of the same cell type, 2. chromophobic cells contribute to the formation of intralobular pathways for extracellular hormone transport.

Animals↗
PubMed1990

[Choice of the surgical route in hysterectomy].

At the Department of Obstetrics and Gynaecology of the University of Rostock there were no significant differences in morbidity and mortality in 2,811 abdominal hysterectomies and 2,030 vaginal ones in the years from 1970 to 1989, but the recovery of the patients after vaginal hysterectomy is better because of the intact abdominal wall. Therefore the vaginal route should be favoured if local conditions allow this.

Female↗
PubMed1990

[Secondary malignomas following radiotherapy of breast carcinoma: a case report].

Numerous cases of radiation-induced malignoma have been described, where the radiation osteosarcomas are placed in the foreground. In this article a case of a female patient is described who developed not only a radiation-induced osteosarcoma but also a thyroid gland carcinoma after a previous postsurgical mamma carcinoma whereby the irradiation dose of the radiation sarcoma is about 64 Gy and for the thyroid gland carcinoma about 12 Gy.

Adenoma↗
PubMed1990

Results of fast neutron therapy of adenoidcystic carcinomas of the head and neck at the neutron facility Hamburg-Eppendorf.

Between July 1977 and March 1988, 31 patients with an adenoidcystic carcinoma were treated with fast neutrons of a 14 MeV-DT-generator at our department. Primary locations were: parotid gland eight cases, paranasal sinus five cases, submandibular gland five cases, trachea four cases and other locations nine cases. The median follow-up of our patients was 16 months. Most of the patients had advanced tumors. The calculated local control rate is 65% at two years.

Adult↗
PubMed1990

Status report of fast neutron therapy in the Department of Radiotherapy at the University Hospital Hamburg-Eppendorf.

Since 1976 710 patients were treated with fast neutrons at the University Hospital Hamburg-Eppendorf. Since January 1984 154 patients with soft tissue sarcomas (250 patients with soft tissue sarcomas since 1976), 20 patients with advanced and low grade tumors of the paranasal sinuses and 43 patients with adenoid cystic carcinomas were treated with fast neutrons. Our results and reports from several centers indicate a gain from fast neutron therapy for low grade soft tissue sarcomas, osteosarcomas (G1 and G2), for highly differentiated salivary gland tumors, and some other rare low grade tumors as malignant chordomas, chondrosarcomas, pencil gliomas or desmoid tumors.

Adult↗
PubMed1990

Fast neutron radiotherapy for advanced malignant tumors of the paranasal sinuses.

The radiotherapy of advanced and low grade tumors of the internal nose and paranasal sinuses is still a problem. The results of neutron therapy of 20 patients with advanced and low grade tumors are presented. These patients were treated between July 1977 and October 1988. The mean age of patients is 53 years. Ten patients had adenoid cystic carcinomas, three patients squamous cell carcinomas, one patient a mucinous cell carcinoma, two patients a low grade adenocarcinoma and four patients low grade sarcomas. Mean follow-up is 16 months. Local control could be achieved in eleven cases. The results show that adenoid cystic carcinomas, low grade adenocarcinomas and sarcomas benefit from neutron therapy.

Adenocarcinoma↗
PubMed1990

[Life style and quality of life of children and adolescents following malignant tumor disease].

Psychosocial support after the diagnosis of childhood cancer is absolutely necessary to help not only the patients but also the parents, family members, and friends to deal effectively with the emotion and social problems arising from the disease. Psychological support for the whole family, rooming-in facilities on the ward, parent-self-help-groups, social and financial helps reduce problems which flow from such a diagnosis and may develop a positive coping strategy. Experiences over a long period of psychosocial aftercare in the University Hospital of Heidelberg are analyzed and some scientific data of this model are reported.

Adaptation, Psychological↗
PubMed1989

Functional and phenotypic analysis of tumor-infiltrating lymphocytes isolated from human primary and metastatic liver tumors and cultured in recombinant interleukin-2.

Tumor-infiltrating lymphocytes (TIL) were isolated from 40 of 51 consecutive human liver tumor samples (primary hepatocellular carcinoma, 16 of 18; metastatic, 23 of 29; benign, one of four). Functional and phenotypic characteristics of fresh and recombinant interleukin-2 (rIL-2)-expanded TIL were evaluated. The expansion of TIL from hepatic tumors in the presence of 1000 units/ml of rIL-2 was possible in 60% of cases. In comparison to TIL from metastatic liver tumors, TIL obtained from primary liver tumors expanded faster and better in rIL-2 cultures. Expanded TIL from primary tumors had significantly higher cytotoxicity against K562 targets, but not Raji targets, than those from metastatic tumors. Cytotoxicity against fresh autologous tumor targets was detected in seven of eight cultures tested. TIL from primary tumors retained antitumor reactivity significantly longer in culture. The optimal in vitro cytotoxicity was achieved between days 20 and 60 of culture in the presence of rIL-2. Antitumor activity was associated with the increase in these TIL cultures of a cell population expressing the Leu19 antigen with or without the CD3 antigen. The frequency of the CD3+Leu19+ population showed a bimodal distribution during culture: the first peak of CD3+Leu19+ cells occurred between days 30 and 60 and was associated with the increased antitumor activity; the second peak occurred after day 60 and was not associated with activity. These findings demonstrate that TIL from most human hepatic tumors can be successfully isolated, cultured in rIL-2, and enriched in Leu19+ effectors. In addition, these TIL upon IL-2 activation in vitro are capable of lysing fresh autologous and/or allogeneic tumor targets.

Antigens, Differentiation↗