Search PubMed⌕ Search

Biomedical subjects

R Rutowski

Publications and source records attributed to R Rutowski.

At least 19 recordsLinked to original sources
PubMed2005

Epidermal growth factor receptor (EGF-R) in Dupuytren's disease.

The aim of this paper was to examine participation of the epidermal growth factor receptor (EGF-R) signal pathway in the pathogenesis of Dupuytren's disease. The study showed changes in the ratio of membrane EGF-R to its intracellular level during the different clinical stages of Dupuytren's contracture progression. Our observations of a high ratio of surface to intracellular EGF-R in the palmar aponeurosis of patients with second degree of Dupuytren's disease (Iselin's classification), which was significantly higher than this ratio in control palmar fascia (P=0.022), would suggest that EGF-R has a role in the involutional phase of the disease.

Aged↗
PubMed2000

[Allergy to nickel, chromium and cobalt after osteosynthesis].

Metals are known as a common cause of contact allergies. The prevalence of sensitisation to the composite metals makes for a potential risk of osteosynthesis complications in patients suffering from long bones fractures. In the study the prevalence of delayed allergy to nickel sulphate, potassium dichromate and cobalt was estimated as well as the relation to the osteosynthesis complications. The atopy prevalence was estimated too. Persons under examination were divided into 3 groups. I--treated with osteosynthesis without complications (n = 20), II--treated with osteosynthesis with synostosis complications (n = 16) and III--negative controls (n = 34). We estimated 5% prevalence of delayed allergy to nickel in group I, 6.25% in group II and 5.8% in group III. In patients exposed to chromium we observed delayed allergy prevalence of 5.8% in group I and 3% in group III. No allergy to chromium in group II was revealed. No allergy to cobalt in all groups was revealed. The prevalence of atopy in group II was rare (6.35%) when in group I it was 45% and in controls 32%. The more frequent occurrence of type IV allergy to metals in atopic patients was not confirmed. There was no difference between the prevalence of delayed allergy to metals in groups I and II. Only one case of secondary allergy to chromium was observed.

Adolescent↗
PubMed2000

[Experimental research on the usefulness of the Dallos polyester prostheses in reconstructive operations of knee joint ligaments].

Usage of allogenic grafts in surgery of severe injuries of knee joint may be necessary in spite of their disadvantages. Prosthesis Dallos made by Tricomed in Lódź has been tested taking into account its usage in reconstruction of knee sacral ligaments. Prosthesis was implanted into 7 piglets in place of the removed front sacral ligament. In the tests the mechanical requirements made for this kind of grafts were confirmed. However, an unfavourable influence of this prosthesis on the synovial membrane of a joint and weak overgrowth of the graft with connective tissue, which can be eliminated by usage of looser knitting, were noticed.

Animals↗
PubMed2000

[Testing the usefulness of a provisional polyester prosthesis for augmentation in reconstructive operations of knee joint ligaments].

Prosthesis from polyester fibres 5 mm wide with loose knitting finished on both ends with teflon handles for fixing bones with a wholly aphid screw made by Tricomed company in Lódź according to its own idea was the subject of the test. The tests were made on 7 piglets. The prosthesis together with an autogenic graft taken from the middle third of a patella ligaments was implanted into the place of the excised front sacral ligament. The implanted prosthesis was characterised with a high biocompatibility, satisfying mechanical resistance and easiness of fixing of the tested graft. We noticed clinically and pertaining to autopsy the possibility of removing the allogenic graft after achieving the full healing of the autogenic graft without the possibility of hurting that last one.

Animals↗
PubMed1997

[Testing tissue reactivity to surgical sutures using a personal point method].

In the Institution of Experimental and Biomaterial Research Surgery of Medical Academy in Wrocław works on biological methods of estimation of different biomaterials including, first of all, surgical threads have been carried out for 30 years. The purpose of this work is to define the local biological reaction on the implanted absorptive and non-absorptive surgical threads. The present estimation of reactivity of surgical threads depended on a description of a great number of histological samples and on observation of numerous microscopic fields for each tested thread. It required long and tiring descriptions the analysis of which was made difficult and often led to non-objective conclusions. The presented punctual system depends on observation of the field of vision in a biological microscope which includes transverse cross-section of the implanted thread together with the surrounding tissues. The estimation of the histological samples in magnification of 45 times allows to define the range of infiltration of tissues with inflammatory cells in comparison with the diameter of the implanted thread. Observations in magnification 120 times allow to differentiate cells included in non-specific inflammatory process. The worked put punctual system enables to define the level of tissue reaction on the basis of uniform criteria.

Animals↗
PubMed1993

Neurotizations by means of the cervical plexus in over 100 patients with from one to five root avulsions of the brachial plexus.

In the years 1982-1991, we treated over 100 patients with avulsion of from one to five roots in perinatal (n = 21) and traumatic (n = 81) lesions of the brachial plexus. Based on the clinical diagnosis and the surgical findings, we divided all operated patients into four groups: 1) avulsion of all roots or avulsions and disruption of the rest of the brachial plexus; 2) avulsion and disruption of one to four roots and preservation of some elements of the brachial plexus with fibrotic changes; 3) avulsion and disruption of one to three roots, with some elements showing no macroscopic changes; and 4) children with perinatal brachial plexus palsy. In cases of root avulsion, we performed neurotization from the cervical plexus, the accessory and intercostal nerves. In patients with one to three root avulsions, we have performed selective neurotization for 3 years. The best results were obtained in groups 3 and 4, but some improvement was also noted in the other groups.

