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Biomedical subjects

R Sands

Publications and source records attributed to R Sands.

15 recordsLinked to original sources
PubMed2002

Low dose 25 mg oestradiol implants and 1 mg norethisterone as continuous combined hormone therapy: a prospective study.

The anxiety regarding no-bleed regimens is that breakthrough bleeding and endometrial hyperplasia may occur. We aimed to demonstrate that 25 mg oestradiol implants can be adequately opposed by a low dose of progestogen protecting against osteoporosis. Twenty-two patients were recruited to the study. The mean age was 62 years and body mass index of 26.5. Median oestradiol rose from 77 pmol/L at baseline to 275 pmol/L at one year. Median endometrial thickness remained unchanged at 4 mm and only two women withdrew with bleeding problems. There was one case of proliferative endometrium at one year--all others samples were either atrophic or secretory. Lumbar bone density (L2-L4) rose significantly from 0.939 to 0.992 g/cm2 (6%, P = 0.005) and the total femoral density rose from 0.872 to 0.890 g/cm2 (+2.1%). Bone formation markers increased significantly (serum type 1 procollagen C terminal peptide, P1CP = 112-114, P = 0.0376) and bone resorption fell (serum type 1 collagen C terminal telopeptide, 1CTP = 3.0-2.9, P = 0.2863). E25 implants and low dose progestogen appear to avoid endometrial hyperplasia and bleeding problems while increasing bone density.

Absorptiometry, Photon↗
PubMed2000

Reconceptualization of body image and drive for thinness.

OBJECTIVE: This study examined the nature of body image and drive for thinness as multidimensional constructs. Subjects included 111 early adolescent (ages 11-13) girls in Grades 7 and 8 from a private school in Melbourne. METHOD: The participants completed a suite of perceptual, affective/attitudinal, and behavioral measures that included assessment of body mass index, self-concept, body parts, silhouette discrepancy, self-worth, multidimensional body image, body image dissatisfaction, social physique anxiety, eating attitudes and behaviors, and physical activity. RESULTS: The sample reported moderate levels of body image dissatisfaction and a significant association of body image dissatisfaction with drive for thinness. Findings verified the important contribution of the affective/attitudinal components of body image. DISCUSSION: A multidimensional scale devised to test the value of a combined index of self-perceived size, shape, weight, tone, and appearance proved the most effective predictor among the alternative affective/attitudinal scales of body image dissatisfaction. Drive for thinness, as central to this study, was found to be related to, yet distinct from, body image on the basis of behavioral elements such as dieting and activity levels. These findings have ramifications for the design of future research in the body image, drive for thinness, and disordered eating domains. 2000 by John Wiley & Sons, Inc.

Adolescent↗
PubMed2000

Responding to a natural disaster with service learning.

This article describes a service learning experience at the University of North Carolina School of Medicine. Responding to a nearby natural disaster, the curriculum was modified to allow 71 second-year medical students to provide needed aid to affected communities and also fulfill learning objectives important to their training. The description and the lessons learned provide an example of how service learning experiences can be implemented to enrich a curriculum.

Adult↗
PubMed1997

Disordered eating patterns, body image, self-esteem, and physical activity in preadolescent school children.

OBJECTIVE: Eating disorders have been typically defined as an "adolescent problem." As a result of emerging evidence which indicated this health problem to be evident in the prepubescent age range, this study aimed to establish prevalence and factors associated with eating/dieting, physical activity, and body image among a nonclinical, naturalistically-derived sample of preadolescent (aged 10 and 11) school children (n = 61). METHOD: This cohort of children, which represented the entire grade 6 class of a suburban Elementary school, was measured for body image satisfaction [silhouettes], a participation in activity index, a self-worth scale and a measure of eating attitudes & behavior [Eating and Me scale [E & M]]. RESULTS: The longitudinal assessment of body image [3 measures over 9 months] indicated signs of stability of "actual" assessments of body image for males, but marked changes for females who preferred to be ideally "chunkier" in stature over time. Physical activity was only implicated with bulimia for the male sub-group. The E & M scale reported a Cronbach's alpha of .76, with two factors [bulimia; drive for thinness/anorexia] representing 65% of the total variance. Moderate internal validity [r .58] between body dissatisfaction on the E & M scale and the silhouette measure was observed. DISCUSSION: These results demonstrated that body image views and concerns appeared before puberty, that gender differences prevailed with respect to eating/dieting, activity and body image, and that the E & M scale has emerged as a promising research tool. The longitudinal nature of this study of eating disorders also promotes the need for qualitative research methodology and attention to pre-pubertal cognitive/perceptual processes.

