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Biomedical subjects

R Saito

Publications and source records attributed to R Saito.

At least 325 records · Page 18Linked to original sources
PubMed1981

An adenosquamous carcinoma of the male urethra with hypercalcemia.

A case of primary adenosquamous carcinoma of the urethra observed in a 52 year old man is described. The patient had a history of recurrent scrotal abscess for seven and one-half months following trauma to the region. The serum calcium level was found to be elevated when carcinoma was diagnosed. The calcium level returned to normal after resection of the lesion but rose again when local recurrence and metastasis developed. He died three and one-half months after the surgery.

Carcinoma, Squamous Cell↗
PubMed1981

"Common channel syndrome"--anomalous junction of the pancreatico-biliary ductal system.

A 7-year-old girl with a 3-year history of intermittent bouts of abdominal pain and jaundice underwent endoscopic retrograde cholangio-pancreatography, which revealed an anomalous junction of the pancreatico-biliary ductal system (bile duct dilatation being virtually non-existent). These abdominal symptoms being considered to be attributable to the anomaly, resection of choledochus followed by hepatico-duodenostomy was performed. Now, one and a half years after operation, the patient is entirely asymptomatic. The legitimacy of "common channel syndrome" as an independent pathologic entity was proposed and the necessity of surgical treatment in its successful management was stressed.

Child↗
PubMed1981

Effect of imipramine on high potassium evoked 3H-dopamine release in the rat striatum.

The effects of three different types of dopamine (DA) uptake inhibitor, imipramine, cocaine and nomifensine, were examined on high potassium evoked 3H-DA release using tissues obtained from rat striatum by a micropuncture technique. Imipramine caused an increase in 3H-DA efflux and this imipramine-induced efflux is Ca2+-independent. Moreover, imipramine reduced the high potassium evoked release, and at 50 microM, the release by potassium stimulation was entirely abolished. These results support that imipramine depletes vesicular DA which is released by potassium stimulation as well as an inhibitory effect on DA uptake. However, nomifensine dose not have such an effect.

Animals↗
PubMed1980

Rhodamine 6G, inhibitor of both H+-ejections from mitochondria energized with ATP and with respiratory substrates.

Rhodamine 6G inhibited ATP hydrolysis by oligomycin-sensitive ATPase, purified from rat liver mitochondria, in good accord with the dose-response curve for its inhibition of energy transduction of ATP synthesis in mitochondria, but it did not inhibit ATP hydrolysis by purified F1. Rhodamine 6G also inhibited both H+-ejections from mitochondria energized with respiratory substrates and with ATP. The present findings show that the inhibitory effect of rhodamine 6G on energy transduction is not due to a modification of the transport system for adenine nucleotides, Pi, and respiratory substrates, and that the inhibition sites of rhodamine 6G are on components related with H+-ejection by redox components and also on F0.

Adenosine Triphosphate↗
PubMed1980

Anisotropic inhibition of energy transduction in oxidative phosphorylation in rat liver mitochondria by tetraphenylarsonium.

Tetraphenylarsonium (TPA+) inhibited energy transduction in oxidative phosphorylation in mitochondria but not in submitochondrial particles, which are inside-out relative to the membranes of mitochondria. TPA+ incorporated into the inside of submitochondrial particles inhibited ATP synthesis in the particles. TPA+ also inhibited the reduction of NAD by succinate coupled with oxidation of succinate by O2 and hydrolysis of ATP. Energization of mitochondrial inner membranes with succinate and with ATP induced binding sites on the membranes for TPA+. The amounts of energy-dependent binding sites for TPA+ on mitochondria energized with succinate and with ATP, respectively, were 90 and 13 nmol/mg of protein. TPA+ also caused shrinkage of mitochondria energized with succinate and with ATP in an energy-dependent fashion. The energy-dependent binding of TPA+, TPA+-induced H+-ejection, TPA+-induced shrinkage of mitochondria, and TPA+-induced inhibition of energy transduction occurred in parallel. The present findings show that TPA+ inhibits energy transduction by binding to negative charges created on lipophilic domains near the surface of the outer side (C-side) of the mitochondrial inner membranes, and that it has no inhibitory activity on the inner side (M-side) of the membranes.

Adenosine Triphosphate↗
PubMed1980

Teratogenic effects of combined administration of ethylenethiourea and nitrite in mice.

Teratogenic potential of ethylenethiourea (ETU) was investigated in SLC-ICR mice after its reaction with sodium nitrite. ETU was given orally in doses of 400 mg/kg on various days of pregnancy in combination with 200 mg/kg NaNO2 at varied intervals. When NaNO2 was given to females immediately after their treatment with ETU on day 6 or 8 of pregnancy, fetal survival was significantly decreased. Various types of malformations were observed in the living fetuses from mothers treated on day 6, 8, or 10 of pregnancy, but not on day 12. The teratogenicity disappeared when NaNO2 was given 2 h after the treatment with ETU.

Abnormalities, Drug-Induced↗
PubMed1980

Congenital pericardial defect associated with cardiac incarceration: case report.

