STUDIES REGARDING A GLUTAMINE-LIKE SUBSTANCE IN BLOOD AND SPINAL FLUID, INCLUDING A METHOD FOR ITS QUANTITATIVE DETERMINATION.
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Biomedical subjects
Publications and source records attributed to R S Harris.
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Variation in microbial and biochemical components of human four-day plaque was studied in seven subjects who were maintained on a high-sucrose diet during a four-week period. Significant changes in populations of lactobacilli dextranase-producing organisms, Streptococcus mutans, and S sanguis occurred during this period.
The effects of dietary sucrose levels on the microbial composition of 4- and 12-day plaque were investigated in eight dental students. Sucrose-rich diets had no demonstrable effects on total plaque accumulation, whereas total viable microbial density, Streptococcus mutans, and the lactobacilli populations increased. The S sanguis population was unaffected. However, in individual subjects, an inverse relationship between the S sanguis and S mutans population was observed.
The effects of increased and low dietary sucrose levels on the biochemical activities and composition of 4- and 12-day plaque were investigated in eight young men. The subjects were fed supervised, nutritionally adequate diets. Dextran hydrolase, levan hydrolase, and total carbohydrate content were increased during a sucrose-rich diet while invertase activity was decreased. Base-extractable carbohydrate was decreased in four-day plaque during the sucrose-rich diet. Glucosyltransferase and fructosyltransferase activity, buffer-soluble carbohydrate, and buffer-soluble protein were also determined.
The effect of dietary supplementation of glycine at a level of 4% on caries development and the lipid content of rat molar teeth was studied. The glycine supplementation caused a 65.7% reduction in caries development and a 15.1% reduction in lipid content. In a concurrent balance study, it was noted that the dietary glycine did not have any significant effect on the retention of either calcium or phosphorus by the rat's body. Changes in the fatty acid composition of the tooth and a reduction in growth rate were noted, however.