Anorexia↗
PubMed1996

Hormone replacement therapy for women after breast carcinoma.

The use of hormone replacement therapy after the diagnosis of breast cancer has been contra-indicated because of the fear of precipitating a relapse. However, many survivors of breast cancer experience debilitating symptoms as a consequence of oestrogen deficiency and over the long term are at an increased risk of dying prematurely from cardiovascular disease or a hip fractures because they are denied hormone replacement therapy. The past year saw definitive reviews on this subject as well as publication of the largest case-controlled study of hormone therapy in women with a history of breast cancer. The encouraging findings of these non-randomized studies have prompted the commencement of prospective studies to evaluate the benefits and risks of this practice. It is no longer contra-indicated to prescribe hormone replacement therapy to selected women after a history of breast cancer but it remains controversial and more information is required.

Breast Neoplasms↗
PubMed1995

Exogenous androgens in postmenopausal women.

There is an increasing awareness that androgens are of therapeutic value in postmenopausal women. Evidence is emerging demonstrating the role of testosterone in both female embryologic development and normal sexual behavior and mood. Women who are androgen depleted develop physical and behavioral symptoms referred to as female androgen deficiency syndrome. To a lesser degree, women who undergo an oophorectomy are deprived of endogenous ovarian androgens and have consistently been shown to have impairment of sexual functioning, loss of energy, depression, and headaches. Testosterone seems to act synergistically with estrogen in the treatment of these symptoms. The combination of estradiol and testosterone has been shown to have a beneficial effect on the skeleton, although not significantly better than estradiol therapy alone. Cosmetic side effects are rare if supraphysiologic doses are avoided. The potential metabolic complications have not been consistently demonstrated in studies to date. Androgen replacement therapy is a neglected area of medical practice and further research is needed to identify all women who will benefit from it since studies in menopausal women have shown parenteral administration to be well tolerated and safe. Such therapy is underused and very much underresearched. While testosterone implants work adequately, it would be more desirable and convenient to use a testosterone patch and safer, more effective oral androgens, if these products were available.

Androgens↗
PubMed1992

Effects of compaction and simulated root channels in the subsoil on root development, water uptake and growth of radiata pine.

Effects of subsoil compaction and simulated root channels (perforations) through the compacted layer on root growth, water uptake, foliar nutrient concentration and growth of radiata pine (Pinus radiata D. Don) were studied in a field experiment where a range of treatments were applied in reconstituted soil profiles. Subsoil compaction adversely affected root penetration in deeper parts of the soil and consequently caused greater water stress in trees. However, the effect of compaction was largely overcome when the subsoil was perforated to render 0.2% of the soil volume into vertical channels. Roots showed a remarkable ability to reach the points of low penetration strength and to travel through them to deeper parts of the profile. Perforations through compacted soil layers at a relatively low frequency may be a practical solution to allow root development into deeper parts of the soil and allow greater soil water exploration by roots.

Journal Article↗
PubMed1992

Diurnal variation in extension growth of leaves of Salix viminalis.

Diurnal variation in leaf extension and biophysical parameters of leaf growth were measured in young leaves from a stand of Salix viminalis L. in southern Sweden over a two-day period of clear skies during late July. Leaf growth rate (irreversible extension) was greatest during the late afternoon and early evening, falling to negligible values during the night and early morning.Leaf water potential and leaf osmotic potential showed declining values in the morning with subsequent recovery in the late afternoon. Diurnal variation in osmotic potential (-1.3 to -1.7 MPa) was small compared with that of leaf water potential (-0.1 to -1.2 MPa). Calculated values of leaf turgor pressure during the night (1.2 MPa) were double the midday values. Growth rate correlated poorly with turgor, which (except on one occasion) was always above a calculated value of yield turgor at 0.53 MPa.Diurnal variation in extension growth rate was large compared with that in plastic extensibility of leaf tissue as measured by an Instron technique. Values of extensibility were low and showed little diurnal variation, which is consistent with a proposed negative feedback of expansive growth rate on extensibility. Extension growth rate correlated well with air temperature, suggesting that the rate of leaf expansion may have been limited by a temperature-dependent rate of cell wall loosening.

Journal Article↗
PubMed1992

Soil water content, soil strength and the growth of elm root suckers.

The elongation rate of root suckers of Dutch elm (Ulmus x hollandica Mill.) increased with increasing age of the sucker, soil water content and net growth pressure (the excess of turgor pressure over soil restraining pressure) and it decreased with increasing soil strength. The increase in the rate of sucker elongation with age was probably the result of a decrease in osmotic potential causing an increase in the turgor pressure. Increasing soil strength increased the rate of osmotic adjustment. The increase in the rate of sucker elongation with increasing soil water content was probably due to an increase in the water potential of the sucker and a decrease in soil strength associated with increasing soil water content.

