Phage treatment: can we utilise it for certain infective diseases in India?
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Biomedical subjects
Publications and source records attributed to R S Bhatia.
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Computed tomography in two patients, aged 9 and 14 years, with history of focal seizures, revealed single, small, enhancing CT lesions. These patients were treated with albendazole and anticonvulsants. Follow-up CT scans revealed an increase in the size of the solitary lesions. They were managed conservatively and further follow-up CT scans revealed complete resolution of the lesions. The report suggests that some enlarging CT lesions may also spontaneously resolve. The most likely cause of the enlarging lesions was albendazole therapy.
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India has the largest HIV-infected population in the world with over 4 million infected. The current evidence indicates that the doubling time of the epidemic in India is less than 2 years. Those infected with Mycobacterium tuberculosis add to the gravity of the situation enhancing both morbidity and mortality in these dually infected patients. With the incomprehensive diagnostic facilities available, it is wise to exploit the situation with utilization of tuberculin test with a different cut off criterion for the early diagnosis of mycobacterial infection amongst HIV positive population, especially when there are financial constraints and lack of diagnostic facilities to get CD4 cell count.
An overwhelming majority of disappearing CT lesions in India have been aetiologically linked to cysticercosis. We report 4 patients with disappearing CT lesions in whom the lesion later reappeared at the same (3 patients) or different site (1 patient). One patient was a Taenia carrier. Serial MRI evaluation in one patient revealed a persisting lesion in the interval period. The contribution of these observations towards the understanding of the aetiology of disappearing CT lesions is discussed.
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OBJECTIVE: To compare the cost- and time-effectiveness of 2 methods of placement of vena cava filters for the prevention of pulmonary embolism: the radiologic percutaneous placement of the Vena Tech LGM filter and the surgical cutdown placement of the 24 Fr Greenfield filter. METHODS: Retrospective review of radiologic and clinical records for 15 consecutive patients who had the Vena Tech LGM filter placed radiologically and 15 consecutive patients who had the Greenfield filter placed surgically. Factors studied were cost, procedure time, waiting time and rates of immediate and delayed complications. The follow-up period ranged from 1 to 26 months (mean 7 months). RESULTS: The procedure cost for the radiologic method was $702 less than for the surgical method. The procedure time for the radiologic method was 30 minutes shorter, and the waiting time for placement was also shorter. There was no difference in the complication rates following each procedure. The higher cost of the Greenfield filter accounted for 80% of the total cost difference. CONCLUSION: The radiologic percutaneous method of filter placement is preferred over the surgical cutdown method because of its benefits in terms of cost and time with no increase in risk. However, when the difference in cost between filters is taken into account, there is little difference in overall costs for the 2 methods. Therefore, radiology and surgery departments can place a filter percutaneously at a similar cost. Other factors such as waiting times, complication rates, venography capabilities and physician interest in performing the procedure will dictate which department places the filter.
Esophageal tuberculosis is rare, and its association with intramural pseudodiverticulosis is not widely appreciated. We report a patient with dysphagia who proved to have esophageal narrowing, mediastinal lymphadenopathy, and intramural pseudodiverticulosis. Results of endoscopy and biopsy were nonspecific, but biopsy of the supraclavicular node showed histology consistent with tuberculosis. The patient experienced a dramatic response to antitubercular therapy, with resolution of the esophageal narrowing, mediastinal lymphadenopathy, and esophageal intramural pseudodiverticulosis.
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