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Biomedical subjects

R Sasaki

Publications and source records attributed to R Sasaki.

At least 253 records · Page 14Linked to original sources
PubMed1988

[A case of solitary metastasis of renal cell carcinoma to the thyroid gland].

A case of solitary metastasis of renal cell carcinoma to the thyroid gland is reported. A 63-year-old-woman had been found to have an abnormal mass in the neck since April, 1986. She had a past history of right nephrectomy owing to right renal tumor 6 months earlier. Histological examination of the renal tumor revealed, common type, alveolar type, G1, INF alpha renal cell carcinoma. No metastasis was found on abdominal CT, chest tomography and bone scintigram at that time. Radical thyroidectomy was performed on June, 23, 1986. Histological examination by hematoxylin and eosin staining revealed metastasis of renal cell carcinoma, and immunohistochemical technique ruled out primary thyroid carcinoma. Postoperatively no other metastasis was found on head-chest-abdomen-CT, chest-tomography or bone scintigram. Therefore no particular adjuvant therapy was performed.

Carcinoma, Renal Cell↗
PubMed1988

Malignant lymphomas and related conditions involving nasal cavity and paranasal sinuses: a clinicopathologic study of forty-two cases with emphasis on prognostic factors.

Lymphoproliferative diseases involving the nasal cavity and paranasal sinuses are uncommon and show complex histology, which make our understanding of the disease inadequate. In the present study, clinicopathologic findings, especially prognostic factors, in 42 patients with such diseases were reviewed. Histologically these cases were divided into ordinary lymphoma (23 cases) and a disease pattern that frequently showed a polymorphous picture containing large atypical cells with a non-lymphoid appearance (19 cases). The latter was termed midline malignant reticulosis (MMR) according to Kassel's classification. Clinically 'MMR' showed greater incidence of early onset of disease and higher male preponderance than ordinary lymphoma. The most common presenting symptom was nasal obstruction in both diseases. Favourable prognostic factors assessed by Cox's multivariate analysis were ordinary lymphoma (vs MMR), stage I disease, absence of ulceration in the lesions, and a tendency for local tumor formation.

Adult↗
PubMed1988

A notable change in mortality of aplastic anemia observed during the 1970s in Japan.

The age adjusted mortality rate of aplastic anemia in Japan decreased sharply in the mid-1970s; before this time, it had increased only slightly. A report on the survival rate among a substantial number of patients with aplastic anemia showed that patients who sought medical care at the hospital after 1973 had a better survival rate than those who sought care before 1973; the extent of improvement in the survival rate was almost equal to the extent of decrease in the mortality rate. The supply of platelet concentrates was found to increase with the decrease in the age adjusted mortality rate. Although there were several factors that affected the mortality rate from aplastic anemia, the major recognizable factor seemed to be therapeutic improvement, mainly due to the platelet concentrates. Probably neither a decrease in the incidence nor factors related to the data processing of vital statistics played a major role.

Adolescent↗
PubMed1987

Quantitation of serum carotenoid concentrations in healthy inhabitants by high-performance liquid chromatography.

Serum carotenoid concentrations in healthy subjects by age and sex were investigated, as determined by two high-performance liquid chromatography (HPLC) methods. Serum 'carotene' concentrations were 0.655 +/- 0.499 mumol/l 35.2 +/- 26.8 micrograms/dl) for 227 males, and 1,395 +/- 0.780 mumol/l (74.9 +/- 41.9 micrograms/dl) for 370 females. In addition, serum concentrations of alpha-carotene, beta-carotene, and lycopene were obtained from another sample included 356 males and 567 females living in the same area. alpha-Carotene for 356 males was 0.085 +/- 0.096 mumol/l (4.6 +/- 5.2 micrograms/dl), beta-carotene was 0.555 +/- 0.491 mumol/l (29.8 +/- 26.4 micrograms/dl), and lycopene was 0.372 +/- 0.273 mumol/l (20.0 +/- 14.7 micrograms/dl), respectively. Serum concentrations of alpha-carotene, beta-carotene as well as concentrations of lycopene in these inhabitants were significantly higher for females than for males (p less than 0.001).

Adult↗
PubMed1987

Characterization of erythropoietin receptor of murine erythroid cells.

