Search PubMed⌕ Search

Biomedical subjects

R S Matthews

Publications and source records attributed to R S Matthews.

28 records · Page 2Linked to original sources
PubMed1977

Observations on the antibody rsponses in molluscum contagiosum.

A survey of the incidence of molluscum contagiosum virion antigens in patients with single or multiple lesions showed that all lesions contain virus antigen. The virion antigens were detected in the prickle cell, granular and keratin layers. Hyperimmune sera against vaccinia, rabbit-pox and mouse-pox failed to stain the inclusion bodies in molluscum contagiosum lesions. Virus-specific antibodies were present in 69% of the patients. Although virus-specific IgG antibody was predominant, virus-specific IgM and virus-specific IgA were found in a few patients. An IgM staining in the prickle cell, granular and keratin layers of normal skin adjoining the molluscum contagiosum lesion was observed. The virus-specific antibody response was induced in a few patients after the treatment.

Antibodies, Viral↗
PubMed1975

An immunofluorescence study of warts.

An investigation of the incidence of wart virus-specific antibody and of virion antigens in patients with single or multiple warts taken from different anatomical sites showed that all warts did not contain antigen. The incidence was identical using either rabbit antiserum or human sera known to contain virus-specific antibody. The warts from sole, heel and toe had a much higher incidence of stainable virus antigen. Virus-specific staining was mainly found in the keratinized and granular layers of the wart but occasional synthesis in prickle cell layer was observed. All the patients who had virus antigens in their warts did not have virus-specific antibodies but no patient who had antibody lacked antigen. Of the virus-specific antibodies, the IgM class was predominant; a smaller number also contained virus-specific IgG antibody; none had virus antigens and both classes of virus-specific antibody. A wart cell-specific IgM was also found along with virus-specific antibodies and independent of them. An IgM producing fibrillar Staining in human embryonic lung cells was noted in some sera.

Antibodies, Viral↗
PubMedDate not supplied

The G-excess effect.

Explore the source record for details and available documents.

Accidents, Aviation↗
PubMedDate not supplied

The value of tests of cure following cervical chlamydial infection.

Test of cure (TOC) was performed 2, 4 and 6 weeks after treatment for cervical chlamydia infection with 10-14 days of Deteclo one tablet twice daily, erythromycin 500 mg twice daily or doxycycline 100 mg twice daily. Testing was by chlamydia culture and IDEIA (DAKO diagnostics Ltd). Discrepant results were subsequently checked by immunofluorescence (Syva MicroTrak) of both sets of left over transport media. Two hundred and three patients attended on at least one occasion; 189, 146 and 107 at 2, 4 and 6 weeks respectively. Of these 127, 70 and 34, respectively, denied sexual intercourse or had consistently used condoms. Fourteen were positive over the study period by either or both methods of detection. Of 8 culture positive results 3 were negative by IDEIA. Two of these had elementary bodies (EBs) on immunofluorescence of both sets of saved transport media. One had EBs on immunofluorescence of the saved culture transport medium only. None of the 6 IDEIA positive, culture negative patients had immunofluorescent EBs in the IDEIA transport media although one had EBs in the saved culture transport medium. One IDEIA suspicious, culture negative patient had EBs in both sets of saved transport media. There was no significant difference in the rate of chlamydia detection from patients admitting to or denying unprotected intercourse. TOC has a low yield in cases of cervical chlamydial infection when there has been careful contact tracing and treatment has been completed. If TOC is performed culture should be used if available and where antigen detection methods are used confirmation should be sought for any positive results.

Chlamydia Infections↗