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Biomedical subjects

R S Allison

Publications and source records attributed to R S Allison.

At least 37 records · Page 2Linked to original sources
PubMed1992

Carcinoma of the glottic larynx: the Christchurch experience.

AIMS: to establish the local control and survival rates for glottic laryngeal cancer, and to determine the incidence of second primary cancers after treatment of the original tumour. METHODS: a retrospective review of all patients with glottic cancers treated in Christchurch over a five year period, with a minimum follow up of five years. RESULTS: between 1979 and 1984, 83 patients with laryngeal cancer were treated in Christchurch Hospital. Forty-seven of these patients had cancers of the glottic larynx. Overall, 39 of 45 patients were free of their laryngeal cancer at five years (two were lost to follow up). Eight of 45 developed a second primary cancer, usually lung or oesophagus, and this was invariably fatal. CONCLUSION: with multidisciplinary management of head and neck cancers satisfactory control rates can be achieved, but since these patients are usually heavy smokers and drinkers, they are at high risk of developing a second primary cancer. The use of chemopreventative agents is mentioned.

Aged↗
PubMed1991

Patient evaluation of otolaryngology department service at Christchurch Hospital.

One hundred and four consecutive patients seen in the ENT department for consultation and inpatient treatment completed a structured questionnaire at their first postoperative (or posttreatment) outpatient clinic appointment. The aims of the survey were to ascertain the patients opinions and perceptions regarding the ENT department service in a variety of areas. Satisfaction was high in areas of medical and nursing care and with the information given regarding treatment. The major area of dissatisfaction was with waiting times, particularly waiting times at appointments during ENT outpatient clinics.

Adult↗
PubMed1990

Alternating cisplatinum and VAC ineffective in end stage squamous cell carcinoma of the head and neck.

Sixteen patients with end stage squamous cell carcinoma of the head and neck were admitted to a phase II study of alternating courses of cisplatinum (100 mg/m2) and VAC (vincristine 1.4 mg/m2, adriamycin 50 mg/m2, cyclophosphamide 750 mg/m2) given at three weekly intervals. Only two patients achieved a response (12 per cent). The median survival time was 62 days which is much the same as that of a similar group of patients who received no chemotherapy in a previous trial (70 days).

Aged↗
PubMed1989

Aspiration cytology in the diagnosis of head and neck masses: the early Christchurch experience.

Fine needle aspiration cytology has been performed on patients presenting with head and neck masses in Christchurch since mid-1985. The results of an initial 120 aspirations were reviewed. Histology was available to compare with the cytology result in 58% of cases. Clinical review was used to assess the accuracy of the cytology result in the remaining cases. The majority of the masses aspirated were of benign origin (72%). The cytological diagnosis was accurate in 79% of cases. Of the remaining aspirates, 13% were inaccurate and 8% nondiagnostic. The sensitivity for malignant lesions was 100%, with 86% specificity (for benign lesions). Particular diagnostic difficulty was found in the differentiation between some salivary gland tumours, and the assessment of aspirates from neck masses after combined therapy (radiotherapy and surgery). Fine needle aspiration cytology is of considerable value in the management of head and neck masses.

Adolescent↗
PubMed1989

Lateral cervical cysts: a review of 42 cases.

A review of forty-two patients presenting over a ten year period with a histological diagnosis of lateral cervical (branchial) cyst was undertaken. Most occurred in the second and third decades (29/42), there was a slight female predominance (29/42). Thirty-five lesions presented at the classic site, 7 presented elsewhere in the neck. Ten lesions were painful on presentation, none of these were associated with systemic signs of infection. Preoperative diagnosis was correct in only 22 cases and was more likely to be incorrect when on presentation the lesion was painful, located away from the classic site or was solid to palpation. Incision of painful cysts led to increased patient morbidity. It is suggested that greater awareness of less usual presentations of lateral cervical cysts and use of fine-needle aspiration biopsy would improve diagnostic accuracy and reduce morbidity.

Adolescent↗
PubMed1989

Parapharyngeal tumours: a review of 23 cases.

The anatomy of the parapharyngeal space is described and experience with 23 patients with parapharyngeal tumours seen over a 10-year period is reported. Despite reaching a large size, these tumours may be relatively asymptomatic, or be discovered incidently. CT scan, MRI, arteriography and fine needle aspiration are useful in establishing a diagnosis. The most common histological type (13/23 patients) was pleomorphic adenoma and these tumours were managed by transoral removal if small, or a combined transoral-external approach if large. No patient required a mandibulotomy for access and no benign tumour recurred. The outcome was poor in the 5 patients with malignant tumours and a more radical approach, midline mandibulotomy, should be considered if malignancy is suspected.

Adenoma, Pleomorphic↗
PubMed1986

The pectoralis major muscle in head and neck reconstruction.

From June 1980 to June 1985 51 pectoralis major muscle flaps have been used for one-stage reconstruction of extensive defects in the head and neck following cancer surgery. The pectoralis major muscle was used as a myocutaneous flap on 28 occasions, as a muscle covered with split thickness skin on 17 occasions, and as a muscle-only flap six times. The muscle, in its various forms, was used for reconstruction of the pharyngooesophageal segment, the tongue, floor of the mouth and oropharynx, to replace the skin of the face and neck, and to provide a well vascularized recipient bed for a split-rib graft, used to replace a defect of the anterior arch of the mandible. Many of the problems associated with the use of a pectoralis major myocutaneous flap can be avoided by the judicious use of a muscle flap on its own or covered by a split thickness skin graft.

Aged↗
PubMed1985

Bromhexine in the treatment of otitis media with effusion.

In a double blind randomised trial of 95 children aged 3-8 years with otitis media with effusion (OME), the efficacy of the mucolytic agent bromhexine hydrochloride (Bisolvon) was compared with a placebo. Each child received two 4 week courses of either bromhexine or placebo in a random fashion. One hundred and ninety ears were available for analysis, i.e. 380 'ear treatments'. There were 198 ears in the placebo group and 182 ears in the bromhexine group. The resolution rate in the placebo treated group was 19% and in the bromhexine treated group 16%. Bromhexine does not appear to be a useful drug for the treatment of OME in children.

Bromhexine↗
PubMed1983

Pulmonary sequestration: a review of 12 cases.

A review of patients over a twenty-three year period with a diagnosis of pulmonary sequestration was undertaken. Of the twelve patients with this diagnosis, ten had intralobar sequestrations, and two had the extralobar variety. The most common presenting complaint, in six of the patients, was an unresolving localised chest infection. All had abnormal plain chest radiographs. There was a high incidence of an anomalous vascular supply, and aortography was useful in investigation. Operative management consisted of segmentectomy or lobectomy for the intralobar form and simple excision for the extralobar form with good results.

Abnormalities, Multiple↗