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Biomedical subjects

R S Panush

Publications and source records attributed to R S Panush.

135 records · Page 8Linked to original sources
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Adenovirus arthritis.

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Adenoviridae↗
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Effects of certain antirheumatic drugs on normal human peripheral blood lymphocytes. Inhibition of mitogen- and antigen-stimulated incorporation of tritiated thymidine.

The effects of antirheumatic drugs on in vitro responses of normal human peripheral blood lymphocytes were examined and found to affect phytomitogen, antigen, and mixed lymphocyte responses. The drugs and concentrations (mumg/ml) at which 50% inhibition (ID50) of phytomitogen stimulation occurred were acetylsalicylic acid, 80; phenylbutazone, 150; indomethacin, 250; sodium aurothiomalate, 200; hydroxychloroquine, 75; D-penicillamine, 400; hydrocortisone, 50; naproxen, 350; and sodium meclofenamate, 175. Acetaminophen enhanced blastogenesis by 100% at 200 mug/ml, but was 50% inhibitory at 500 mug/ml. Other drugs had no effects. Numbers of viable cells in cultures with and without mitogens and drugs were generally similar at beginnings and ends of experiments. Stimulated cell cultures containing combinations of drugs exhibited greater inhibition than did cultures of individual drugs. Inhibition by drugs was greater when cells were cultured in medium alone than in medium with 20% plasma. Cells exposed overnight to phenylbutazone, indomethacin, sodium aurothiomalate, or sodium meclofenamate, then washed and stimulated, responded generally as well as did cells not exposed to drugs. Because some of these drugs exhibited effects at concentrations approaching therapeutic levels, these findings may be pertinent to clinical investigations of cellular immune responses of patients on drug therapy and to possible mechanisms of action for certain drugs.

Anti-Inflammatory Agents↗
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Exercise and arthritis.

Recreational exercise has achieved great popularity. Possible benefits to participants are increased longevity, decreased risk of cardiovascular disease, improved psychological well-being, and greater fitness. A very important but as yet unanswered concern is whether regular exercise will lead to degenerative joint disease or osteoarthritis. Many factors (e.g. physical characteristics of participants, biomechanical and physical features, nature of the playing surface and sport, manner of participation, preventive measures, and certain medical considerations) might influence the risk of developing osteoarthritis from sports participation. However, none of these have been evaluated. Although studies with animals have identified situations in which articular cartilage degeneration may be accelerated, experimental observations have not found normal joint motion in exercising animals to be harmful to joints. Anecdotal observations in man have suggested relationships between recreational activities and degenerative joint disease. However, those few controlled studies reported indicate that exercise need not be deleterious to joints. We interpret available data as suggesting that reasonable recreational exercise, carried out within limits of comfort, putting joints through normal motions, without underlying joint abnormality, even over many years, need not inevitably lead to joint injury.

Adult↗
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Factitial Weber-Christian disease: a case report.

A 28 yr old white woman with fevers, arthralgias, and panniculitis was found to have factitial Weber-Christian disease induced by repeated subcutaneous injections of paint. The characteristics of self-induced dermatoses, various agents used in their production, and the psychodynamics of patients with self-induced illnesses are discussed. It is important that this diagnostic possibility be considered in patients presenting with obscure constitutional, musculoskeletal, and cutaneous findings.

Adult↗
PubMedDate not supplied

Inhibition of human lymphocyte responses by methylmethacrylate.

The in vitro response of normal stimulated human peripheral blood lymphocytes to methylmethacrylate (MMA) was a dose related inhibition. Fifty per cent inhibition occurred at concentrations of 0.078-0.125%. MMA affected not only responses to soluble phytomitogens but also responses to specific antigens and allogeneic lymphocytes. Numbers of viable cells in cultures with and without mitogens and MMA were comparable at the beginning and end of experiments, excluding methacrylate-related cytotoxicity as the primary mechanism of inhibition of lymphocyte responses. Inhibition did not result from alteration of kinetics of lymphocyte responses. Inhibition was greatest when MMA was added during early phases of cellular activation. It also reduced the ability of T-lymphocytes to rosette with sheep erythrocytes. These data indicate that MMA causes noncytotoxic, incompletely reversible inhibition of nonspecific, specific, soluble, and insoluble stimulated lymphocyte responses and rosette formation in vitro.

Antigens↗