Journal Article↗
PubMed1992

A leaf phosphorus assay for seedlings of Acacia mangium.

Concentrations of extractable and total phosphorus in leaves, stem, root and nodules of 12-week-old seedlings of two provenances of Acacia mangium Willd. were analyzed to identify the fraction of phosphorus and the plant part most suitable for predicting the phosphorus nutritional status of the seedlings.For both provenances, concentrations of extractable phosphorus were more sensitive to changes in soil phosphorus status and varied less among different plant parts than concentrations of total phosphorus. Concentrations of extractable phosphorus in the youngest fully expanded leaf (Leaf 3 from the apex) and the next two older leaves correlated closely with seedling dry mass and may be used to assess the phosphorus nutritional status of Acacia mangium seedlings.

Journal Article↗
PubMed1978

Effects of marijuana extract distillate and cannabidiol on variable interval performance as a function of food deprivation.

Lever-pressing rates plotted as a function of number of hours of food deprivation produces an inverted U curve, the activation performance curve. Since delta 9-tetrahydrocannabinol depresses the response rate on variable interval (VI) performance, it may be that the response depression reflects changes in this curve. Rats were tested VI performance at five levels of food deprivation and were treated with a vehicle control, marijuana extract distillate (MED) at 7.5 and 11.25 mg/kg, cannabidiol (CBD), at 15 mg/kg or combinations: 7.5 mg/kg MED + 15 mg/kg CBD and 11.25 mg/kg MED + 15 mg/kg CBD. MED produced a depression of VI performance which was greatest at low levels of deprivation. CBD did not depress performance. When CBD was conbined with MED, potentiation of depression occurred. The potentiation depression was not additive, but occurred at high levels of deprivation. It appears that MED depresses performance most at low levels of deprivation and that CBD potentiates the depression produced by MED at high levels of deprivation.

Animals↗
PubMed1976

Henbane chewing.

A case is presented of deliberate chewing of the flowers of henbane (Hyoscyamus niger) in the hope of producing euphoria, and an account is given of the poisoning so produced. The case indicates a more widespread use of this plant among the drug-taking community of Australia, and discussion of the case includes a description of the plant and an outline of treatment for the acute stage of the poisoning.

Adult↗
PubMedDate not supplied

Evaluation of peripheral morphine analgesia for lumpectomy and axillary node dissection: a randomized, double-blind, placebo-controlled study.

BACKGROUND AND OBJECTIVES: Morphine may elicit potent antinociceptive effects by binding and activating peripheral opioid receptors. However, the results in clinical studies have varied. We examined the postoperative analgesic effects of incisional morphine in patients undergoing lumpectomies and axillary node dissections for breast cancer. For this purpose, a concentration of morphine within the range (0.25-0.6%) of those utilized in previous studies for postarthroscopy analgesia was chosen (0.6%). METHODS: Forty-five patients scheduled to undergo a lumpectomy and axillary node dissections for breast cancer were enrolled in this study after receiving Ethics Committee approval and patient consent. Patients were randomized to undergo irrigation of the surgical sites for 5 minutes prior to skin closure with 6 mg morphine diluted in 100 mL 0.9% normal saline (NS) and placebo intramuscular (i.m.) (peripheral MS group), 100 mL of 0.9% NS alone and placebo i.m. (placebo group), or 100 mL of 0.9% NS and 6 mg morphine i.m. in the deltoid muscle (i.m. MS group) in a double-blind fashion. In the postanesthesia care unit, patients received fentanyl via a patient-controlled analgesia (PCA) device programmed to deliver 25 microg every 10 minutes to a maximum dose of 150 microg/h. Patients were evaluated for pain using a visual analog scale card from 0-10, opioid consumption, and incidences of side effects at 2, 6, 12, 18, and 24 hours after surgery. RESULTS: All patients had adequate analgesia at rest and during arm movement with visual analog pain scores (VAPS) <3/10 throughout the study period. There were no significant differences in demographics, total fentanyl consumption (500 vs. 475 vs 933 microg, respectively; P = .2), VAPS at rest and during arm movement as well as fentanyl consumption at the different evaluation points among the three groups. CONCLUSIONS: These results suggest that under the conditions of the study protocol, there is no value in utilizing morphine in solution at the surgical site for postoperative lumpectomy and axillary node dissection analgesia.

Analgesia↗