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Biomedical subjects

R S Feldman

Publications and source records attributed to R S Feldman.

At least 37 records · Page 2Linked to original sources
PubMed1990

Age and social competence in preschoolers' decoding of facial expression.

This study examines the relationship between social competence and decoding of emotions in children aged between three and five years. Children were shown videotaped scenarios depicting emotional situations and were asked to choose which of three facial expressions, representing happiness, sadness and fear, would be most appropriate for the character in the situation. Children's level of social competence was assessed by a standardized questionnaire completed by their parents. Results showed that subjects with relatively higher social skills were better decoders than subjects with relatively lower social skills, and that decoding performance improved with age. The results are discussed in terms of the role of non-verbal behavioural skills in general social competence.

Child Development↗
PubMed1988

Arteriovenous malformation of the maxillary sinus: an unusual clinical presentation.

Arteriovenous (AV) malformation is a rare vascular lesion of the jaws with a benign clinical presentation. As a result, AV malformation may be excluded from a presurgical differential diagnosis, with catastrophic results. Review of the pertinent literature showed no documentation of AV malformation in the maxillary sinus, and therefore we present the case of a 43-year-old white man with a history of blunt trauma to the paranasal region, whose differential diagnosis included a vascular lesion.

Adult↗
PubMed1987

Representativeness of the "Ramfjord teeth" for epidemiologic studies of gingivitis and periodontitis.

Data from the Veterans Administration Dental Longitudinal Study of 736 men each examined four times were analyzed to determine how representative the six "Ramfjord Teeth" (RT) were of the rest of the dentition for epidemiologic studies of gingivitis and periodontitis. Correlation coefficients were calculated between scores for gingival inflammation generated by the RT and scores for the teeth in the rest of the mouth; the correlation coefficients between the two scores tended to be high. Sensitivity, specificity and predictive values were calculated for periodontal pathology classified on the basis of the pocket depths of the six RT. Reliance on the RT resulted in systematic underestimation of the prevalence and incidence of deep periodontal pockets. The RT are more than adequately representative of the rest of the dentition for epidemiologic studies of gingivitis, but are inadequate surrogates of the rest of the mouth for epidemiologic studies of periodontitis.

Adult↗
PubMed1986

A comparison between chlordiazepoxide and CL 218,872, a synthetic non-benzodiazepine ligand for benzodiazepine receptors, on serotonin and catecholamine turnover in brain.

Serotonin (5-HT) and catecholamine (CA) turnover rates in midbrain-hindbrain were investigated in rats treated with the benzodiazepine chlordiazepoxide (CDP) or with the anxiolytic triazolopyridazine CL 218,872. A single injection of CDP (2.5-20 mg/kg) decreased 5-HT but not CA turnover rates. Seven daily CDP injections decreased the turnover rates of both 5-HT and CA. In contrast, neither acute nor chronic administration of CL 218,872 (2.5-20 mg/kg) altered baseline turnover rates of 5-HT or CA. Since CL 218,872 has a selective affinity for Type I benzodiazepine receptors, these results suggest that stimulation of Type I receptors is not sufficient to decrease 5-HT or CA turnover rates in midbrain-hindbrain. More importantly, these results question the long-held belief that benzodiazepines exert their anxiolytic and depressant effects through reductions in 5-HT and CA turnover respectively.

5-Hydroxytryptophan↗
PubMed1986

Design and analysis considerations for a longitudinal study of periodontal disease.

Perception and concern for the health changes in our aging population led the Veterans Administration to initiate an interdisciplinary and longitudinal investigation of the aging process, the Veterans Administration Normative Aging Study, in 1963. A cohort of the 2,280 healthy men of this study self-selected to enroll in the dental longitudinal study, an investigation of oral health in these healthy males. In 1968, 1,221 men between the ages of 25 and 75 began with a baseline cycle of 5 general series of examinations, including an interim health history and survey of dietary habits; masticatory performance and taste thresholds; salivary analyses; oral cytologic and radiographic survey and comprehensive clinical data on caries and periodontal status. Design considerations for the Dental Longitudinal Study included prospective planning of specific oral variables to be recorded, and provision of collection techniques to allow for additional analyses based on a wide menu of retrospective data. The volunteer cohort was screened to obtain men who met stringent general health criteria, who represented wide socioeconomic ranges and would likely remain geographically stable. Importantly, enrollment in the parent study was without regard for dental status or oral health. Administrative design considerations included orderly transfer for exam data to machine-readable format by use of optical scan forms designed to register specific oral variables, with security preserved for the primary source records and rapid record retrieval. Additional data collection requiring manual coding was designed to transfer spreadsheets of clinical impressions and diagnoses to computer retrieval protocols. Provisions for recording of exceptional circumstances, i.e., salient oral pathology, were recognized and the optical scan forms modified to index and retrieve such cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

A comparison between chlordiazepoxide and CL 218,872--a synthetic nonbenzodiazepine ligand for benzodiazepine receptors on spontaneous locomotor activity in rats.

