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Biomedical subjects

R Saxena

Publications and source records attributed to R Saxena.

At least 253 records · Page 14Linked to original sources
PubMed1988

Non-surgical treatment of jejunogastric intussusception.

Three cases of retrograde jejunogastric intussusception who were managed endoscopically are described. The diagnosis was made by means of endoscopy in one case and contrast radiology of the stomach in the other two. Endoscopic management consisted of reduction of the intussusception, followed by placement of a feeding tube deep in the intussuscepting segment. The patients responded very well and surgery could be avoided in all of them.

Adult↗
PubMed1986

Histopathological changes induced in rat tissues by oral intake of lead acetate.

In the present study an attempt has been made to observe the pathological alterations brought about in the intestine, liver, and kidney of lead-intoxicated rats. A short-term exposure to a sublethal dose of lead (44 mg/kg body wt/day) is seen to cause conspicuous degenerative changes in the three tissues. The intestinal mucosal epithelium is affected which leads to malabsorption, while in the kidney proximal tubular cells degenerate causing secretion of essential materials such as glucose, amino acids, etc., in the urine.

Administration, Oral↗
PubMed1986

Effect of some anthelmintics on malate dehydrogenase activity and mortality in two avian nematodes Ascaridia galli and Heterakis gallinae.

Cambendazole and tiabendazole at 10(-4) M concentrations caused mortality in both the parasites after 10 min and 20 min, respectively. H. gallinae was killed by 10(-4) M haloxon but A. galli remained alive even after 60 min exposure. The effect of these drugs was found to be irreversible since no resumption of activity was observed when the parasites were returned to normal saline solution. The ratio of oxaloacetate reduction to malate oxidation in the homogenates of A. galli and H. gallinae was 4.38:1 and 3.17:1 respectively. Cambendazole at 10(-3) M inhibited the enzymic activity in both directions by 100% in both A. galli and H. gallinae. 10(-3) M tiabendazole, however, inhibited the malate oxidation by 82.8 and 60.8% and oxaloacetate reduction by 76.6 and 92% in A. galli and H. gallinae, respectively. Haloxon had little effect on malate dehydrogenase activity of any of the parasite. Assay of malate dehydrogenase, following the in vitro drug treatment cambendazole and tiabendazole, exhibited moderate inhibition of the activity in both the parasites.

Animals↗
PubMed1984

Cytogenetic effects of psychotropic drug haloperidol on human lymphocytes.

Haloperidol is used for long-term therapy of psychiatric disorders. The cytogenetic effect of this drug was studied on human chromosomes in lymphocyte cultures in vitro and in vivo. There was no increase in the chromosomal aberration frequency in vitro with haloperidol at concentrations equivalent to plasma level and slightly higher than plasma level. However, a significant increase in the frequency of chromosome aberrations was seen in patients on therapeutic doses of haloperidol as compared to the two types of controls: 1. Psychiatric patients before starting the drug therapy and 2. normal healthy individuals from the general population. The most frequently observed aberrations were chromatid gaps and breaks. Our study indicates that haloperidol is not clastogenic in vitro at plasma concentration but significantly clastogenic in vivo.

Adult↗
PubMed1982

Clastogenic effect of the psychotropic drug thioridazine on human chromosomes in vivo.

Thioridazine (Mellaril), a psychotropic drug belonging to the phenothiazine group of drugs, was evaluated for its in vivo clastogenic effect on human chromosomes in lymphocyte cultures. Lymphocyte cultures were set up with peripheral blood samples of psychiatric patients (diagnosis: schizophrenia, mania, manic depressive psychosis, acute psychotic episode) who were on therapeutic doses of thioridazine for over 4 weeks. Two sets of controls were used: (1) newly diagnosed psychiatric cases (same type as above) who were not yet under therapy and (2) healthy individuals from the general population. The chromosomal aberration frequency was found to be significantly increased in the patients exposed to this drug as compared to the two sets of controls. The results point to a clastogenic and mutagenic potential of thioridazine and warrent a more careful consideration of its use in medicine.

Adult↗
PubMed1981

The effect of five fasciolicides on malate dehydrogenase activity and mortality of Fasciola gigantica, Fasciolopsis buski and Paramphistomum explanatum.

The effect of oxyclozanide, hexachlorophene, nitroxynil, rafoxanide and diamphenethide on malate dehydrogenase activity of homogenates of Fasciola gigantica, Fasciolopsis buski and Paramphistomum explanatum was investigated. The ratio of oxaloacetate reduction to malate oxidation in homogenates of Fasciola gigantica, Fasciolopsis buski and P. explanatum was 4.5:1, 3.6:1 and 5.2:1 respectively. Oxyclozanide and rafoxanide at 10(-3) M inhibited enzyme activity by 100% in homogenates from all three species while hexachlorophene at 10(-3) M also caused 100% inhibition in homogenates from Fasciola gagantica and P. explanatum but only 65% of malate oxidation in Fasciolopsis buski homogenates. Nitroxynil at 10(-3) M produced 60% inhibition in F. buski homogenates yet had little effect at this concentration on preparations from the other species. Little inhibition was seen with diamphenethide, even at high concentrations. Rapid death of Fasicola gigantica and P. explanatum resulted in vitro when 10(-3) M oxyclozanide, hexachlorophene, nitroxynil or rafoxanide, were added to the incubation medium. Fasciolopsis buski was killed by 10(-3) M oxyclozanide but at this concentration the remaining compounds only caused reduced activity. Assay of malate dehydrogenase following drug treatment in vitro failed to show any appreciable reduction in enzyme activity in Fasciola gigantica and P. explanatum but oxyclozanide and hexachlorophene produced inhibition in Fasciolopsis buski. The mode of action of these compounds is discussed.

Animals↗