Radioiodinated or biologically tritiated recombinant human erythropoietin was used to characterize receptors for this hormone on the surface of Friend erythroleukemic cells (745A and TSA8) and cells from mouse erythropoietic tissues (liver from fetus and spleen from animals made anemic by injection of Friend virus or phenylhydrazine). Specific binding of erythropoietin to these cells was time-dependent and dose-dependent. Binding studies at 37 degrees C showed that dissociation constants of erythropoietin-receptor complexes were in the range of 100-300 pM. The number of receptors on erythroleukemic cells increased after treatment with dimethylsulfoxide. Covalent binding of 125I-erythropoietin to its receptors with a cross-linking reagent, disuccinimidyl suberate or glutaraldehyde, resulted in the formation of two major radiolabeled products that migrated as 120-kDa and 140-kDa species on sodium dodecyl sulfate/polyacrylamide electrophoresis gels under reducing conditions. Under non-reducing conditions, both 120-kDa and 140-kDa species disappeared and two cross-linked products, a minor product with a molecular mass of 250 kDa and a major product of high molecular mass that kept it from migration into the separating gels, appeared. The relationship of the cross-linked products found under non-reducing conditions with those under reducing conditions remains to be clarified.

Animals↗
PubMed1987

A workplace-based case-control study of gastric ulcer among male municipal employees in Japan.

In order to detect risk factors of gastric ulcer among male workers in Japan, a workplace-based case-control study was conducted in a municipal government, using cases registered during 1981 to 1983 with individually matched controls. Statistically significant factors in univariate analysis were smoking, time interval from waking up to leaving home for job, meal time for supper, sleeping hours, anxiety, and gloomy feeling. Logistic analysis showed that among the above factors the significant relative risks were 11.9 (95% confidence interval: 1.6-89.4) for 1-9 cigarettes per day, 9.9 (2.6-37.7) for 10 cigarettes or more per day, and 5.3 (1.6-17.5) for gloomy feeling. These findings obtained among the male Japanese workers were almost consistent with those epidemiologic results in other developed countries that smoking and personality traits are major risk factors of gastric ulcer.

Adult↗
PubMed1987

The long-term prognosis of patients gastrectomized for benign gastroduodenal diseases.

To study the long-term prognosis after gastrectomy, a total of 6,662 gastrectomized patients who had been operated on for benign gastroduodenal diseases between 1965 and 1980 were followed up from September 1, 1984 to May 30, 1986. The final vital status for the observed period could not be confirmed in 493 patients (7.4%), giving a follow-up rate of 92.6%. The average observation period was 13.1 years. The mortality from total deaths was almost identical to that of the general population adjusted for sex, age, and time trends of mortality, except for lower mortality among males in the first five years after operation. The risk of cancer mortality at all sites was lower than that of the general population, mainly due to the lower mortality from stomach cancer. This trend was not affected either by the type of gastroduodenal disease or by the method of operation. However, lung cancer mortality among males was significantly higher and one of the reasons for that could be excess smoking by males.

Alcohol Drinking↗
PubMed1987

Smoking, alcohol drinking and serum carotenoids levels.

Serum carotenoids concentrations in healthy inhabitants, aged 40-79 years, of a community were measured. The results are as follows. 1. The alpha- and beta-carotene and lycopene levels in serum were significantly higher in females than males. The alpha- and beta-carotene concentrations tended to increase with advancing age, this being especially marked for serum beta-carotene levels in males. However, beta-carotene levels were high in females throughout the age range of 50-69 years. There was no significant change in serum level of lycopene with age. 2. There was no significant difference in intake frequency of foods containing large amounts of carotenoids among the groups with or without smoking and drinking, as serum alpha- and beta-carotene levels were closely associated with intake frequency of green-yellow vegetables. 3. Regular alcohol drinkers or current smokers showed lower serum beta-carotene concentrations, and the effect of alcohol drinking on serum carotene level seemed to be larger than that of smoking. A synergistic lowering action of smoking and drinking on serum beta-carotene level was suggested. Among the alcohol drinkers, the more cigarettes consumed per day, the lower the serum beta-carotene level was, but this was not the case among the non-drinkers. Ex-smokers showed intermediate values between current smokers and non-smokers. The results suggest that alcohol drinking and smoking habit might be associated with lower serum beta-carotene level, which in turn may be related to excess incidence of cancer among smokers or drinkers.

Adult↗