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R S Wilson

Publications and source records attributed to R S Wilson.

332 records · Page 19Linked to original sources
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Sudden blindness secondary to injections of common drugs in the head and neck: I. Clinical experiences.

Several cases of sudden, irreversible blindness have been reported in the world literature following injections of various drug combinations in the head and neck. The common feature these drugs have is their capacity to either produce direct neurotoxic effects or embolic phenomena. Two new cases which resulted from injection of the combination of a depo or long-acting corticosteroid (methylprednisolone acetate, 40 mg) and a local anesthetic and epinephrine or penicillin were added to the growing world literature. The ocular and systemic pathologic findings are described and important questions are raised as to the pathophysiology. The need for an animal model experiment to answer as many of these questions as possible is emphasized.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Sudden blindness secondary to injections of common drugs in the head and neck: II. Animal studies.

The sudden occurrence of unilateral and bilateral blindness, as reported in the literature from the personal experiences of numerous qualified investigators, occurring in humans and producing such catastrophic effects seems to mandate experimental effort to try and answer three basic questions: (1) Can an animal model be found which will demonstrate similar retinopathy for study? (2) If such a model is found, what mechanisms are involved in the production of the retinal pathologic changes? (3) What are the characteristics of the drug or drug combinations necessary to produce these pathologic changes?

Adrenal Cortex Hormones↗
PubMedDate not supplied

Diabetes mellitus, dementia, and cognitive function in older persons.

Dementia and cognitive decline are among the most common and most feared conditions of old age making the identification of modifiable risk factors for dementia an urgent public health priority. Recently, an increasing body of data suggests that type 2 diabetes mellitus, a common condition in older persons, is associated with the development of dementia and cognitive decline. A systematic review of the medical literature of the past 15 years identified 40 original-report articles in the English language pertaining to the relation of diabetes to dementia and cognitive function in older persons. Most, but not all, of these studies suggest a detrimental effect of diabetes on cognitive function. Current research efforts are aimed at understanding the underlying neurobiologic mechanisms whereby diabetes causes dementia and cognitive impairment in order to develop rational interventions to prevent this recently documented adverse consequence.

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