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Biomedical subjects

R S Gol'dberg

Publications and source records attributed to R S Gol'dberg.

15 recordsLinked to original sources
PubMed1976

[Role of the endocrine function of the islands of Langerhans in the mechanism of development of hypothalamic obesity].

Administration of alloxan to rats which developed hypothalamic adiposity damaged the pancreatic beta-cells and reduced the insulin secretion, thus arresting further weight gain despite some excess in food ingestion. A conclusion was drawn that in injury of the ventro-medial nuclei of the hypothalamus the most significant mechanism of obesity development was insulin hypersecretion induced by this action.

Alloxan↗
PubMedDate not supplied

[Insulin secretion in rats after hypothalamic damage].

Experiments conducted on female Wistar rats showed that 24 hours after the injury of the ventromedial nuclei of the hypothalamus (VMNH) without animal starvation there occurred a slight reduction of insulin in the islets and a significant elevation of the blood immunoreactive insulin (IRI) level, without any glycemia reduction. In animals with intact VMNH glybenclamide produced no changes in the insulin depot in the pancreatic cells, but somewhat increased the IRI level. However, after the VMNH injury glybenclamide caused a sharp insulin depletion in the islets, and a marked elevation of IRI and a decrease of sugar in the blood.

Animals↗
PubMedDate not supplied

[Changes in insulin secretion shortly after injury of the ventromedial hypothalamus].

In 8 series of the experiments on 95 rats changes in the immunoreactive insulin (IRI) and blood sugar content, as well as of the indices of insulin deposition in pancreatic islands, were studied 5 hours after the injure to the hypothalamic ventromedial nuclei (HVMN) and subsequent two-hour feeding of the animals. It was found that the blood sugar- and IRI levels are significantly lowered in rats 5 hours after HVMN affection, caused by vigorous emotional and motor excitation. The 2-hour feeding of the animals 5 hours after HVMN disturbance led to an increase in the glycemia and insulinemia (almost 5 times) levels.

Animals↗
PubMedDate not supplied

[Effect of fasting on the function of the islands of Langerhans in rats with hypothalamic obesity].

Experiments were conducted on albino rats with hypothalamic adiposity caused by electrolyte damage of the area of the ventro-medial nuclei of the hypothalamus; it was shown that the character of food regimen had a significant effect on the function of the islar apparatus of the pancreas and glucose tolerance. There was a marked increase in functional activity of the beta-cells of the pancreatic islands and disturbed carbohydrate tolerance in the animals kept on food rich in carbohydrates. Prolonged starvation in rats with hypothalamic adiposity decreased the morphometric indices of overstrain in the insulinogenic tissue, and normalized the glycemic curves.

Animals↗