Biomedical subjects
Publications and source records attributed to R Samlali.
The authors present results that were obtained by combining endoscopic resection and external beam radiation therapy in a population of 55 patients presenting with bladder cancer. They also explain the difficulties they encountered in the management of bladder cancer at the Ibn Rochd Cancer Center (Casablanca, Morocco).
A retrospective study of 337 cases of cervix cancers in women aged 35 years and under, treated between 1980-1990 at the Ibn Rochd Oncology Center in Casablanca, was analyzed in order to determine the main characteristics of this disease and the influence of age on prognosis. The incidence of these cases was stable throughout the 11 years study period with a mean of 7.4% of all cervix cancers. The rate of early sexual activity in age under 18 years was particularly high, with 80%, of which 45.4% before the puberty. The advanced cases were predominating (58.2%). Earlier cases were treated with combined radiotherapy and surgery and advanced cases with radiotherapy alone. Overall survival rate was 41% at 5 years. It was 45.2% for the 31-35 years of age group and 32% for women aged 30 years and less. The prognosis of these younger women was especially poor in tumoral volume more than 3 cm, in advanced cases, in undifferentiated carcinoma and in cases of lymph node involvement. The comparative analysis of all prognostic factors in function of the age had permitted to show that women aged 31-35 years old have been a good prognosis, concerning survival at 5 years, in regard to women less 30 years.
This study is an analysis of the induction chemotherapy contribution in non metastatic nasopharyngeal carcinoma. Three chemotherapy cycles ("modified BEC" or not BEC, BEC: bleomycin-épirubicin-cisplatinum,) were delivered before irradiation in 90 patients. The rate of objective response was 57%. The chemotherapy response was better in patients no more than 35 year age, presenting with UCNT and not T4 or N3. Meanwhile, the chemotherapy protocol did not influence the response. The irradiation allowed the sterilization of 51 tumours and 49 of which were in satisfying response after chemotherapy. The sterilization by radiotherapy was influenced by the same factors as chemotherapy. The evolution showed 7 locoregional recurrences, 7 metastatic recurrences, and 2 patients presented with locoregional and metastatic recurrences. According to the Kaplan and Meier method, survival at 36 months was 61%. It was influenced by the same factors as chemotherapy and radiotherapy responses. The determining factor was indeed the chemotherapy response.
Leiomyosarcoma of the larynx is extremely rare, only 21 cases were reported in the literature. The authors report a personal case in a 26 years old patient treated by a total laryngectomy and analyse all cases of the literature. It comes in relative young man (42 years old) in regard to the others ORL localisations. There is not tobacco relation. The lymph node extension is rare however the distant metastasis are frequent specially in lung. The treatment is based on surgery, the neck lymphadenectomy is possible in patients with cervical lymph nodes. The Leiomyosarcoma is a resistant tumor to the irradiation and chemotherapy however the postoperative irradiation is justified. The prognosis of this tumor is reserved on account of local recurrences and distant metastasis.
From 1980 to 1990, 50 children were treated for nasopharyngeal carcinoma in the Department of Oncology at the hospital Center Ibn Rochd in Casablanca. There were 34 boys and 16 girls with a median age of 12.3. UCNT were observed in 70% of cases. Fourty six percent were stage T3-T4 and 70% were N2-N3 disease. All children received irradiation therapy and 16 of them have had a neo-adjuvant chemotherapy. Thirty seven children were evaluable, the immediate response was complete in 26/37 cases. Recurrence of disease was noted for four children and metastatic for four others children. Two children have both recurrence and metastatic disease. The overall survival was 40.5% at 3 years. Disease free survival was 37.8% at 3 years.
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A prospective investigation about the influence of the tabagism and its characters on the laryngeal cancer has been led in the department of oncology in the Hospital Center Ibnou Rochd in Casablanca from December 1990 to June 1991. The investigation concerned 58 new patients. We conclude from this investigation that the risk of cancer increases with the intensity of the tabagism (the precocious age at the beginning, long duration, high number of packets/years; black tobacco, deep inhalation of the smoke, absence of weanling). The risk increases with the association with an intense alcoholism. We don't find the professional exposition. These cancers related to tobacco have epidermoid predominance. Finally, the major interest of this study is to convince us about the ampleness of this flail and to lead us through an educative action for the preventive fight against tobacco because of the risk of laryngeal cancer.
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Liposarcoma of the larynx is an uncommon tumor. Only 27 cases have been described in literature. We report a new case occurring in a 50-year-old patient. The treatment consisted of a total laryngectomy with lymph node dissection followed by adjuvant irradiation. Prognosis for laryngeal liposarcoma is better than that of non laryngeal liposarcoma. This tumor is at high risk of local recurrence and seldom has metastatic potential.