The historical and geomedical immunogenetics of pemphigus among the descendants of Sephardic Jews in New Mexico.
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HLA-DQ Antigens↗
Biomedical subjects
R S Padilla
Publications and source records attributed to R S Padilla.
Use of a topical fluorescent dye to evaluate effectiveness of sunscreen application.
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Administration, Topical↗
Pigmented basal cell carcinoma in Hispanics.
BACKGROUND: Pigmented basal cell carcinoma (PBCC) may occasionally be misdiagnosed as melanoma. In the Hispanic population, PBCC is common. OBJECTIVE: We attempted to determine the prevalence of PBCC in a Hispanic population. METHODS: A randomized, blinded, retrospective study was designed to assess histologic slides for the presence of microscopic pigment. Basal cell carcinoma (BCCs) from 30 patients with a Hispanic surname were compared histologically with BCCs from 30 patients with a northern European surname. In the prospective phase of the study, 15 Hispanic and 44 non-Hispanic patients with clinically suspected BCC or PBCC completed a questionnaire about their ethnic background and skin type to determine whether PBCC is more common in Hispanics. RESULTS: Pigment was identified twice as frequently in BCCs from patients with a Hispanic surname than in BCCs from patients with a northern European surname. In the prospective clinical study, 66% of clinically diagnosed PBCCs were found in Hispanic patients, whereas only 11% of nonpigmented BCCs came from Hispanic patients (p < 0.01). CONCLUSION: In patients with a BCC, PBCCs are more common in Hispanics than non-Hispanics. This may reflect an increased incidence of PBCCs in the Hispanic population.
Basal Cell Carcinoma↗
Malignant schwannoma treated by Mohs surgical excision.
A 34-year-old white female with a 5-cm malignant schwannoma of the upper thigh underwent complete removal of the tumor by fresh-tissue Mohs surgical excision. The patient refused postoperative radiotherapy, and is without signs of recurrence 5 years after surgery. Mohs surgical excision in the treatment of malignant schwannoma has not to our knowledge been reported previously.
Adult↗
Linear focal elastosis (elastotic striae).
Three patients are described who had a distinctive clinical and histologic presentation of dermal elastosis. Sunlight apparently played little role in the development of this elastotic change. To the best of our knowledge, this is the first report of this form of elastosis.
Aged↗
Carbon dioxide laser vaporization: relationship of scar formation to power density.
A direct relationship exists between the power density of a carbon dioxide laser and the thickness of scars it produces in rat skin. Statistically significant positive relationships were noted between laser power and scar thickness at days 14, 21, and 32. The slope of the curve increased as the number of days elapsed. At day 32, the ratio of scar thickness to CO2 laser power density delivered was 0.3 microns/W-cm2. Scar formation took longer for completion at higher wattages of irradiation.
Animals↗
Ultraviolet radiation--induced malignant melanoma in Monodelphis domestica.
Several lines of evidence support the hypothesis that ultraviolet radiation (UVR) is involved in the etiology of cutaneous melanoma in humans. However, progress in understanding the mechanisms involved in induction of melanotic tumors by UVR has been hindered by lack of a suitable animal model. During the course of multiple exposures (3 times/wk for 70 wk) of the South American opossum, Monodelphis domestica, to UVR, we first observed the appearance of areas of dermal melanocytic hyperplasia (MH) on the exposed skin. Post-UVR exposure to photoreactivating light (320-500 nm) suppressed the occurrence of MH. We also observed at 100 weeks from first exposure that 10 of 46 surviving animals had developed melanotic tumors which arose, presumably, from areas of MH. Tumors on three of the 10 animals have been classified as malignant melanomas based on metastasis to lymph nodes. We conclude from these results that UVR can act as a complete carcinogen for melanoma induction and, based on the photoreactivation of MH induction, that DNA damage is involved in melanoma formation.
Animals↗
Malignant melanoma arising in a giant congenital melanocytic nevus. A case report with cytogenetic and histopathologic analyses.
A malignant melanoma developed in a 2-year-old Hispanic girl with a giant congenital melanocytic nevus (bathing-trunk type). Histopathologic evaluation showed a deep-seated tumor arising from a nonepidermal origin. Cytogenetic analysis demonstrated multiple chromosomal abnormalities in hyperdiploid cells (chromosome range, 56 to 61). No two karyotypes were identical, but many abnormalities were common to all analyzed cells, suggesting both karyotypic instability and evolution. The metaphases were monosomic for 3, 12, and 16, trisomic for 1, 2, 8, 19, 20, and 21, and included structural aberrations deletion 1 and derivatives 3 and 16. Eight markers were identified, including one ring. The extra 19 was possibly an isochromosome. No abnormalities of 6 or 10 were identified.
