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Biomedical subjects

R S Kirk

Publications and source records attributed to R S Kirk.

At least 19 recordsLinked to original sources

The laboratory maintenance of Sanguinicola inermis Plehn, 1905 (Digenea: Sanguinicolidae).

Methodology is described for the laboratory maintenance of the life-cycle of Sanguinicola inermis, using common carp (Cyprinus carpio) as the definitive host and Lymnaea peregra as the intermediate host. Lymnaea auricularia was also infected but is not considered to be a suitable laboratory host. Tench (Tinca tinca) were susceptible to infection at high cercarial doses but subsequent infection rates were low. Goldfish (Carassius auratus) and Lymnaea stagnalis were refractory to laboratory infection.

Animals

Investigation of possible changes in the detection of cervical carcinoma in patients of Dutch general practitioners.

In a series of 430,015 cervical smears made by general practitioners and coming from all regions of the Netherlands in the period 1972-1980, no significant changes were noted in the rates of positive smears (Papanicolaou IV and V). These data are especially relevant in deciding the age limits for the cytology health service programs. Women aged more than 55 years contribute only 5% of the smears made by house doctors: nevertheless, this group had just as many cases of invasive carcinoma as the younger group. Since 1974 there has been an increase in the diagnosis of adenocarcinoma in situ of the endocervix, probably due to better knowledge of the cytologic and histologic criteria of this lesion. The effects of underdiagnosis of this carcinoma precursor are stressed. It is concluded that it is more important at present to concentrate any additional cytological screening on the "forgotten group" of women aged over 55 years and not yet to extend health survey programs to women under 35 years. However, this policy may need to be reviewed if increased rates of preinvasive tumor in the future lead to an earlier average age for invasive tumor.

Adenocarcinoma

A comparison of thiomersal and 50% alcohol as preservatives in urinary cytology.

The efficacy of 50% ethyl alcohol and of thiomersal as preservatives in urinary cytology were compared. In both methods over 80% of the cells were sufficiently well preserved after three days to allow cytomorphological evaluation, and over 50% on the seventh day. In the specimens without preservative, only 54% and 28% were intact after the same time intervals. In contrast with 50% ethyl alchohol, thiomersal is a more effective bactericide, it does not increase the volume of the sample, it is cheaper, and it does not affect the cytomorphology.

Bacteriuria

Birth control.

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Birth Rate

The association between aneurysm of the abdominal aorta and peptic ulceration.

In a survey of 7,044 necropsies there were 99 cases of aneurysm of the abdominal aorta and 523 cases of peptic ulceration. The incidence of peptic ulceration in the general necropsy population was 7.2% whilst in cases with aneurysm it was 22.6%. There was a significant increase in duodenal ulceration in males with abdominal aortic aneurysms. The possible causes for this increased incidence are discussed.

Adolescent

Chemodectoma of the orbit.

The histological and clinical features of a primary chemodectoma arising in the orbit are described. It is suggested that the tumour may have arisen from chemoreceptor tissue in the area of the lacrimal gland.

Aged