[Surgical management of recurrent carcinoid tumor of the thymus].
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Adult↗
Biomedical subjects
R Saitoh
Publications and source records attributed to R Saitoh.
A simple histochemical screening method for amine uptake.
A simple histochemical method for screening amine uptake in vitro is described. The filum terminale and the Vibratome sections of the caudate nucleus of reserpinized rats were used as the sources of noradrenaline (NA) and 5-hydroxytryptamine (5-HT), and as the sources of dopamine (DA) containing neurons, respectively. When incubated in an oxygenated medium (Krebs-Ringer) containing the corresponding amines, these preparations effectively accumulated the amines. 6-Hydroxytryptamine (6-HT) was used instead of 5-HT because of its stronger fluorescence and lower photo-decomposition of beta-carboline formed from 6-HT. The inhibitory patterns of representative uptake inhibitors obtained by the present method agreed well with those reported previously by biochemical methods. Effects of other types of drugs were also studied. The present method is a simple, rapid and non-radioisotopic method for determining amine uptake inhibiting action of a drug and the degree and selectivity in which it acts on the three kinds of amines.
Animals↗
The value of dynamic MR imaging for hypointensity lesions of the peripheral zone of the prostate.
The aim was to evaluate the role of dynamic magnetic resonance (MR) imaging for prostatic carcinoma. Forty-two men with clinical suspicion of a prostatic carcinoma underwent MR imaging. Dynamic MR was performed, followed by postcontrast T1-weighted imaging with fat suppression. Histologic diagnosis was 21 prostatic carcinomas (in 19 patients), 21 benign tissues, and 2 chronic prostatitis. The diagnostic accuracy was 75% for T2-weighted images, and 79% for dynamic images. The accuracy of the combination of dynamic MR images with postcontrast T1-weighted images was 82%. It was concluded that dynamic MR imaging was useful in differentiation of low intensity lesions in the peripheral zone.
Aged↗
Weekly CODE chemotherapy with recombinant human granulocyte colony-stimulating factor for relapsed or refractory small cell lung cancer.
We used cisplatin, vincristine, doxorubicin, and etoposide (CODE) plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) weekly for salvage chemotherapy in relapsed or refractory small cell lung cancer (SCLC). We reviewed the medical charts of patients between January 1993 and December 1996 at the National Nishi-Gunma Hospital. Twenty patients were treated with salvage chemotherapy. The overall response rate was 55.0%. The median survival time of extensive disease patients from the start of CODE therapy was 23 weeks and the 1-year survival rate was 21.0%. Toxicities were severe, especially in myelosuppression. CODE could be selected as a salvage therapy for chemotherapy- relapsed SCLC cases.
Aged↗
MR imaging of hepatosplenic sarcoidosis.
We present a case of hepatosplenic sarcoidosis. Splenic lesions were detectable by both MRI and dynamic CT. They were demonstrated as multiple low signal intensity lesions on T2-weighted images obtained by MRI and as low density lesions by dynamic enhanced CT. Hepatic focal lesions were not apparent on CT or MRI. After steroid therapy, both dynamic enhanced CT and MRI showed disappearance of the splenic lesions. These are valuable modalities for detecting focal splenic sarcoidosis and evaluating the effect of steroid therapy.
Female↗
Real-time high resolution ultrasonography of solid breast masses: use of a 10-MHz mechanical sector transducer with a water bag.
We evaluated the diagnostic accuracy of real-time high-resolution ultrasonography (RHUS) for solid breast masses, using a 10-MHz mechanical sector transducer with a water bag. A total of 103 breast nodules in 100 women were analyzed. The nodules consisted of 42 carcinomas, 10 fibroadenomas, 38 mastopathies, and 13 miscellaneous lesions. Of them, 72.8% were less than 2 cm in size. Diagnostic accuracy was correlated with the size and pathology of the nodules. Sensitivity, specificity, and accuracy were 95.2%, 83.6%, and 88.3% for carcinomas, 90.0%, 88.2%, and 88.3% for fibroadenomas, and 50.0%, 98.5%, and 80.6% for mastopathies, respectively. The overall rate of diagnostic accuracy was 74.8%. The rate of accuracy according to mass size were 87.3% (-1 cm), 87.2% (1-2 cm), 88.0% (2-5 cm) and 100% (5 cm-). False positive cases (n = 10) included seven mastopathies, two granulomas, and one fibroadenoma. False negative cases (n = 2) included one fibroadenoma and one abscess. RHUS, using a 10-MHz mechanical sector transducer, was an excellent method for the diagnosis of solid breast masses.
