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R Saad Júnior

Publications and source records attributed to R Saad Júnior.

10 recordsLinked to original sources
PubMedDate not supplied

[Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats].

A study was made of the changes in the cell population producing gastrin of the gastric antrum in rats submitted to resection of 80% of jejunum-ileum. Ninety days after surgery, the animals were killed after a 12 hour nightly fast and the gastric antrum was removed with the objective of specific histological preparations (PAP method) in order to count the G-cells and the blood was taken for serum doses of gastrin. An optical microscope was used to count the cells using a histometric integraded ocular of 42 points and the counting of 10 fields of each histological cut, and the radioimmunoassay method of double antibody was used for the seric dosing of gastrin. Histometry showed a significant drop in the G-cell population of the antrum of enterectomized animals when compared to the control group. Average percentage of G-cells found were 17.55% in the control group and 7.99% in the enterectomized ones. Blood dosing of hormone showed a significant increase of gastrin in the enterectomized animals when compared to controls. Average value of gastrin dosing the control group was 110 Pg/ml and 170 Pg/ml in enterectomized animals. Therefore, the present study permits to conclude that after resection of 80% of jejunum-ileum, there was a decrease in the G-cell population with gastrin in the gastric antrum even in the presence of increased serum gastrin.

Animals↗
PubMedDate not supplied

[Results of early thoracotomy in the treatment of non-calcified solitary pulmonary nodules. Analysis of 19 cases].

We reviewed 19 patients who had undergone thoracotomy and resection of a noncalcified solitary pulmonary nodule over the past 7 years, to see if a policy of early thoracotomy was therapeutically valid. The average age of patients was 50 (range 10 to 73 years), 6 females and 13 males. All of them asymptomatic. In this study, there were 9 (47.3%) of primary bronchogenic carcinoma, the incidence was 54.5% in patients above 50 years. There were no postoperative deaths and 3 serious postoperative complications (15.7%). Post operatory followed up by all patients ranged from one to seven years. The patients with benign lesions are all well. 9 of the cases had primary lung cancer, 2 died, 3 1/2 years and 5 years after surgery. We conclude that pre-operative differential diagnostic procedure between benign and malign nodules may not always be decisive, and that an early thoracotomy in indicated every case, since the incidence of malign tumors is frequent. Very small primary lung cancers detected and treated early do not have the same poor prognosis as larger primary cancers.

Adolescent↗