Spontaneous locomotor activity was investigated in rats treated with chlordiazepoxide (CDP) or CL 218,872, a synthetic nonbenzodiazepine ligand for benzodiazepine receptors. Acute administration of CDP (2.5 mg/kg) increased activity, whereas a higher dose (10 mg/kg) decreased activity. Acute injection of CL 218,872 (2.5-10 mg/kg) produced a significant dose-dependent suppression of locomotor activity, a finding at variance with a previous report that anxiolytic doses of CL 218,872 are devoid of depressant side effects. Chronic pretreatment with CDP or CL 218,872 (10 mg/kg daily for 6 days) produced a tolerance to the sedative effect of CDP (10 mg/kg), but not to the activity suppressant action of CL 218,872 (10 mg/kg).

Animals↗
PubMed1984

Subarachnoid hemorrhage precipitated by cocaine snorting.

We studied two cases of subarachnoid hemorrhage that occurred within several minutes of "snorting" cocaine. In one case the bleeding was from an anterior communicating artery aneurysm, and in the other case from an arteriovenous malformation in the temporoparietal region. To our knowledge, this hazard of cocaine abuse has not been previously reported.

Administration, Oral↗
PubMed1984

Discriminative stimulus properties of fenfluramine: evidence for serotonergic involvement.

Rats were trained to discriminate 3 mg/kg fenfluramine (FEN) from saline using a milk-reinforced (FR 10 schedule) two-lever operant task. To assess the involvement of the serotonin (5-HT) system in elicitation of the FEN cue, 5-HT compounds were tested for their ability to substitute for or to antagonize the the discriminative stimulus produced by FEN. Following acquisition, the FEN cue was dose-dependent, had a rapid onset (10 min) and a long duration (12 h), and was stereospecific. The putative 5-HT receptor antagonists methysergide and cinanserin antagonized the FEN discriminative stimulus, while chlordiazepoxide, an indirect inhibitor of 5-HT turnover, did not. The FEN cue was also antagonized by the selective 5-HT reuptake inhibitor fluoxetine. Norfenfluramine, p-fluoro-amphetamine, and p-chloroamphetamine, compounds structurally and pharmacologically similar to FEN, substituted for FEN, whereas fluoxetine, cinanserin, methysergide, and chlordiazepoxide did not. The 5-HT precursor 5-hydroxytryptophan partially generalized to the FEN cue. It was further shown that the discriminative stimulus properties of FEN are not based on its anorectic action. These results suggest that the cue properties of FEN might be partially mediated through an interaction with the 5-HT system.

Amphetamine↗
PubMed1983

Effect of high doses of naloxone on shuttle avoidance acquisition in rats.

Administration of high doses of naloxone intraperitoneally (2.5-10.0 mg/kg) resulted in a dose-related impairment of avoidance response acquisition in a shuttle avoidance paradigm in rats. Naloxone in this dose range produced a significant decrease in the number of intertrial responses but did not result in a significant dose-response. Escape latencies were not affected by naloxone administration at any dose tested. The effect of naloxone on activity and nociception are implicated as possible causes of the observed behavior. The results are discussed as behavioral evidence supporting theories postulating multiple opiate receptors.

Animals↗
PubMed1983

Non-steroidal anti-inflammatory drugs in the reduction of human alveolar bone loss.

Aspirin (ASA) and indomethacin are inhibitors of prostaglandin synthesis and reduce bone resorption in tissue culture stimulated by preparations obtained from human gingival tissue. In a retrospective study, we attempted to determine whether ASA or ASA plus indomethacin exert a bone resorption inhibiting effect on human alveolar bone. Dental radiographs of 75 patients with a history of arthritis and long-term ingestion (greater than 5 years) of ASA were compared with dental radiographs of 75 healthy male volunteers from the VA Dental Longitudinal Study (DLS). Proximal bone loss was measured using a Schei Ruler graded on a 10-point scale. The data indicated that the ASA population presented with significantly fewer sites of 10% or greater mesial and distal bone loss than the healthy control population (P less than 0.05). Mean percentage bone loss for the entire dentition was also lower in the ASA group, although the difference was not statistically significant. As there is no evidence to suggest that inhibition of alveolar bone loss is a natural concomitant of the arthritic process, we conclude that the inhibition of bone loss found in this study was due to the chronic ingestion of ASA or ASA and indomethacin.

Adult↗
PubMed1983

Association between smoking different tobacco products and periodontal disease indexes.

Six indexes of periodontal health were recorded in cigarette smokers, pipe/cigar smokers and nonsmokers from the Veterans Administration Dental Longitudinal Study. These indexes included calculus deposition, plaque accumulation, gingival inflammation, periodontal pocket depth, alveolar bone loss and tooth mobility. Cigarette smokers had significantly more calculus deposition than pipe/cigar smokers, although both smoker groups had more calculus than nonsmokers. Cigarette smokers accumulated slightly less plaque than pipe/cigar smokers, and both smoker groups accumulated less plaque than nonsmokers. Gingival inflammation and tooth mobility did not differ between smokers and nonsmokers, nor between the two smoker groups. Cigarette smokers had significantly greater pocket depth than nonsmokers, in contrast to pipe/cigar smokers who were not different from nonsmokers. Radiographic measurements indicated that cigarette smokers had significantly more alveolar bone loss than either pipe/cigar or nonsmokers. After covariance adjustment for age and calculus, all smokers had less plaque, gingival inflammation and tooth mobility than nonsmokers, similar periodontal pocket depth, but only cigarette smokers had greater bone loss. This finding of greater alveolar bone loss in cigarette smokers suggests a tobacco product-related effect in systemic physiologic action.

Adult↗