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Biomedical subjects

R S Greco

Publications and source records attributed to R S Greco.

89 records · Page 5Linked to original sources
PubMed1978

Perioperative suppression of the leukocyte migration inhibition assay in patients undergoing elective operations.

The effect of anesthesia and operation on immunity measured by leukocyte migration inhibition using streptokinase-streptodornase is reported in normal patients undergoing elective surgical procedures. Eight-five per cent of the patients exhibited postoperative immunosuppression, and this persisted for 60 days or longer in more than half of them. Despite this, no complication was encountered relating to wound healing or sepsis.

Adolescent↗
PubMed1975

The effect of intact and lysed leukocytes on murine tumor growth and host survival.

The inhibitory effect of sensitized lymph-node cells on transplanted tumor growth in the mouse is well documented. The efficacy of peripheral lymphocytes is disputed. Lysed lymphocyte extracts ("transfer factor"), although effective in transferring several types of delayed hypersensitivity in man, have had equivocal results in animals, particularly in tumor immunity. Fifty 129SV mice were sensitized over 1 month with multiple injections of a transplantable tumor that had arisen in the strain as a spontaneous testicular teratoma. These lymphocyte donor mice were sacrificed and lymphocytes pooled. Half of the lymphocytes were given intact to the 25 mice of experimental group A. Remaining lymphocytes were lysed and given to the 25 mice of group B. The control group C of 25 mice received intact lymphocytes from unsensitized donors. All mice were then challenged with 10(6) tumor cells subcutaneously. Two weeks after challenge no animals in the treated groups (A and B) had palpable tumors, whereas 32% in the control group C had palpable tumors. After 3 weeks 25% of group A, 42% of group B, and 63% of group C had tumors. Tumors ultimately grew in 60% of group A, 76% of group B, and 88% of group C. The effect of treatment on rate of tumor growth after appearance was variable, showing inhibition in some and enhancement in others. The ability of intact, sensitized lymphocytes and lymphocyte extracts to confer relative tumor immunity was demonstrated.

Animals↗
PubMedDate not supplied

Antibiotic bonded nephrostomy catheters for percutaneous nephrostomies.

A prospective controlled trial of the effectiveness of a cefoxitin-bonded nephrostomy catheter was undertaken to determine the effectiveness of an antibiotic bonded catheter in decreasing the infectious complications of percutaneous nephrostomy. The study concludes that bonding of the antibiotic cefoxitin to percutaneous nephrostomy catheters did not influence the incidence of bacteriuria or urinary tract infection. In addition, observations on the overall incidence of complications from percutaneous nephrostomy are made.

Adolescent↗
PubMedDate not supplied

The inverse relationship between microvessel counts and tumor volume in breast cancer.

Angiogenesis has emerged as an indicator of metastatic potential in invasive breast cancer. Exponential tumor growth and the appearance of metastasis are observed as new microvessels form. We postulated that the relevance of angiogenesis would be enhanced if analyzed as a function of tumor volume rather than greatest diameter alone and that microvessel counts would proportionately increase as does volume. Since tumors are three-dimensional solids, volume was calculated using the formula for an ellipsoid, V = pi/6 (a x b x c). Sixty-four tumors < or = 2.5 cm were studied and analyzed in 5 mm incremental ranges. Mean microvessel counts did not vary significantly among these tumor size groups. However, analysis of microvessel counts as a function of tumor volume decreased from 947.1/cm3 (0-0.5 cm) to 18.1/cm3 (2.1-2.5 cm), a greater than 50-fold difference. High microvessel density in small cancers supports the notion of metastasis as an early event, making these small tumors perhaps ideal targets for antiangiogenic agents.

Breast Neoplasms↗
PubMedDate not supplied

Light and electron microscopic studies of an antibiotic bonded vascular graft.

Polytetrafluoroethylene grafts were bonded to oxacillin with the cationic surfactant, benzalkonium chloride. Grafts were placed in the canine aorta and harvested six and twelve weeks after implantation. Light and scanning and transmission electron microscopy were performed in all specimens. No histological differences could be demonstrated between control and antibiotic bonded grafts. Significant antibacterial activity was demonstrated at the time of graft implantation. However, none remained six and twelve weeks later.

Animals↗