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Biomedical subjects

R Schuster

Publications and source records attributed to R Schuster.

At least 145 records · Page 8Linked to original sources
PubMed1984

Hepatic artery embolization for treatment of endocrine gastrointestinal tumors with liver metastases.

We report about six patients with endocrine gastrointestinal tumors and liver metastases (four insulinomas, one carcinoidtumor, one paraganglioma), who were treated with a transluminal embolization of the hepatic artery when cytostatic therapy was ineffective. In two patients a second embolization was necessary after recurrence of clinical symptoms. All patients tolerated the procedure without severe side-effects and improved clinically. Serum insulin levels and HIAA-secretion rapidly decreased. Survival lasted from 3 to 32 months (median 15 months). Five additional patients with metastatic endocrine gastrointestinal tumors, observed during the same time period, were regarded as not suitable for hepatic artery embolization. In selected patients, hepatic artery embolization may become an effective therapy for treatment of metastasing endocrine gastrointestinal tumors when conventional medication with cytostatic drugs has become ineffective.

Adenoma, Islet Cell↗
PubMed1984

Diagnostic and Statistical Manual-III: a perspective from family court.

The third edition of the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-III) is evaluated from the standpoint of forensic science experience in a family court setting. The importance of diagnosis in developing pertinent recommendations within an adversarial system is discussed, with particular emphasis on difficulties in coordinating the Manual with the mental disorders frequently found in such a population. The limitations of the current criteria of the developmental disabilities are noted, and problems of reconciling incest and child abuse with the nomenclature are investigated. Some inconsistencies in the conceptualization of the conduct disorders and antisocial personality disorder are explored in terms of the needs of the juvenile justice system. An additional coding procedure is proposed for DSM-III, in order to identify more easily prodromal or emerging disorders of clinical significance.

Adolescent↗
PubMed1984

[Detection of the incidence of increased sensitization to molds in patients with bronchial asthma and allergic rhinitis].

The incidence of sensibilization against extracts of moulds produced by VEB SSW Dresden was investigated by intracutaneous tests in 354 persons (controls and patients - adults and children - with bronchial asthma and allergic rhinitis). Even in the nonallergic controls the tests were positive in 20-30%. Patients with asthma and rhinitis were significantly more often positive than controls with Mucor, Cladosporium and mixed-mould. There was no difference between the groups with Aspergillus and Penicillium. Testing with extract of mixed-mould is not effective. Positive results with the individual moulds were not excluded although the test with mixed-mould was negative. There was no essential difference in the incidence of sensibilization between adults and children with bronchial asthma using mould extracts of VEB SSW Dresden.

Adolescent↗
PubMed1984

[Intestinal injuries in rectosigmoidoscopy in expert opinion].

Based on criteria of evaluation in the field of rectoscopy, questions are derived which concern expert opinions on rectal lesions during rectoscopy. Excluding a dereliction, the authors take the view that, owing to the rare occurrence of rectal perforations in the course of an instrumental examination of the rectum, criteria can now be given in each case for applying the law on the extended material support of persons in the case of lesions due to surgical operations.

Expert Testimony↗
PubMed1983

[Significance of laboratory chemical parameters for the detection of metastases in breast cancer].

The diagnostic value of 7 laboratory parameters for the detection of metastases was investigated in 136 patients with verified breast carcinoma after mastectomy. The post-operative interval was 6 to 80 months (means = 27.5). 61 patients had multiple metastases as determined by physical examination, X-rays, computertomography, sonographic and scan procedures, while the other 75 patients had no evidence of metastases. Carcinoembryonic antigen (CEA), alkaline phosphatase (AP) and lactate dehydrogenase (LDH) proved to be reliable parameters for the presence of metastases; the combination of these 3 parameters had a sensitivity of 73.0% and a specificity of 94.7% in the detection of metastases. The additional determination of gamma-glutamyltranspeptidase (gamma-GT), blood sedimentation rate (BSR), C-reactive protein (CRP) and serum iron (Fe) increased the sensitivity of metastases detection to 83.8%, but the specificity decreased to 46.2%.

Adult↗
PubMed1983

Intra-arterial perfusion therapy with 5-fluorouracil in patients with metastatic colorectal carcinoma and intractable pelvic pain.

In a phase-II trial, 18 patients with intractable pelvic and perineal pain caused by local recurrent and/or metastatic colorectal carcinoma resistant to combinations of analgesics, systemic cytostatic chemotherapy and/or radiation were treated with intra-arterial perfusion therapy using 15-30 mg 5-FU/kg body wt./day for 1-5 days. Of 18 patients, ten achieved complete pain relief for 3-32 weeks (mean, 15.7 weeks); after the perfusion therapy eight used less than 50% of the amount of analgesics required before treatment; one patient had only a minor response; two patients were treated unsuccessfully. Side effects were mild and controllable. One patient died subsequent to arterial embolism in the leg where the catheter was placed; pelvic perfusion therefore appears risky in patients with severe arteriosclerosis.

Adult↗
PubMed1983

[Primary aspergillosis of the lung in leukoses].

The course, radiological features and pathological changes of primary aspergillosis in four patients with acute lymphatic leukaemia are described. Two patients died despite antimycotic therapy. Breakdown of the infiltrate could not be established radiologically, nor pathologically. In a further two patients, a 'primary aspergilloma' developed during the course of several days. Both patients survived. The radiological demonstration of a fungus ball and of an air crescent in a typical aspergilloma can be regarded as a good prognostic sign.

Adult↗
PubMed1983

[Reaction of the whole body to auxiliary liver transplantation].

Changes of hemoglobin, hematocrit, blood pressure, blood lactate concentration, and blood pyruvate concentration, as well as in the acid-base balance, the electrolyte metabolism, and the enzyme activities into the serum were investigated in auxiliary liver transplantation in 5 dogs. Transitory hypokalemia and hypoglycemia, a slight controllable acidosis caused by lactate accumulation, as well as a strong short-term increase of the enzyme activities in the serum are an expression of the functioning of the transplanted liver. Hyperkalemia, a massive increase of the blood lactate concentration with uncontrollable acidosis, a therapy-resistant depression in blood pressure, and a slow continuous increase of the enzyme activities in the serum are symptoms of the irreversible ischemic damage of the transplanted liver. The avoidance of an irreversible ischemic damage during the preservation, the maintenance of a normal blood pressure after the transplantation, as well as the compensation of acidosis, hypoglycemia, and hypokalemia are of decisive importance for a successful liver transplantation.

Acid-Base Equilibrium↗
PubMed1982

[Adenine nucleotides and metabolites of glycolysis in the liver in auxiliary transplantation].

The metabolic state of the liver during preservation as well as in and after auxiliary transplantation was investigated in dogs. The biopsy was carried out by means of TRU-CUT biopsy needle. - The ATP concentration, the storage of energy, the amount of the adenine nucleotides, and the ATP/ADP quotient decrease in the preserved liver. The AMP concentration, the concentration of the hexosemonophosphates and the mass-effective quotient of the phosphofructokinase increase simultaneously. The energy supply is the glycolysis exclusively. A lactate accumulation is avoided by continuous perfusion. - The changeover of the anaerobic to the aerobic energy preparation took place by degrees after the recovery of the liver circulation. The ATP concentration, the ATP/ADP quotient, the storage of energy, and the amount of the adenine nucleotides increase in the transplanted liver. - An irreversible ischemic damage of the liver appears in the metabolic state of the organ by a massive decrease of the ATP concentration below 0.7 mmol/kg, the amount of the adenine nucleotides below 1.8 mmol/kg, and AMP concentration.

Adenine Nucleotides↗