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Biomedical subjects

R Santini

Publications and source records attributed to R Santini.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Glycosylated extracellular domains of membrane immunoglobulin M contribute to its association with mb-1/B29 gene products and the B cell receptor complex.

It has recently become clear that the B cell antigen receptor, membrane immunoglobulin (mIg) is part of a complex composed of a number of different polypeptides. In a manner analogous to the T cell receptor, mIg has been found to be associated with several tyrosine kinases, and other proteins, which although not kinases themselves become targets of kinase activity upon binding of mIg to antigen. Thus the B cell receptor complex appears to be a structure whose function during signal transduction is to facilitate the interaction of tyrosine kinases with their proper substrates, and to coordinate the phosphorylation of these proteins with the binding of antigen to mIg. In an effort to understand the nature of the interactions which mediate the organization of the B cell receptor complex, we have explored binding of components of the complex including Ig-alpha and Ig-beta to IgM. Previous results have indicated that binding was mediated by transmembrane domains. Our results indicate that extracellular domains of IgM may also contribute to its association with Ig alpha and beta and other members of the B cell receptor complex.

Amino Acid Sequence↗
PubMedDate not supplied

[Electrical activity of the intestine in the conscious dog. Simultaneous pharmacologic investigation by chronic electrodes and electroperitoneography (author's transl)].

Two technics (chronic electrodes-electrointraperitoneography : EIG) have been used simultaneously in the conscious dog for the pharmacological study of drug effects on the electrical activity of intestine. The results show a good correlation between records obtained with the technic which needs a surgical operation (chronic electrodes) and the other which doesn't (EIG). The expected effects of the parasympathomimetic (acetylcholine-neostigmine) parasympatholytic (scopolamine) and adrenergic (epinephrine-neosynephrine) drugs used on the spiking activity are obtained with the two technics.

Action Potentials↗