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Biomedical subjects

R Schwartz

Publications and source records attributed to R Schwartz.

At least 469 records · Page 26Linked to original sources
PubMedDate not supplied

Effects of phytate reduction, fat extraction, and level of Ca on Ca and Zn bioavailability. Compared in vitro and in vivo.

The effect of phytate reduction, fat extraction, and addition of Ca in the form of skim or whole milk on Ca and Zn bioavailability from a breakfast containing bran muffins was studied in vitro and in vivo. Ca and Zn solubility were measured after in vitro simulated peptic and pancreatic digestion under pH conditions resembling those in the human GI tract. Absorption of Ca and Zn was measured in rats fed test meals tagged with 45Ca and 65Zn. Radioactivity in the femur and liver relative to levels found in rats injected with the isotopes served as criteria for 45Ca and 65Zn absorption, respectively. In vitro solubility was significantly depressed by the presence of phytate and inversely correlated with the phytate:Zn and the (phytate)(Ca):(Zn) ratios. Ca solubility was enhanced by extraction of fat and markedly increased by reduction in both fat and phytate. None of these effects was seen in vivo. However, 65Zn absorption was significantly decreased by fat extraction and phytate reduction although this treatment increased in vitro Zn solubility. Possible reasons for these discrepancies are discussed.

Animals↗
PubMedDate not supplied

Clonidine use and abuse among methadone program applicants and patients.

Forty-eight consecutive applicants and 30 known clonidine-abusing methadone patients at three methadone treatment programs were surveyed regarding their use of clonidine. Two distinct patterns of clonidine use emerged. Of 22 applicants who took clonidine illicitly, 15 used it primarily to decrease opioid withdrawal, as well as for its sedating effect. Applicants mostly obtained it from physicians, used an average dose of 0.37 mg at a time, and about one third believed clonidine to be addictive. In contrast, clonidine-using patients took clonidine primarily for its psychoactive effects, including the interaction with methadone, in addition to decreasing opioid withdrawal. Patients obtained clonidine frequently on the street and from family or friends, but less from physicians. The average reported dose for patients was 0.6 mg. The vast majority of these patients felt clonidine was addictive. Our findings, when coupled with the risk inherent in clonidine overdose, suggest that further research into the identification and treatment of clonidine abuse among methadone patients is warranted.

Adult↗
PubMedDate not supplied

Engaging hospitalized heroin-dependent patients into substance abuse treatment.

The purpose of this study was to evaluate a 6-month outpatient program developed to improve abstinence and other health and social problems of heroin-addicted persons hospitalized in an urban academic medical center's medical or surgical unit and referred from the Substance Abuse Consult Service. Treatment intervention consisted of methadone therapy, daily group therapy, individual case management, medical and psychiatric consultation, and social services. The first 67 patients referred were followed for 6 months. Outcome measures were retention in treatment, urine drug screens, and health and social indicators. Patients averaged 19 weeks in treatment, with 52% of patients completing the 6-month program. Urine toxicology screens showed a reduction of illicit drug use. Patients improved deficits in health and social indicators by obtaining medical coverage, keeping outpatient medical appointments, and improving their housing conditions. Findings suggest that this combination of intensive psychosocial treatment with opioid substitution following an acute illness substantially impacts treatment outcomes. Implications for service delivery and health-care economics are discussed.

Adolescent↗
PubMedDate not supplied

Evaluation of the Keystone Diagnostics Quik Test using previously screened urine specimens.

Urine specimens confirmed positive or negative for cocaine, phencyclidine, morphine, and amphetamines by thin-layer chromatography and gas chromatography/mass spectrometry were used in a blind study to evaluate the KDI Quik Test drug screen. Of 10 positive specimens, the KDI Quik Test found 6 to be positive, and of 10 negative specimens, it found 3 positive. In a study of interference, 4 of 10 specimens containing commonly used medications but no cocaine, phencyclidine, morphine, and amphetamine were found positive for the drugs of abuse by the KDI Quik Test.

Amphetamines↗
PubMedDate not supplied

Trimethoprim-sulfamethoxazole in the treatment of otitis media secondary to ampicillin-resistant strains of Haemophilus influenzae.

