Changes in plasma transferrin levels following the adminstration of iron.
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Biomedical subjects
R S Lane
Publications and source records attributed to R S Lane.
Discomfort and disability in upper respiratory tract infection.
Ambulatory patients with upper respiratory infection were studied to determine the relative contributions made by tissue pathology, psychologic and perceptual attributes, and demographic characteristics to reported discomfort and disability. Patients (n = 115) attending a medical walk-in clinic completed self-report questionnaires to assess somatization, anxiety, depression, hostility, amplification, discomfort, disability, and demographic characteristics. Clinicians rated the extent of disease apparent on physical examination. Using stepwise multiple regression, demographic factors and physical findings explained 25% of the variance in reported discomfort. The addition of somatization scores increased the variance explained to 49%. The best model, including somatization and amplification, accounted for 54% of the variance. A model composed of demographic characteristics, physical findings, and somatization accounted for 25% of the variance in reported disability. The authors conclude that psychologic variables are important in the experience of discomfort, even after the extent of physical disease and demographic characteristics have been taken into account.
Activities of Daily Living↗
Empiric antacids and reassurance for acute dyspepsia.
The evaluation of ambulatory patients with dyspepsia frequently includes upper gastrointestinal radiographs (UGIs), a practice of unproven value in low-risk patients. To assess an alternative management strategy without UGIs, 28 patients with upper abdominal pain seen in an adult medical walk-in practice were treated with high-dose antacid therapy for three weeks. The clinical course on antacid therapy was good; 68% of patients reported substantial improvement. Initial requests for UGIs were high among both patients and physicians. Following empiric antacid therapy, requests for UGIs fell from 68% to 32% for patients (p = 0.05) and from 71% to 21% for physicians (p = 0.001). No serious complications were detected after 18 months of follow up. Direct medical charges were reduced by 37%. Empiric antacid therapy for patients at low risk for serious disease relieves dyspepsia and reduces both patient and physician requests for UGIs.
Adult↗
The amplification of somatic symptoms.
We studied the role of somatosensory amplification, as measured by a self-report questionnaire, in symptomatology, overall discomfort, and disability in 115 patients with upper-respiratory-tract infections who visited an adult medical walk-in clinic. Multiple regression analyses indicated that amplification was a statistically significant predictor of the patients' localized but not systemic symptoms, of reported overall discomfort, and of their social and vocational disability. These relationships held true while controlling for differences in medical morbidity and sociodemographic characteristics. Amplification was closely related to, but distinct from, three measures of dysphoria: depression, anxiety, and hostility. The tendency to amplify a broad range of bodily sensations may therefore be an important factor in experiencing, reporting, and functioning with an acute and relatively mild medical illness.
Adult↗