Biomedical subjects
R S Wadia
Publications and source records attributed to R S Wadia.
Cerebellar ataxia in enteric fever.
In a study of enteric fever, cerebellar ataxia was found to be the commonest neurological manifestation, second only to toxic delirium. Excluding toxic delirium (found in 25-30% of cases) neurologic deficit was noted in 5.0% of a series of 718 consecutive cases; 2.3% showed cerebellar ataxia, either as an isolated feature or in association with other lesions. The ataxia usually appeared in the second week, and lasted a mean of 9.4 days. In 90% of cases it had cleared completely within a month.
The Marin-Amat syndrome: an unusual facial synkinesia.
Three cases of facial nerve palsy with abnormal synkinetic movement manifesting with eye closure on jaw opening (Marin-Amat Syndrome) are described. The eye closure occurred only with wide jaw opening and it is felt that the disorder represents aberrant regeneration within the facial nerve with proprioceptive impulses associated with muscle stretch acting as the trigger. Though the movement is the exact opposite of what happens in the Marcus-Gunn phenomenon it is suggested that the term inverse Marcus-Gunn phenomenon be reserved for a congenital lesion with a different pathogenesis.
Ethanethiol sensitive & resistant antibodies to enterovirus 70 in post-conjunctivitis neurological syndromes.
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Impairment of blood-CSF barrier in patients with neurological complications following acute haemorrhagic conjunctivitis.
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Sacral agenesis.
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Cerebrospinal fluid immunoglobulins in acute transverse myelitis.
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Hepatotoxicity of antituberculous drugs.
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Prenylamine (segontin) induced resistant ventricular arrhythmias.
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Lymphocyte subpopulations in Guillain-Barre syndrome.
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Covesdem syndrome.
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Another cause of a positive crossed-straight-leg-raising test.
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Recessively inherited costovertebral segmentation defect with mesomelia and peculiar facies (Covesdem syndrome): A new genetic entity?
Two sibs of a consanguineous mating are described. Both have a gross costovertebral segmentation defect affecting nearly all the thoracic vertebrae, and mesomelia of the limbs, with the upper limbs being obviously more affected than the lower. The facial appearances of the two are identical, with hypertelorism, depressed nasal bridge, large bony upper lip, constantly open mouth, and peg-like teeth. We believe this combination has not been described before and represents the effect of a 'new' recessive gene. We would like to name this combination Covesdem syndrome (costovertebral segmentation defect with mesomelia).
Electro-diagnostic features of acute lower motor neurone paraplegia.
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CSF immunoglobulins and viral antibodies in acute transverse myelitis and Guillain-Barre syndrome.
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House pets and multiple sclerosis.
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Precordial mapping in acute myocardial infarction.
Serial precordial mapping was done in 30 patients with acute anterior myocardial infarction, 27 transmural and 3 subendorcardial. The sum of ST elevations in the 48 lead map was designated as sigma ST. Normal sigma ST was calculated as 27.1+/-3.1 in males and 14.3+/-2.8 in females. In infarction it was 100.4+/-58.2 in males and 84.8+/-50.9 in females on the 1st day of admission. Sigma ST was elevated on day 1 and tended to fall gradually. In 6 patients it was normal by day 7 and in 7 it was still abnormal by day 21. This fall roughly correlated with fall in SGOT and CPK levels. Significant elevation of sigma ST occurred in 14 of 27 cases after day 1. In 10 of 27 cases significant re-elevation occurred on day 4 or after i.e. when the patient was outside the ICCU. In 10 of the 14 re-elevations there was pain or worsening of clinical picture and in 12 there was re-elevation of SGOT. This elevation presumably implied infarct extension. There was a tendency to more arrhythmias in the patients with higher sigma ST and of the 4 deaths in the series 3 had very high sigma ST and high levels of SGOT. The patient with the highest sigma ST 295 died in cardiogenic shock. The number of risk factors was found to be higher in the high sigma ST group.