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Biomedical subjects

R S Neill

Publications and source records attributed to R S Neill.

9 recordsLinked to original sources
PubMed1987

Venous plasma (total) bupivacaine concentrations following lower abdominal field block.

Following local anaesthesia of the lower abdominal wall, in patients undergoing laparoscopic sterilization (n = 16), using 0.5% plain bupivacaine 40 ml (n = 8), or 0.5% bupivacaine with 1:200000 adrenaline (n = 8), venous plasma (total) bupivacaine concentrations were measured (gas-liquid chromatography) at intervals up to 2 h after the local anaesthetic was injected. Mean peak plasma venous concentration achieved following 0.5% plain bupivacaine was 2.23 +/- 0.24 micrograms ml-1 (mean +/- SEM), while the mean peak concentration following 0.5% bupivacaine with adrenaline was 0.98 +/- 0.10 micrograms ml-1 (mean +/- SEM). At all sampling times up to and including 45 min after the injection of local anaesthetic, the plasma concentrations were significantly less in the bupivacaine with adrenaline group when compared with the group in whom a plain solution was used.

Abdominal Muscles↗
PubMed1984

Plasma bupivacaine concentrations during combined regional and general anaesthesia for resection and reconstruction of head and neck carcinomata.

Venous plasma bupivacaine concentrations were measured in patients undergoing resection and reconstruction surgery for intra-oral malignancy. Vth cranial nerve and cervical plexus blocks were performed using 0.5% bupivacaine. Total dosage was higher than recommended by U.K. manufacturers. Mean peak venous plasma concentrations were higher than previously recorded. A significant different was found in the peak concentrations when adrenaline was included. The significance of these results in relation to systemic toxicity and recommended dosage is discussed.

Aged↗
PubMed1980

Progressive systemic sclerosis. Prolonged sensory blockade following regional anaesthesia in association with a reduced response to systemic analgesics.

The anaesthetic history of a patient with progressive systemic sclerosis is reported. On each occasion large amounts of systemic analgesics were required to control pain after operation. Regional nerve block produced prolonged periods of sensory anaesthesia. Both of these features are attributed to the effect of the disease process on the peripheral vasculature. It is suggested that advantage should be taken of the prolongation of sensory anaesthesia to help control postoperative pain in such patients.

Adult↗
PubMed1978

Postoperative analgesia following brachial plexus block.

The time from the end of surgery to the administration of the first post-operative analgesic has been measured in 86 patients following brachial plexus block with bupivacaine, lignocaine, nepivacaine or prilocaine. A signficant increase in time occurred with bupivacaine; the combination of regional and general anesthesia significantly increased the time when compared with general anaesthesia in the same patient. In children, the use of regional anaesthesia almost removed the need for analgesia after surgery.

Adolescent↗
PubMedDate not supplied

Ablation of the brachial plexus. Control of intractable pain, due to a pathological fracture of the humerus.

A case report is presented which illustrates the difficulties in providing control of intractable pain from pathological fractures of the humerus. Relief from large and frequent doses of systemic analgesics was found to be inadequate. Control was achieved using brachial plexus block with bupivacaine combined with absolute alcohol. The decision to partially ablate the plexus is considered to be justified by the improved quality of life which the patient enjoyed.

Brachial Plexus↗