Between August 1977 and January 1979, 16 children (7 males and 9 females) ranging in age from 5 to 38 months (mean age 18 months) were treated with trimethoprim-sulfamethoxazole (TMP-SMX) (40 mg/kg SMX per 24 hours) for otitis media caused by beta-lactamase strains of ampicillin-resistant Haemophilus influenzae. Fourteen patients had failed after antecedent ten-day courses of ampicillin (9 patients) or amoxicillin (5 patients) therapy. The remaining two patients received only five days of ampicillin before changing to TMP-SMX. Six of the isolates were nontypable, 3 were type B, 5 isolates were Haemophilus parainfluenzae, and 2 strains were unavailable for typing. Of 13 strains tested, 10 had a minimal inhibitory concentration (MIC) in excess of 3.12 microgram/ml of ampicillin; the remaining 3 had an MIC of < 3.12 microgram/ml. All 13 isolates were susceptible to 0.19 microgram/ml TMP-SMX. Five of 16 children were symptomatic (irritable; fever of > 38.2 C); within three days of starting TMP-SMX treatment, they became asymptomatic. Fifteen of 16 patients (93%) responded favorably after ten days of TMP-SMX. Only one patient had H influenzae resistant to ampicillin (12.5 microgram/ml) and sensitive to TMP-SMX (0.19 microgram/ml) isolated from the middle ear at the end of ten days of TMP-SMX. At the end of TMP-SMX therapy, middle ear effusions were noted in ten patients; the fluid was sterile in the four patients who had a second tympanocentesis. There were two recurrences within one month of TMP-SMX therapy. No adverse clinical reactions were noted.

Ampicillin↗
PubMedDate not supplied

The athlete's mouthpiece.

This article points out several needs. The first is the need to have research on the design of the athlete's mouthpiece. This study demonstrates that the most frequently used athlete's mouthpieces alter the relationship of the lower jaw to the upper jaw. Second, this article expresses the need for design change in the present mouthpiece. It shows statistics that indicate a design change could be very advantageous to the athlete's performance. A strong case is made for viewing the mouthpiece as an aid as well as a protector.

Malocclusion↗
PubMedDate not supplied

The anatomy and histology of the inferior glenohumeral ligament complex of the shoulder.

The gross and histologic anatomy of the inferior glenohumeral ligament was studied in 11 fresh frozen cadaver shoulders. Arthroscopic observations of the joint capsule through the normal range of motion revealed that the inferior glenohumeral ligament is actually a complex of structures consisting of an anterior band, a posterior band, and an interposed axillary pouch. While these components of the inferior glenohumeral ligament complex were present in all 11 specimens, they were best demonstrated in some shoulders by placing the humeral head in internal or external rotation in varying degrees of abduction. Histologic examination of the joint capsule revealed that the anterior and posterior bands of the inferior glenohumeral ligament complex were readily identifiable as distinct structures comprised of thickened bands of well-organized collagen bundles. Although slight variations were noted in the attachment sites of the anterior and posterior bands to the glenoid, the inferior glenohumeral ligament complex was observed to attach to the humeral neck in one of two distinct configurations. A collar-like attachment, in which the entire inferior glenohumeral ligament complex attaches just inferior to the articular edge of the humeral head, was observed in six specimens. In the remaining five specimens, the attachment was in the shape of a "V," with the anterior and posterior bands attaching adjacent to the articular edge of the humeral head and the axillary pouch attaching at the apex of the "V" distal to the articular edge. The orientation and design of the inferior glenohumeral ligament complex supports the functional concept of this single structure as an important anterior and posterior stabilizer of the shoulder joint.

Arthroscopy↗
PubMedDate not supplied

Fetal macrosomia--animal models.

Macrosomia is characteristic of the infant whose mother has undiagnosed diabetes mellitus during pregnancy or whose diabetes has been inadequately controlled. Animal models of diabetes have included effects of pancreatectomy or beta-cell destruction by chemical agents. Maternal effects have been variable as have been effects on the fetus. Recent studies by Van Assche indicate that chemically induced diabetes may have genetically transmitted effects through three generations in rats. End-organ effects of hyperinsulinemia have been produced in normal fetal rhesus monkeys without maternal hyperglycemia. In this model, macrosomia and selective organomegaly similar to changes observed in the human infant of the diabetic mother were produced. Hepatic enzyme activities concerned with lipogenesis were increased, while some of those controlling gluconeogenesis were decreased. The primary effects of insulin in utero appear to accelerate growth.

Animals↗