1. A 4-year-old boy with the congenital partial defect of the left pericardium who presented with myocardial infarction, died of incarceration of the left ventricle. 2. This is the fourth reported case of death from this anomaly in the world. 3. Because this anomaly occasionally causes sudden death, it is important to diagnose the condition while the patient is alive.

Adult↗
PubMed1980

Dominant lethal mutation induced in male rats by 1,2-dibromo-3-chloropropane (DBCP).

1,2-Dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP), soil fumigants, were investigated for their potential mutagenicity by dominant lethal studies in the rat and mouse. Dominant lethal mutation was induced by DBE in neither of the species. DBCP, on the other hand, induced dominant lethals in rats in the post-meiotic stage of spermatogenesis, especially in the early spermatid stage. However, DBCP did not cause dominant lethals in mice.

Animals↗
PubMed1980

Dose-effect of inorganic tin on biochemical indices in rats.

The dose-effect of stannous chloride on biochemical indices was examined in weanling male rats given oral doses of 0.3, 1.0 and 2.0 mg/kg at 12-h intervals for 90 days. The 3.0 mg/kg dose caused significant decreases of the relative weights of the femur, calcium concentration, lactic dehydrogenase and alkaline phosphatase activities in the serum, succinate dehydrogenase activity in the liver, and calcium content and acid phosphatase activity in the femoral diaphysis and epiphysis. Of the above indices, the 1.0 mg/kg dose produced significant reduction of succinate dehydrogenase activity in the liver, and calcium content and acid phosphatase activity in the femoral epiphysis. Those significant decreases were not observed with the 0.3 mg/kg dose, although a slight but not significant decrease of calcium content in the femoral epiphysis was observed. These results suggest that the no-effect level of inorganic tin orally administered would be lower than 0.6 mg/kg/day.

Alkaline Phosphatase↗
PubMed1980

Sinus histiocytosis with massive lymphadenopathy in a Japanese adult with unusually elevated EBV antibody titers.

A 35-year-old Japanese male was presented with massive lymphadenopathy in bilateral preauricular and submandibular regions for five years' duration without any complaints despite of no specific treatments. Laboratory examinations revealed neurtrophilia, elevated BSR, hypergammaglobulinemia with elevated IgG and IgM, positive CRP and RA, low percentage of T-cells in peripheral blood, impaired PHA blast transformation, and elevated EBV titers against viral capsid, early and nuclear antigens. Biopsy specimens demonstrated massive histiocytosis with hemophagocytosis in the sinuses and predominant mature plasma cells in the medulla, which were fairly well consistent with "sinus histiocytosis with massive lymphadenopathy" (ROSAI and DORFMAN). Ultrastructural study revealed histiocytes exhibiting avid phagocytosis of blood cells, epithelioid histiocytes with poor phagocytic activity, foamy storage histiocytes loaded with a large number of osmiophilic lipid granules and giant cells of various types. Pathogenesis of this apparently benign disease entity was briefly discussed, and its refractoriness against any specific therapy was emphasized.

Adult↗
PubMed1980

Anti-inflammatory activity of a proteolytic enzyme, Prozime-10.

Prozime-10 (P-10), a proteolytic enzyme extracted from cultured broth of Aspergillus melleus, was injected intravenously into rats in dosages of 1--10 mg/kg and was found to alleviate carrageenin edema. Thermal denaturation diminished not only the proteolytic activity but also the antiedematous effect. Carrageenin-induced granuloma pouches in rats were reduced by P-10 in a dose-dependent manner (1--5 mg/kg). With P=10 (5 mg/kg i.v.), adjuvant arthritis was inhibited by 62% in the primary phase and by 57% in the secondary phase. Serum concentration of immunoprecipitable P-10 reached 100 mg/l within 30 min after the intraduodenal administration of P-10 (200 mg/kg) and was concomitant with a 3-fold increase in the blood esterolytic activity. When P-10 was injected (5 mg/kg i.v.) into rats, the plasma corticosterone level increased to a maximum of 4 times the preinjection level. These observations indicate that: (a) P-10 can be absorbed from the gut in sufficient quantities to bring about anti-inflammatory activity, and (b) the anti-inflammatory activity of P-10 can be related, in part, to the ability of P-10 to affect the release of glucocorticoids.

Adrenalectomy↗
PubMed1979

Vascular anatomy of the inner ear of the guinea pig--a sem study of the corrosion cast--.

This paper shows a casting method of the vascular system of the inner ear of the guinea pig with the use of fluid resin injected intravascularly and the observation of those specimens by means of the scanning electron microscopy. First, fluid resin was injected into the blood vessels of a live or just sacrificed guinea pig. After taking the temporal bone out of the animal, it was decalcified and macerated completely. Then, a cast of the inner ear vessels was taken and observed with a scanning electron microscope. A pair of photos differing in teh view angle by seven degrees were taken simultaneously, and observed with a stereoviewer. This technique brought photographs of well magnified three-dimensional construction of the inner ear blood vessels.

Animals↗