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Biomedical subjects

R Sambuc

Publications and source records attributed to R Sambuc.

49 records · Page 3Linked to original sources
PubMed1982

[A new thyrotoxicosis index (bases for calculation and applications)].

A new thyrotoxicosis index (pointer) is calculated according to frequency of signs and symptoms in a well documented population of 189 thyrotoxicosis and pseudo thyrotoxicosis cross matined patients. Applied to a computerized population of 3 596 thyroid complained patients, this index provides four groups. Index greater than or equal to 8,5 : thyrotoxicosis is quite sure (92.5%), 8,5 less than or equal to index less than or equal to 5 : 3 of 5 patients are thyrotoxicosic 5 less than index less than - 1:1 of 5 patients is thyrotoxicosic (rough thyrotoxicosis), index less than or equal to - 1 : thyrotoxicosis can be refuded (98%).

Graves Disease↗
PubMed1980

Prolonged electrical systole in acute myocardial infarction.

Electrical systole duration has been studied in two groups of 23 patients (39 M and 7 F) admitted in the coronary care units of two different hospitals for documented acute myocardial infarction (AMI). The mean QT interval duration corrected for heart rate (QTc) was obtained from three measurements of non consecutive complexes in five different leads and compared to the ideal electrical systole duration of a normal population with the same cardiac cycle length. During the evolution of AMI, QT interval increased in both groups of patients (11.5% and 14.8% respectively) and was prolonged (17.6% and 21.5% respectively) at the 48th hour. Prolongation of electrical systole can be best measured using the ratio: QTc (according to Bazett)/normal QT (according to Ashman).

Electrocardiography↗
PubMed1980

[Surgery of tetralogy of Fallot in the first year of life (author's transl)].

Despite the very good results published by B. Barrat Boyes and A. castaneda with early correction of Tetralogy of Fallot in the first year of life, the authors prefer palliative surgery for this group. They have operated upon 47 infants less than one year of age, 15 of them being less than 2 weeks of age. The overall mortality is 4%, the only two deaths being in the neonate group, which is usually a very small group in the published series with early correction. Since all the children with S.P. Shunt performed for Tetralogy of Fallot can wait 2 to 4 years before complete correction, and since the mortality of corrective surgery at 4 years of age is almost nil, the authors think that the two stages approach give as good results than one stage surgery, despite the possibility of neurological complications which may occur between operations. They argue that with early correction, surgeons are obliged to put more transannular patches which result in more pulmonary insufficiency cases, and that the mortality in this age group is still very high in some publications. They have also compared the percentage of low cardiac output syndrome after correction and found that children with a previous S-P shunt have smoother post-operative course. Finally they think that it is possible to obtain a global mortality around 7% for the 2 stages approach and that this kind of surgery is technically easier than early correction and must be very useful for the majority of cardiac centers interested in congenital heart disease.

Age Factors↗
PubMedDate not supplied

[Correlative study of E.E.G. and C.T. scan data during normal and pathological cerebral aging (author's transl)].

A total of 109 subjects aged 60 years or more and without any focalized cerebral lesions were studied by E.E.G. and C.T. scan recordings. An original type of planimetric study of the C.T. scan sections was used to obtain numerical ratios of the degree of cerebral atrophy. The planimetric ratios and the E.E.G. data were then studied as a function of age-group and clinical condition. Most of the data obtained was then treated in a computer. Ventricular dilatation is a constant and progressive feature of normal aging, and is therefore correlated with its, whereas it cannot be significantly correlated with senility changes. The E.E.G. shows no precise correlation with age during normal aging but reflects the functional disturbances of senility disorders, especially dementias. There is no correlation between the E.E.G. and C.T. scan results either during normal or pathological aging.

Aged↗
PubMedDate not supplied

[New blood transfusion partners in France].

The French Blood Agency, created in 1993, controls all aspects of the blood transfusion system. It is responsible for restructuring the blood transfusion system and for Good Manufacturing Practices. All incidences are reported to the blood monitoring system which also obtains further descriptions of such incidents. Blood transfusion policies have been modified to include monitoring of blood-associated morbidity. Successive reforms have led to the establishment of a new public system for blood transfusion. New structures and more formal designation of responsibilities are needed. The function of these new structures is to better control transfusion activities and prevent unknown risk.

Blood Banks↗
PubMedDate not supplied

[Reaction surveillance: organization in public care/hospitals in Marseille].

For the French Drug Agency (AFSSAPS), the aim of the reactovigilance is to monitor the adverse effects resulting from the use of IVD-MD. More precisely, the goal is to evaluate all incidents and risks that can result in inadequate results or negative effects to the user and therefore for the patient. According to the French Law and before the transposition in the French Law of the European Guideline 98/79/CE, the University Hospital of Marseille has decided to organize its own reactovigilance network. Since 2001, an institutional organization has been set up. For each of the 33 labs of the University hospital one reactovigilant has been nominated as well as one coordinating reactovigilant. Specialized structures have been created: one central committee and one experts group. Standardized operating procedures have been established. The reactovigilance system is also integrated to the vigilance coordination network of the Marseille University Hospital. This organization allows to achieve tracability of all alerts, as well as information and training for the professionals. Four missions are defined: collection and management of all incidents IVD-MD-related; diffusion of AFFSAPS and industrials alerts to all labs in order to take appropriate measures; Tracability of alerts and incidents in all labs and in central committee, tracability of reactives according to French guidelines (GBEA). For the first 10 months of 2002, 46 alerts have been forwarded to all lab's correspondants. In the same period, one real adverse event has been locally notified and after analyse will be forwarded to the AFSSAPS. All these factors should contribute to the health professionals interest and participation in reactovigilance activities.

Consumer Product Safety↗