Chromosome Aberrations↗
Acquired "tufted" angioma (progressive capillary hemangioma). A distinctive clinicopathologic entity related to lobular capillary hemangioma.
Three young patients affected by intradermal and subcutaneous vascular proliferations are presented. The lesions were acquired and developed as solitary or multiple erythematous patches and plaques in the upper thorax, neck, and scalp. Light-microscopic examination revealed a deep-seated vascular growth with a distinctly lobular pattern. Ultrastructural and immunocytochemical studies demonstrated the cellular proliferation to be composed of endothelial and perithelial cells, the latter predominating. These cases are interpreted as examples of the vascular disorder described as progressive capillary hemangioma and acquired "tufted" angioma. We believe that it represents a distinctive clinicopathologic entity that is closely related histogenetically and perhaps pathogenetically to the entity recently renamed lobular capillary hemangioma.
Adolescent↗
Ovarian adenocarcinoma presenting with the sign of Leser-Trélat.
A 76-year-old woman with ovarian adenocarcinoma and sudden onset of many seborrheic keratoses is reported. This cutaneous sign, a marker of an internal malignancy, is known as the sign of Leser-Trélat. Its association with gynecologic neoplasms is reviewed.
Adenocarcinoma↗
Technetium antimony sulfur colloid scintiscan in selective lymph node dissection for malignant melanoma.
Lymphoscintigraphy with Technetium antimony sulfur colloid (TASC) was used in four patients with malignant melanoma to identify the pattern of lymphatic drainage, allowing selective lymph node dissection. TASC is safe and predictive of lymph node drainage patterns. Using this technique allows visualization of multiple tiers of lymph nodes in 2 to 6 hours.
Adult↗
Epithelioid sarcoma. Enzymatic histochemical and electron microscopic evidence of histiocytic differentiation.
A 63-year-old man had epithelioid sarcoma. Light microscopy showed the tumor to resemble granuloma annulare. Enzymatic histocytochemical and ultrastructural studies demonstrated the tumor's histiocytic features. Literature review of epithelioid sarcoma and granuloma annulare showed them to have a similar anatomic distribution.
Histiocytes↗
Serum lysozyme in patients with localized and generalized granuloma annulare.
Serum lysozyme (Muramidase) levels in patients with localized and generalized granuloma annulare were measured by a turbidometric method. More lysozyme is present in the serum samples of patients with generalized granuloma annulare than patients with the localized form or normal controls. The mean level of patients with generalized disease was 9.27 mg/L compared with 5.96 mg/L for patients with localized disease and 6.8 mg/L for controls.
Adolescent↗
Verrucous carcinoma of the skin and its management by Mohs' surgery.
Verrucous carcinoma is a low-grade squamous cell cancer that can invade many anatomic sites. Since its clinical appearance is easily confused with several benign conditions, reliable diagnosis is by biopsy and histopathologic examination. The Mohs' histographic surgical technique provides complete surgical excision and a high incidence of cure.
Adult↗
Differential staining pattern of lysozyme in palisading granulomas: an immunoperoxidase study.
Biopsies from palisading granulomas of granuloma annulare, necrobiosis lipoidica, and rheumatoid nodules were examined for the presence of lysozyme (muramidase). This enzyme was identified in paraffin-embedded tissues using a primary antibody to lysozyme and the peroxidase-antiperoxidase technic. Some inflammatory cells in the infiltrate of granuloma annulare stained abundantly for lysozyme, whereas those of necrobiosis lipoidica and rheumatoid nodule stained minimally and negatively, respectively. This pattern of staining may be of diagnostic value and suggests that the histiocytoid cells constituting the infiltrate of granuloma annulare are in some way different from the similar-appearing cells of necrobiosis lipoidica and rheumatoid nodule.
Granuloma↗
Cutaneous metastatic adenocarcinoma of gallbladder origin.
Cutaneous metastases developed in a 74-year-old woman from an adenocarcinoma of the gallbladder. A biopsy specimen of a cutaneous nodule showed the presence of systemic cancer. Results of a histopathologic examination, along with the autopsy findings, established that the cutaneous metastasis was of gallbladder origin. This article reports the extreme rarity of metastases from a cancer of the gallbladder to the skin.
Adenocarcinoma↗