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Biomedical subjects

R SCHNEIDER

Publications and source records attributed to R SCHNEIDER.

At least 37 records · Page 2Linked to original sources
PubMed1960

The mechanism of the inhibitory effect of gluten fractions on the peristaltic reflex.

The mechanism of the inhibitory effect of gluten fractions on the peristaltic reflex was studied using, first, a filtrate of the autoclaved peptic-tryptic digest of gluten (fraction III A.F.) and, second, the ultrafiltrate of an aqueous extract of gluten (fraction G.U.F.). The fractions did not act as antagonists to naturally-occurring agents such as acetylcholine or substance P, but they did depress the twitch response of the isolated guinea-pig jejunum preparation stimulated coaxially. The output of acetylcholine from cholinergic nerve endings in gut was decreased during rest as well as during electrical stimulation. In large amounts, the gluten fractions depressed acetylcholine synthesis in vitro. It was concluded that the mechanism of inhibition of the peristaltic reflex by gluten fractions was chiefly by decreasing acetylcholine release.

Acetylcholine↗
PubMed1960

The inhibition of the peristaltic reflex by substances from protein sources.

An aqueous extract of gluten, and its ultrafiltrate, depressed the peristaltic reflex of the rat jejunum. This effect was shared by similar extracts of mammalian skeletal muscle but not by such proteins as casein, gelatin, and albumin. Peptic-tryptic digestion did not abolish the effect, whereas acid hydrolysis of the active fractions destroyed the depressant substance.

Animals↗