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Biomedical subjects

R S Tan

Publications and source records attributed to R S Tan.

65 records · Page 4Linked to original sources
PubMed1970

Pleural effusion and fibrosis during treatment with methysergide.

Two patients being treated for migraine with methysergide developed extensive pleural fibrosis, and in addition one of them had bilateral pleural effusions, After treatment was stopped these complications, which are thought to have been due to the drug, cleared in the next few months.

Adult↗
PubMedDate not supplied

Memory loss as a reported symptom of andropause.

Andropause seem to be less defined than menopause. This study on older patients describes how they perceive and understand this aging process. A noninterventional, cross-sectional study was performed to determine what men report as symptoms of andropause to ascertain if memory loss was a predominant feature. The hypothesis was that androgens such as testosterone are responsible for visual-spatial and memory development. As such the aging process of andropause, which is associated with declines in testosterone levels, would lead to memory loss. A standardized questionnaire of 22 questions was administered to 302 outpatients of a medical center. Information on patient demographics, understanding of andropause, and risk factors was collected. Of the 302 patients, 71% were above 60 years and whites predominated at 87%. Memory loss was reported in 36% of the patients who felt that they had experienced andropause. It was the third most common symptom after erectile dysfunction (46%) and general weakness (41%). Twenty-two percent of the 302 patients had a history of diabetes. Among those who reported that they had undergone andropause, diabetic patients were more likely to report memory loss (p = .03, OR = 1.9. CI = 1.1-3.4). Sixty-four percent of patients reported the onset of andropause to be between 50 and 70 years (the median age being 50-60 years). This study highlights the importance of testosterone in maintaining cognitive functions. It supports studies of testosterone replacement in men undergoing andropause and who have concomitant dementia. The results parallel recent reports of the neuroprotective effects of estrogens in preventing dementia. Diabetes is associated with memory loss because of the additional insults to cognitive function of the brain secondary to ischemia.

Adult↗
PubMedDate not supplied

Perceptions of and risk factors for andropause.

There has been some controversy about whether males undergo andropause (male equivalent of a menopause). This study seeks to describe how older males perceive and understand this entity. It also explores the possibility of an association between the age of onset of andropause and risk factors such as ethnic origin, smoking, alcohol, hypertension, and cerebrovascular disease. A nonexperimental, cross-sectional study was conducted at the outpatient clinic at a Veterans Affairs Medical Center. Subjects were interviewed by a single investigator and answered a questionnaire consisting of 22 items, including information on patient demographics, patient understanding of andropause, patient understanding of possible interventions with hormonal therapy, medical and drug history, and social habits such as smoking and drinking. Altogether 302 male patients were recruited: 71% of the survey population were above the age of 60 years, and 87% were white, 6% Hispanic, and 5% black. Patient knowledge of andropause was lacking, though the majority (70%) expressed an interest in getting further knowledge. The most frequent age for onset of symptoms related to andropause was 51-60 years, and patients reported symptoms such as impotence, weakness, and memory loss. The next most common age associated with onset was 61-70 years. Multivariate regression analysis revealed that smoking more than 10 cigarettes a day was independently associated with an earlier onset of andropause symptoms bringing down the age of onset to below 50 years (p = .01, OR = 2.5, CI = 1.2-5.3). We found no association with risk factors such as ethnicity or alcohol. Andropause is experienced by many older males but knowledge of the entity is nonuniform. Smokers are at risk for an earlier onset of andropause. This is the first study to look at risk factors for andropause and the results are consistent with studies in females on smoking and menopause.

Adult↗
PubMedDate not supplied

Perceptions of and risk factors for andropause.

There has been some controversy about whether males undergo an andropause (male equivalent of a menopause). This study seeks to describe how older males perceive and understand this entity and whether there is an association between the age of onset of andropause and risk factors such as ethnic origin, smoking, alcohol, hypertension, and cerebrovascular disease. A nonexperimental, cross-sectional study was conducted at the outpatient clinic at a Veterans Affairs Medical Center. Subjects were interviewed by a single investigator and administered a questionnaire consisting of 22 items, including information on patient demographics, patient understanding of the andropause, patient understanding of possible interventions with hormonal therapy, medical, and drug history, and social habits such as smoking and drinking. Altogether 302 male patients were recruited, 71% of which were above the age of 60 years, and 87% were white, 6% were Hispanic, and 5% were black. The knowledge of patients toward the entity of andropause was lacking, though the majority (70%) expressed an interest in getting further knowledge. The most frequent age of onset of symptoms related to andropause was 51-60 years, and patients reported symptoms such as impotence, weakness, and memory loss. The next most common age reported to he associated with age of onset was 61-70 years. Multivariate regression analysis reveals that smoking more than 10 cigarettes a day was independently associated with an earlier onset of symptoms of andropause, bringing down the age of onset to below 50 years (p = .01, OR = 2.5, CI = 1.2-5.3). We found no association with risk factors such as ethnicity and alcohol. Andropause is experienced by many older males but knowledge of the entity is nonuniform. Older males are at risk for an earlier onset of andropause if they were smokers. This is the first study looking at risk factors for andropause and the results are consistent with studies in females on smoking and menopause.

Adult↗
PubMedDate not supplied

Cardiovascular applications of magnetic resonance flow measurement.

Magnetic resonance flow measurement is a technique that can be applied in many areas of cardiovascular diagnosis. It is unique in its ability to acquire comprehensive velocity and spatial information, which makes it an accurate quantitative tool. In the evaluation of valvular heart disease and congenital heart disease, use of MR flow imaging is well established. In the assessment of coronary artery disease, MR quantification of coronary flow, in conjunction with other MR techniques, makes MR imaging a highly versatile diagnostic imaging modality. This article will review the clinical applications of MR flow measurement, as well as cover some of the basic physical principles underlying the technique, and the associated technical limitations.

Coronary Circulation↗