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R Sauter

Publications and source records attributed to R Sauter.

67 records · Page 4Linked to original sources
PubMedDate not supplied

31P-spectroscopy of head and neck tumors--surface coil technique.

Comparative phosphorus-31 magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) of 15 patients with superficial masses such as sarcoma, carcinoma, lymphoma, adenoma, and tuberculosis revealed significant increased concentrations of phosphomonoester, phosphodiester, and inorganic phosphorus in the lesion, whereas the concentration of the phosphocreatine was lower in comparison to muscle tissue. In nearly all masses, pH showed a slight alkaline shift. Existence of necrotic regions detected by MRI was marked by an increase of inorganic phosphorous in the spectra. Tumor growth was characterized by raised concentrations of phosphomonoester. Follow-up studies in a case of lymphoma showed a six-fold decrease of the tumor, while the spectra indicated a gradual transition of tumor values to muscle values. A follow-up study during irradiation of a squamous cell carcinoma revealed a considerable decrease of inorganic phosphate and a subsequent increase of phosphodiester.

Adult↗
PubMedDate not supplied

[Spinal sonography of a newborn infant with postpartal paraplegia].

Cranial ultrasonography is a well established diagnostic procedure. In contrast ultrasonography of the spine and the spinal cord is less frequently used. It is indicated in infants with spinal dysraphism and may help to diagnose patients with meningomyelocele, spinal lipoma or cord tethering. We present a newborn with parplectic symptoms as a result of an epidural hematoma, which could be demonstrated exclusively by ultrasonography. We want to stress that spinal ultrasonography is a method of high clinical value.

Cerebral Hemorrhage↗
PubMedDate not supplied

[A gait disorder caused by hereditary motor-sensory neuropathy].

Two sisters suffering from a hereditary motor-sensory neuropathy (HMSN) are described. A walking disturbance, deformations of foot, muscle atrophy, areflexia of the legs with disturbance of sensibility are detectable of them. Each of them, their motor nerve conduction velocity (NCV) of all extremities was slowed. The younger of the two sisters had graver symptoms and her sural nerve biopsy exhibited a reduced number of myelinated nerve fibres, some distinguished axon-calibre and onion bulb-formations. The relation of those findings to the classification of HMSN is demonstrated and the importance of NCV-measurement to clarification of walking disturbance is shown.

Axons↗
PubMedDate not supplied

[Severe hyponatremia as diagnostic symptom of cystic fibrosis].

Report on two babies, 5 and 6 months old with severe salt depletion were admitted to our hospital with fever and gastro-enteritis. One of them failed to thrive despite normal nutrition, the other one had a protracted gastro-enteritis. Both of them had a great loss of weight, a strong dehydration and were in reduced general condition but without any signs of coma or cerebral seizures. In the differential diagnosis cystic fibrosis with chronic loss of salt exacerbated during an infection, described as "Pseudo Bartter-Syndrome" was suspected. Both babies showed increased salt concentration in the sweat and decreased chymotrypsin in the stool.

Bartter Syndrome↗
PubMedDate not supplied

[Growing septum pellucidum cyst in infancy].

We report a baby's development with expanding cyst of the septum pellucidum. It was detected accidentally during diagnostic evaluation of epileptic convulsions and psychomotoric retardation. The dramatic increasing of the cyst was followed by cranial ultrasonography for ten months. The progression of clinical symptoms couldn't be explained because after drainage of the cyst, no improvement took place. MRT with Spectroscopy lead to the tentative diagnosis, Morbus Alexander. This couldn't be proved because no biopsy of the brain was performed against the decision of the child's mother, nor postmortal (the child died at 20 months).

Cysts↗
PubMedDate not supplied

The design and use of a dual-frequency surface coil providing proton images for improved localization in 31P spectroscopy of small lesions.

Nuclear magnetic resonance (NMR) spectroscopy of small lesions is restricted by the difficulties of localizing the surface coil with respect to the lesion and the problem of ensuring that signal is only obtained from the lesion and not from surrounding tissue. A double-tuned coil has been developed that permits NMR proton images to be obtained from a region of interest, prior to carrying out 31P spectroscopy of the same region with the same coil, without the need for further adjustment. The coil provides a means of accurately localizing the region from which the 31P signal is obtained, whilst offering a means of accurately applying 31P signal localization methods, and the possibility of making corrections for the nonuniform sensitivity of a given surface coil. The coil makes use of two parallel resonant circuits, with independent rf connections, but sharing a common coil. Simulated shorted and open circuit lambda /4 cables are used, respectively, to open circuit each circuit at the resonant frequency of the other circuit and ensure that the simulated lambda /4 line is short circuited for each circuit at the circuit's resonant frequency. At 63.6 MHz, the Q of the coil was 190 unloaded and 90 loaded, and at 25.7 MHz the Q was 210 unloaded and 140 loaded, for a 4-cm-diam coil. The coil has been used to obtain proton images and 31P spectra. A circuit employing only one input was also developed.

Humans↗
PubMedDate not supplied

Intratumoral lipids in 1H MRS in vivo in brain tumors: experience of the Siemens cooperative clinical trial.

Fifteen institutions cooperated to examine the ability of 1H MRS to characterize metabolism in vivo in 102 primary brain tumors. Spectra were acquired from single 8 cc voxels in the tumor using a spin-echo method with an echo time of 135 ms. The most intense lipid signal was that of fatty acyl methylene protons at 1.3 ppm. Intratumoral lipid signals were not detected in oligodendrogliomas, ependymomas, or meningiomas and were evident in only 1 of 6 primitive neuroectodermal tumors. Among 75 astrocytic tumors, lipid signals occurred in 16% of low grade astrocytomas (AS), 36% of anaplastic astrocytomas (AA), and 44% of glioblastomas (GB). The amount of lipids, expressed as a ratio of the intensity of the methylene signal to that of choline, increased progressively with histopathological grade (p = 0.05). Greater amounts of mobile lipids in vivo in GB, which usually contain necrosis, is in accord with the recently discovered correlation between the fraction of microscopic necrosis and the intensity of the mobile lipid signal observed ex vivo using 1H MRS. The observation of lipid signals in AA, which do not contain necrosis, suggests that mobile fatty acids may appear at a stage of metabolic insult that precedes microscopic signs of cell death, and raises the possibility of an independent correlation between 1H MRS-detectable lipids and prognosis in patients with astrocytic tumors.

Astrocytoma↗