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Biomedical subjects

R Schindl

Publications and source records attributed to R Schindl.

At least 19 recordsLinked to original sources
PubMed1990

[Sleep apnea and the work site].

The sleep apnoea syndrome (SAS) is characterised by somatic, in particular cardiopulmonary and psychosocial, symptoms, the latter severely impairing the patient's social life. Excessive daytime somnolence and the resulting problems severely stress patients with SAS. Among 24 patients with SAS, 79.2% stated that they fell asleep during the day, frequently in 41.8% and occasionally in 37.4%. In addition, 70.8% of the patients with SA did not feel adequately rested on waking in the morning. Of the 24 patients, 17 had a job, and 11 of these experienced difficulty staying awake at the workplace. Suitable timely treatment (for example, with n-CPAP) improves not only the somatic, but also the neuropsychological symptoms.

Accidents, Occupational↗
PubMed1989

[Fibrosing lung process caused by TEL mineral wool].

The case of a 51-year-old man with pneumoconiosis caused by fibrous glass dust is reported. The diagnosis is confirmed by histological examination and by x-ray micro analysis using a scanning electron microscope. Pneumoconiosis following fibrous glass exposure should be taken into consideration in differential diagnosis of interstitial lung diseases.

Biopsy↗
PubMed1988

[Smoking and the respiratory tract].

Diseases of the airways increase and are of eminent social- and public health-care interest. As essential exogen noxious substance for cause in etiology is smoking considered. Incidence for bronchitis, emphysema, and lung cancer due to smoking is between 85 to 90%. Changes in the respiratory tract through smoking are also measureable function disturbances. They are more intensely than in dust-exposed nonsmoking workers. Also in passive smokers you can find such disturbances, the additional cancer risk is increased. Smoking is further one cause for centrilobular emphysema. Great international studies refer smoking as essential noxious substance for lung cancer. The minimal therapeutic success underlines the importance of early diagnosis, risk groups, significant etiologic factors, operability, chemo- and radiation-therapy. The early mortality for heavy smokers was ascertained up to 12.3 years lifetime-shortening. Overall the reason is adequate and serious enough to draw the attention to the effects of smoking to the respiratory tract besides tobacco-associated diseases of other organs with all emphasis and to make all efforts against this noxious substance.

Humans↗
PubMed1986

[Bronchitis and the environment--infrastructure].

Bronchitis in definition contains increased sputum production and cough. They gain importance through smoking and air-pollution. Both influences are good recordable. The last one is demonstrated by a regional air-monitor-net. Connections between air-pollution and airway diseases are seen in course-monitoring after pollution reducing actions. Essential complication of bronchitis as an airway disease in obstruction, airflow limitation. In small airways it runs at least synchronously. This obstruction is more sure and objective measureable than subjective complainted cough. This data, especially those of the flow-volume-loop, should have more weight. They correlate statistically significant in own studies in town-to-country differences to pollution, not to the only symptom of cough. Peak-Exspiratory-Flow and spirography show in comparison only a trend. The flow-rates might demonstrate more surely and objectively the environment-infrastructure in function data as possible cause for bronchitic airway diseases.

Air Pollution↗
PubMed1986

The effect of the cardioselective beta blocker celiprolol on pulmonary function in asthmatic patients.

The influence of single oral doses of 200 mg celiprolol, 100 mg atenolol, and 200 mg metoprolol on airway resistance (Raw) FEV1, VC, and MEF 50 was studied in a randomized double-blind crossover trial. Eighteen patients with hypertension and asthma, 14 men and 4 women, aged 43-75 years, took part. Pulmonary function tests were performed in the morning before treatment and 2 and 5 h after each treatment in the whole-body plethysmograph. The use of bronchodilators was not allowed during the 3 days. There was no significant change in airway resistance, FEV1, and MEF 50 after celiprolol and a slight increase of vital capacity at 2 h. After atenolol there was a decrease of FEV1 and MEF 50 at 5 h. Metoprolol caused an increase in resistance at 2 and 5 h and a fall in FEV1, VC, and MEF 50 at 2 and 5 h. Two patients required bronchodilator therapy after metoprolol and were excluded from evaluation. We conclude that celiprolol appears to be a safe drug in the treatment of asthmatic patients.

Adrenergic beta-Antagonists↗
PubMed1984

Augmentin in acute exacerbations of chronic bronchitis.

Forty-five patients with acute chronic bronchitis were treated with Augmentin, an amoxycillin combined with the beta-lactamase inhibitor clavulanic acid, initially by parenteral administration followed by oral treatment after 3 days lasting in the mean 7.1 days. The over-all clinical evaluation showed a cure rate of 93%. Side-effects were comparable to therapy with other amoxycillins. Bacteriological evaluation of the sputum samples demonstrated in 91% of cases an elimination of the initially isolated organism. Prior to therapy we found in 25% of the isolated strains beta-lactamase-producing and Augmentin-sensitive organisms. The parenteral formulation of Augmentin seems to be a valuable addition to the parenteral therapy of lower respiratory tract infections.

Acute Disease↗