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Biomedical subjects

R Saginur

Publications and source records attributed to R Saginur.

27 records · Page 2Linked to original sources
PubMed1986

Nosocomial gram-negative parotitis.

Nosocomial parotitis is an uncommon postoperative complication, usually affecting elderly, debilitated, dehydrated patients. The preponderance of gram-positive pathogens has been emphasized. The authors present two cases of gram-negative parotitis and review the literature on this condition. Because the organisms producing nosocomial infection in patients receiving intensive care are commonly gram-negative bacilli, treatment should be based on the findings of Gram's staining of the pus obtained from Stensen's duct, altered when necessary by the final culture results.

Cross Infection↗
PubMed1982

Superoxol(catalase)test for identification of Neisseria gonorrhoeae.

The Superoxol (Merck & Co., Inc., Rahway, N.J.) test (catalase test using 30% H2O2) was used to differentiate Neisseria gonorrhoeae from other Neisseria species. A positive test was defined as immediate, brisk bubbling upon dropping 30% H2O2 onto a bacterial colony. One hundred percent of the gonococci were Superoxol positive. Only 1% of Superoxol-positive isolates on Thayer-Martin agar were organisms other than gonococci (99% specificity). The test was more reliable than the coagglutination test. Individual strains of a wide variety of Neisseria and Branhamella species were Superoxol positive. They could usually be differentiated from N. gonorrhoeae by their poor growth on selective media, colonial morphology on nonselective media, and simple biochemical tests. The Superoxol test is an excellent screening test for N. gonorrhoeae. A positive result on a clinical isolate growing on Thayer-Martin agar is strongly suggestive of the presence of gonococci.

Catalase↗
PubMed1980

Colitis associated with metronidazole therapy.

A 46-year-old woman was treated with oral metronidazole for trichomonal vaginitis and developed diarrhea, which persisted for five weeks. Tissue culture assay of stool supernatant showed a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin, and cultures yielded Clostridium difficile, which produced a similar or identical cytotoxin in vitro. This isolate proved sensitive to metronidazole at 0.25 microgram/ml. Prior reports have indicated that metronidazole may also be used therapeutically in patients with antibiotic-associated colitis ascribed to other agents. The patient presented here shows the enigma that the same agent used for therapy of colitis may also cause this complication.

Colitis↗
PubMed1980

Antimicrobial drug susceptibility of respiratory isolates of Hemophilus influenzae from adults.

Hemophilus influenzae isolates from sputum of 111 patients with chronic bronchitis were tested for susceptibility to 8 antimicrobial drugs. A new beta-lactam, LY-127935, was the most active agent tested. Ampicillin, cefamandole, tetracycline, and cefuroxime showed good activity against most isolates. Two strains, both nontypable, were resistant to ampicillin and produced beta-lactamase. Cefaclor was somewhat less effective, although most strains were susceptible. Erythromycin and cephalexin were of limited utility.

Adult↗
PubMed1980

Bacitracin treatment of antibiotic-associated colitis and diarrhea caused by Clostridium difficile toxin.

Four cases of antibiotic-associated colitis and diarrhea caused by Clostridium difficile were successfully treated with oral bacitracin, 25,000 units four times daily for 7-10 days. Diarrhea resolved in all of the cases, in 2 days, with disappearance of Clostridium difficile toxin in the stools in 3 out of 4 patients so measured. Two of the patients treated had relapses after vancomycin, while the other 2 were experiencing the first episodes. One patient relapsed after bacitracin treatment, but was treated successfully with vancomycin. Our preliminary experience indicates that bacitracin, being less expensive and more readily available world-wide than vancomycin, could be used as an alternative drug for toxin-induced colitis or diarrhea.

Adult↗
PubMed1973

The frequency of genetic disease and congenital malformation among patients in a pediatric hospital.

A sample of 12,801 admissions to a pediatric hospital was surveyed in 1969-70 to determine the prevalence of disease which could be classified as "genetic" in origin or related to "congenital malformation"."Genetic" admissions accounted for 11.1% of the total while 18.5% were for congenital malformations; about 2% (unknown group) were probably genetic. Therefore about one third of all admissions represent the effect of abnormal gene-environment interrelations at some point in the development or life of the patient.The "genetic" patient is admitted more often to a medical service while the patient with congenital malformation usually goes to a surgical service; the former stays 7.3 days and the latter 8.6 days. A disproportionate number of patients staying longer than 10 days were found in the group with congenital malformations. Seventy percent of the patients with multiple admissions (3.2% of all admissions) have genetic illness or congenital malformation.

Age Factors↗
PubMedDate not supplied

Group B streptococcal necrotizing fasciitis and streptococcal toxic shock-like syndrome in adults.

Necrotizing fasciitis, which is a severe and uncommon infection involving the subcutaneous tissues, is usually caused by group A streptococci. To our knowledge, however, group B streptococci (Streptococcus agalactiae) have been reported to cause necrotizing fasciitis in only 4 instances (2 involving neonates) over the past 4 decades. We report 3 cases of group B streptococcal necrotizing fasciitis in adults that occurred in southern Ontario and Quebec within a 10-month period. All 3 patients had significant underlying illness, and all required surgical debridement in addition to antibiotic therapy. One of the cases fulfilled the criteria for streptococcal toxic shock-like syndrome. Group B streptococcus has been recognized as a frequent cause of serious disease in adults. It has become evident over the past decade that invasive streptococcal infections are on the increase. We speculate that group B streptococcus has recently acquired an increased ability to cause necrotizing fasciitis and suggest that this may represent the emergence of a new clinical syndrome in adults.

Adult↗