Adolescent↗
PubMed1992

[Attempts at modification of the polyester vascular prosthesis].

Polyester vascular bilaterally velour prostheses produced by the Enterprise of Medical Products TRICOMED in Lodz were modified through: putting negative electric charge on the internal surfaces of prostheses; additional cleaning with ethanol; covering of the surfaces of prostheses with silicone preparation; two-sided covering of the surfaces of prostheses with collagen by the radiative method; covering of the surfaces of prostheses with chitosane. Laboratory investigations, investigations of hemolytic and toxic effects of aqueous as well as experimental investigations has been carried on piglets. During these investigations it was observed that the carried preparations caused multiple increase of electrical conductivity of proper and dry remnant after evaporation of the aqueous extracts. Hemolytic and toxic effects were not observed. In radiological and pathomorphological investigations it was observed that none of the preparations used for modification of vascular prostheses influenced improvement of their biological properties. In comparison with the initial prostheses DALLONR these prostheses evoked a greater reaction of tissues which was manifested with a thick internal layer causing narrowing of the lumen of the section with prosthesis or closing it. A small improvement of the biological properties of the prostheses were achieved after cleaning them with methanol. However, this improvement is so small that it does not justify changes in the existing technology.

Animals↗
PubMed1992

[Absorption of chitosan applied to polyester discs in rats after implantation].

Experiments have been made on white rats implanting polyester blocks covered with chitosan into the peritoneal cavity and to the abdominal wall skin. Before implantation the material was sterilized with ethylene oxide or radiation. The animals were subjected to autopsy 3, 7, 14, 21, 25, 30, 35, 40, 45, 50, 55 and 60 days after implantation with macroscopic and microscopic evaluation. On the basis of the carried out experiments it was stated that the disintegration of chitosan proceeded not uniformly. The resorption time of chitosan oscillated in the range of 45-60 days and it was accompanied by rather strong specific inflammation process. It was characterized with fibrin effusion and with appearance of multi-flapped neutrocytes. Essential distinctions in the resorption process of depending on the sterilization mean of the blocks as well as on the place of implantation were not stated.

Abdominal Muscles↗
PubMed1987

[Biocorundum--a new/type of poreless ceramic material of aluminum oxide for the manufacture of the elements of hip joint prosthesis. Biological and technological studies].

The Institute of Refractories Materials in Gliwice undertook researches in the field of technology of a new ceramic material of aluminium oxide for production of coxal joint endoprostheses. A poreless ceramic material of high chemical purity and density and required microstructure and good resistance to fracture, was achieved. The new ceramic material was called Biocorundum. By means of a similar technology also series of samples were produced for testing the biocompatibility of the material. Biological studies were carried out in the Department of Experimental Surgery and Biomaterials Research, Chair of Traumatologic Surgery, Medical Academy of Wroclaw. The studies comprised: 1. laboratory and toxicological tests in vitro of water extracts, 2. pathomorphological studies after intramuscular, peritoneal and intra-bone implantation of samples of the material in rats and piglets, 3. ultrastructural scanning studies of the implantation in rats and pigs and after 3- and 6-months long keeping in the Ringer solution. Preliminary studies and biological studies in vitro have shown a complete conformity of the material with the requirements. Tissue reactivity was studied on 36 Wistar rats. By pathomorphological studies a systematic macroscopic and microscopic estimation was possible. They have shown only minimal tissue reactivity to biocorundum implantation. In experimental studies on 14 piglets the biocorundum grafts were implanted into the tibia epiphysis for 3- and 6-months. Clinical, pathomorphological and X-ray studies were carried out. In all cases the Biocorundum grafts healed without any complications. On the basis of pathomorphological studies, the tissue reactivity around the grafts were estimated as minimal. This shows a high biocompatibility of the ceramic material. In X-ray studies were observed around the grafts small osteosclerotic changes and periosteum stratification. These changes resulted after surgical interventions in quickly growing piglets. Complementary studies of the surface of the material by scanning microscopy after 3 months long implantation and after 3 months long contact with the Ringer solution did not show any changes in comparison with the surface of the initial samples. After 6 months long implantation in individual samples rounding of the ceramic material grain edges were found, which could result from biological corrosive power. This agree with the findings of other studies on other ceramic aluminium oxide materials. The achieved results of complex studies of biocompatibility of the new poreless material developed in Poland--Biocorundum--have shown its complete biological suitability for production of elements of osteoarticul

Aluminum↗
PubMed1982

Radiosterilized polyester knitted nets Dallop.

Polish surgical polyester knitted nets Dallop sterilized by radiation were implanted and tested on Wistar rats. The results of the experimental evaluation are positive and lead to the conclusion that the Dallop radiosterilized polyester nets may be used in humans. The evaluated knittings fulfill the most up-to-date biological requirements and may be utilized as implantation material for plastic and reconstructive surgery.

Abdomen↗