Abscess↗
Localization of mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase type II in human breast and its disorders.
Mineralocorticoid receptors have been detected in the normal human breast and breast cancers. The expression of mineralocorticoid receptor (MR) and 11 beta-hydroxysteroid dehydrogenase type II (11sHSD2), which confers specificity on MR for aldosterone, was examined by immunohistochemistry in 114 samples from normal human breast and benign and malignant breast lesions in order to study its possible biological significance. MR and 11sHSD2 were immunolocalized in the ductal epithelium in 39/40 (98%) and 36/40 cases (90%) of normal breast, 21/22 (95%) and 15/22 cases (68%) of fibrocystic changes, and 11/11 (100%) and 8/11 (73%) cases of fibroadenoma, respectively. Cases positive for 11 sHSD2 also expressed MR but the patterns of expression varied greatly among examples of normal breast and benign breast diseases. There was a significant correlation between labeling indices of MR and 11sHSD2 in normal breast (p < 0.01) and in benign breast disease (fibrocystic change (p < 0.05) and fibroadenoma (p < 0.05)). In invasive carcinomas, immunoreactivity for MR and 11sHSD2 was detected in malignant cells in 32/41(78%) and 16/41(39%) cases. Both MR and 11sHSD2 labeling indices were significantly higher in invasive ductal carcinoma (22 cases) than invasive lobular carcinoma (19 cases) (p < 0.01). There was a significant correlation between labeling indices of MR and 11sHSD2 when analyzing all infiltrating carcinomas (p < 0.01), but not when assessing invasive lobular or invasive ductal carcinomas separately. These results indicate that the 11 sHSD2 enzyme generally colocalizes with the MR in the ductal epithelial cells of human breast, which may allow aldosterone to occupy its physiological receptor, and the expression of MR and 11sHSD2 appears to be related to ductal differentiation of breast carcinomas.
11-beta-Hydroxysteroid Dehydrogenases↗
Immunolocalization of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human breast carcinoma.
We studied the immunolocalization of cyclins D1 and E and their corresponding partner cyclin dependent kinases (cdk), cdk4 and cdk2 in 41 cases of human breast malignancy (21 invasive ductal carcinomas and 19 invasive lobular carcinomas) and examined the correlation of the labeling indexes among these cyclins, cdks, Ki67, estrogen receptor (ER) and progesterone receptor (PR). Cyclin D1 immunoreactivity was observed exclusively in the nuclei of tumor cells in 27/41 (65%) of the cases examined. Immunoreactivity for cyclin E and cdk2 was detected in all the cases and observed in the nuclei of both carcinoma and non-carcinoma cells. cdk4 immunoreactivity was detected in 39/41 (95%) cases and found in carcinoma and non-carcinoma cells. In all carcinomas examined, a significant correlation was observed only between Ki67 and cyclin D1 (p = 0.0037). However, when examining only invasive ductal carcinomas, a significant correlation was detected between Ki67 and cyclin D1 (p = 0.0069), Ki67 and cdk2 (p = 0.0043) and cyclin D1 and cdk4 (P = 0.0024). Only cyclin D1 correlated with the pathologic stages of the disease and histological grades of invasive ductal carcinoma. Among these cyclins and cdk, overexpression of cyclin D1 is considered to play an important role in the development of human breast malignancy through abnormal proliferation. No significant correlation was observed between steroid receptor status and any of cyclins and cdks examined. Cyclin D1 and cdk2 expression correlated with cell proliferation (Ki67) and cyclin D1 expression with expression of cdk4 in invasive ductal carcinoma but not invasive lobular carcinoma. Cyclin E expression did not correlate with cell proliferation, cyclin D1 or cdks possibly due to deregulation of its expression. These results also indicate different patterns of cyclin D1, cyclin E, cdk2 and cdk4 expression between invasive ductal and lobular carcinoma of human breast.
Breast Neoplasms↗