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Biomedical subjects

R Schuster

Publications and source records attributed to R Schuster.

At least 199 records · Page 11Linked to original sources
PubMed1975

[Sterno-costo-clavicular hyperostosis: a hitherto undescribed entity (author's transl)].

Persistent pulling pain in the sternum, clavicles and both first ribs, especially during cold and wet weather, necessitated medical investigations and treatment in 3 patients. Externally a cylindrical or spindle-shaped swelling of the clavicles was noticeable and two patients had signs of superior caval obstruction in addition. X-rays showed hyperostosis of the sternal and middle part of the clavicle, synostosis of the sternoclavicular joints with involvement of the two first ribs as well as a thickening and increase in breadth of the sternum. In one patient there were additional swellings of the first to fourth ribs bilaterally. During the period of observation there was no radiological progression of the bone disease. Apart from a consistently raised erythrocyte sedimentation rate blood chemistry was normal. The sterno-costo-clavicular hyperostosis led to bilateral occlusion of the subclavian veins with resulting upper venous congestion in two patients. Histology of the biopsy samples showed a characteristic hyperostotic spongiosclerosis in all three cases. The cause of this sterno-costo-clavicular hyperostosis is unknown. Clinical, radiological and histological findings indicate that it is a uniform disease which has not previously been described.

Biopsy↗
PubMed1973

Loss of isoantigens A, B and H in prostate.

Formalin-fixed tissues from 65 prostates were grouped and investigated by the technic of mixed cell agglutination reaction (MCAR) for studying isoantigens A, B and H. The results of this study indicated that the MCAR was strongly positive at the epithelium of the acini in the majority of patients with benign prostatic hyperplasia. On the other hand, patients with primary carcinomas and metastatic carcinomas of prostates were found to be uniformly negative for any agglutination reaction. Prostates from a group of younger individuals only showed a patchy distribution of the MCAR at the epithelium of the acini. In view of these findings, it seemed that the traces of isoantigens in normal prostates show a considerable increase when the disease process of BPH becomes manifest in this organ, while in cases of primary and metastatic carcinomas the isoantigens are totally lost. In the light of previous studies on similar lines, the various possible mechanisms for this sudden transition are discussed.

Adenocarcinoma↗
PubMed1973

Isoantigens A, B and H in benign and malignant lesions of breast.

Eighty-five specimens of breast tissue were grouped and investigated by the technic of mixed cell agglutination reation (MCAR) for studying isoantigens A, B and H (O). MCAR was found to be strongly positive at the epithelium of acini in all the 25 subjects with benign lesions (10 fibroadenomas, 10 cystic mastitis and 5 gynecomastias). On the other hand, all the subjects with diagnosis of primary carcinomas in breast (45 subjects) and their metastases (15 subjects) were found to be uniformly negative for any agglutination reaction. In view of these findings, it seemed that the isoantigens in primary and metastatic malignancies of breast are always lost, while in the benign lesions isoantigens are always present. Although the exact mechanism is not understood, it seems that, in malignancies with a glandular differentiation, some differences exist when these are compared to malignancies with a squamous differentiation. The various possibilities are discussed in the light of previous studies.

ABO Blood-Group System↗
PubMed1972

A comparative immunohistochemical study of splenic arterial hyalinosis in health and disease.

Hyaline deposits in arterioles and arteries of spleen were studied immunohistochemically. Hyaline lesions in arteriosclerotic heart disease were characterized by significant deposits of IgG, IgM, beta1C-beta 1A-globulins and beta-lipoproteins. These corresponded to histochemically stained deposits of acid mucopolysaccharides and microscopic areas of musculoelastic tissue damage in the hyaline masses. While, in young adults and a few other cases of other diseases, an occasional granular to linear deposit of IgG, IgM, beta1C-beta 1A-globulin and beta-lipoprotein was noted, no localization of IgA, rabbit antihuman fibrin and rabbit antihuman fibrinogen was seen. A variety of other histochemical staining reactions were found to be negative. These findings suggest that: a) hyaline deposits in splenic arterioles and arteries occur with greater severity in patients with hypertensive and arteriosclerotic heart disease; b) a possible abnormality related to filtration defects in arteries and arterioles, resulting in the trapping of plasma proteins, appears likely; c) increased localization of acid mucopolysaccharides and destruction of musculoelastic tissue is not an uncommon feature in hyaline masses; d) fibrin is not a component of these deposits and e) further study of other organs is necesary to observe the composition of hyaline in arterioles and arteries.

Adolescent↗