Syphilis in art: an entertainment in four parts. Part 3.
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Biomedical subjects
Publications and source records attributed to R S Morton.
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The need to improve the function of public health services to control sexually transmitted disease (STD) is presented. Improved public health service function in the United Kingdom calls for an improved administrative structure; a 10 year programme of development is envisaged. The threat of a heterosexually based epidemic of infection with human immunodeficiency virus (HIV) offers an opportunity to improve the control of STD generally.
Reports published in the past twenty years include many purporting to show, without much reason, that classic presentations of neurosyphilis are the exception rather than the rule. We join the few who take another view, and discuss here the reasons underlying the conflict of opinions.
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It is easy to overlook work that is before its time, especially if it has been done in the recent past. In his animal experimental work with Chlamydia spp, the late Dr E. Weston Hurst found that although he was able to effect a clinical cure in his intraperitoneally infected mice, he was unable to eradicate their infections. As his work appears to have relevance to today's growing problems concerning genital infections associated with chlamydiae, it should not fall into obscurity.
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Recent developments in syphilis serology are set down. The approach today is more rational as it has some basis in immunological understandings. In spite of improvements, syphilis serology continues to have limitations, and differentiating active from inactive cases remains taxing. In primary and secondary syphilis, dark-ground microscopy is still the quickest and surest way to make the diagnosis. In latent syphilis and in late and congenital cases, as well as in instances of other treponemal infections, serological evidence of disease needs to be considered along with each patient's medical, social and sexual history, when and why they may have been given antibiotic treatment, and the results of radiological studies and cerebrospinal fluid examination. For some syphilitics, the decision to treat or not to treat remains a matter of art rather than science.
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Prostitution in Sheffield, a city with over half a million population, has been reviewed in its legal, social work, and medical aspects. The years studied were 1960-73. The medical studies were confined to the years 1968-72. Prosecutions for soliciting increased steadily during the study period. The trend was more marked locally than nationally and was associated both with increased police activity and, more recently, with the pursuit of a socially-aware sentencing, probationary, and social work policy. During the 5-year medical study, sixty prostitutes were seen. Using gonorrhoea as an index they were found to hazard the health of both themselves and others. Recurrent infection was the rule amongst them and 40 per cent. suffered salpingitis. In epidemiological terms our findings show that the vector role of prostitutes continues undiminished. The alleged decline in their role is relative only and not real. They accounted for one in six of locally acquired gonococcal infections in heterosexual men. The study indicates the need for the regular monitoring of the social phenomenon or prostitution and for the detailed study of all its aspects on a national basis.
A study of the occurrence of Clostridium difficile in the urogenital tract of males and females revealed higher isolation-rates in patients attending the special (venereal-disease) clinic than in patients attending family-planning and urological clinics. The presence of Cl. difficile in patients with venereal diseases is being investigated to see if the organism is simply an opportunist infecting a urethra disturbed by some antecedent disease, or if it is perhaps a primary cuase of disease.
By means of a standard lymphocyte microcytoxic technique, the tissue types were fully determined in 41 patients with non-gonococcal urethritis and 25 patients with Reiter's syndrome. The antigen HL-A27 was identified in 14 of the patients with Reiter's syndrome and occurred in 3 of the patients with non-gonococcal urethritis. An excess of the genotype HL-A27/W10 was found in patients with Reiter's syndrome. There was no correlation between the duration or the severity of the clinical manifestations of the syndrome and the presence of the antigens. The possibility that the syndrome might result from various pathogenic mechanisms is discussed.
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A total of 250 women, 100 of them named contacts of men with gonorrhoea, were tested for infection. Each had prepared smear and culture specimens from urethra, endocervix, and vagina. The smears were Gram-stained and examined immediately. Cultures were taken using Stuart's transport medium with later inoculation of both selective and non-selective media for each specimen.It was shown that examination of specimens from urethra and endocervix gave results superior to those found on examination of vaginal material alone. The study revealed that nearly one infected woman in three would have been missed if vaginal material only had been examined. Failure to secure a prompt scientific diagnosis has serious epidemiological implications.Our results find support in the work of others. We conclude that the suggestion in some quarters that examination of vaginal material for the detection of gonococci is adequate should be abandoned. Any who feel unwilling to accept this view should at least supplement their testing with examination of urethral and endocervical specimens.