Biomedical subjects
R S Manor
Publications and source records attributed to R S Manor.
Ocular changes in invasive osteogenic sarcoma of the skull.
Serial narrow-band green-light fundus photographs documented the evolution of descending optic atrophy in a case of rapid bilateral blindness produced by a highly invasive osteogenic sarcoma of the base of the skull. Disappearance of the nerve fiber layer (NFL) was observed to take place between the sixth and 12th week after onset of blindness; thus, it is similar to the evolution of descending atrophy found to occur in clinical cases of blindness caused by traumatic involvement of the optic nerve. Parallel to the disappearance of the NFL there was an increase in optic nerve head excavation and a change in the appearance of the vessels on the disk surfaces.
Transient retinal ischaemia induced by nifedipine.
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Diencephalic syndrome due to a suprasellar epidermoid cyst. Case report.
A 5-year-old child with the unusual association of late-onset diencephalic cachexia and pituitary insufficiency is described. At operation a suprasellar epidermoid cyst was found and excised. This curable tumor should be added in the differential diagnosis of diencephalic syndrome.
Pupil cycle time in noncompressive optic neuropathy.
Pupil cycle time was found to correlate with the clinical findings in 24 patients with noncompressive optic nerve pathology, including 11 cases of multiple sclerosis. Furthermore, subclinical multiple sclerosis was detected by the prolongation of pupil cycle time and was confirmed by visual evoked potential analysis. There was a correspondence between dynamics in the clinical findings and the pupil cycle time in two cases of multiple sclerosis that were followed up.
Pupil cycle time in space occupying lesions of anterior optic pathways.
Twenty-nine patients with presumed compressive optic neuropathy were studied, and pupil cycle times were measured. We found (1) normalcy of the test in cases of space-occupying lesion without suprasellar extension or after successful operation; (2) prolongation of pupil cycle time in cases of subclinical disorder conformed by visual evoked responses as well; (3) a good correlation between the values of prolonged pupil cycle time and degree of involvement of the visual field in pathological cases.
[Posterior uveitis in multiple sclerosis].
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[Delays in diagnosis of space occupying chiasmal lesions].
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[The diagnosis of space occupying chiasmal lesions].
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Myopia during bromocriptine treatment.
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Narrow-band (540NM) green-light stereoscopic photography of the surface details of the peripapillary retina.
We used narrow-band (540-nm) green-light stereoscopic fundus photography to study the surface details of the peripapillary retina in 14 patients. Each photograph was divided into four areas; the papillomacular bundle, the upper arcuate bundle, the lower arcuate bundle, and the nasal sectorial fibers. We scored each area on a scale of 0 (normal) to 3 (total loss of nerve fiber layer), and compared these scores to those obtained by testing the corresponding visual fields. The scores were the same in 88 of 111 comparisons; the retinal scores were higher in 17 comparisons and the visual field scores were higher in six comparisons. This photographic technique makes the nerve fiber layer easier to see and evaluate and the detection of defects becomes less difficult.
The pupil cycle time test: age variations in normal subjects.
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Pituitary apoplexy during carotid angiography.
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Nasal visual field loss with intracranial lesions of the optic nerve pathways.
Five patients developed nasal visual field defects as a result of involvement of the intracranial portion of the optic nerves. The cause in each patient, respectively, was as follows: (1) dolichoectatic carotid arteries, (2) optochiasmatic arachnoiditis, (3) meningioma of the olfactory groove, (4) pituitary apoplexy, and (5) pituitary chromophobe adenoma. The common factor in these cases was probably impaired circulation in the prechiasmal arterial anastomotic network. The nasal visual field loss present in these cases was characterized by a pattern similar to that seen in glaucoma but with impairment of visual acuity. The superior nasal visual field was usually normal and the lower temporal visual field often defective.
Use of special glasses in treatment of spasm of near reflex.
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Cell mediated immunity to human myelin basic protein in Vogt-Koyahagi-Harada syndrome.
An immunological basis for neurological involvement in Vogt-Koyanagi-Harada syndrome was sought by means of the migration-inhibition factor technique with human myelin basic protein. The test was carried out in four patients who had recent manifestations of the syndrome, two of whom were evaluated both before and after initiation of steroid treatment; in one patient 4 years after recovery from the syndrome; in three patients having uveitis of other causes, and in 12 healthy controls. The results were positive in all four patients who had recent manifestations, whereas they were negative in all the others. This finding may constitute evidence of a cell-mediated immunity toward components of the nervous system in this disease entity.
Visual fields in metastatic choroidal carcinoma.
A large choroidal metastasis was diagnosed in the right eye of a 44-year-old man referred for admission to hospital because of 'retinal detachment.' At the same time in the second, symptomless, eye a very small metastasis was observed. Close follow-up during the next month showed an extremely rapid deterioration of visual acuity and visual field in this eye. This is thought to be characteristic of such metastatic tumours in contrast to the slower progress of choroidal malignant melanoma. The application of local radiotherapy to the same eye led to an impressive improvement in the visual acuity and visual field. The source of these bilateral choroidal metastases, which was found only after the patient's death, proved to a bronchial carcinoma.
Inhibition of macrophage migration by choroidal malignant melanoma-associated antigens in patients with unveal melanoma.
The specific cell-mediated immunity of the lymphocytes of eight patients with choriodal malignant melanoma (MM) to four extracts of choroidal MM-associated antigens was tested with the aid of the MIF technique. Seven of the patients with choroidal MM responded to at least one of the four extracts used, whereas patients with choroidal nevus or carcinoma as well as healthy controls did not respond to any of the MM choroidal extracts. There was no response to iris extracts obtained from the enucleated eyes with MM in any of the subjects tested.