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Biomedical subjects

R Russo

Publications and source records attributed to R Russo.

At least 397 records · Page 22Linked to original sources
PubMedDate not supplied

[Study of the DNCB skin test in patients with solid neoplasms].

The DNCB skin test was carried out on 47 patients with solid tumours. Fifteen deaths were noted among subject displaying a negative response and in 1/24 positives. A statistically significant relation was found between negativity and several blood chemistry parameters: increased IgG, positive PCR, inversion of the A/G ratio and the fall in peripheral lymphocytes. The method employed for the test is described.

Dinitrochlorobenzene↗
PubMedDate not supplied

Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer.

BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0 degrees C and 12 mins at 37 degrees C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.

Aged↗
PubMedDate not supplied

[Cervicofacial neuroendocrine Merkel cell carcinoma: radiotherapy].

The Authors report a case of Merkel cell carcinoma of the cervicofacial district, particular due to its clinical and evolutive characteristics. The Merkel cell carcinoma was first identified by Toker in 1972 and is also known as a primary neuroendocrine the or trabecular carcinoma of the skin. The Merkel cell carcinoma is a rare aggressive skin cancer most frequently localized in the cervicofacial district. Although in earlier reports on the clinical history of these tumors primary emphasis was placed on their local aggressive behaviour, it has recently become evident that these neoplasms have a marked propensity for early dissemination. Distant metastases are often responsible for disease-related mortality. Merkel cell carcinoma have classically been managed with surgery alone or surgery followed by radiation therapy. Treatment of Merkel cell carcinoma with radiation therapy alone has usually been reserved for advanced unresectable tumors.

Adenocarcinoma↗
PubMedDate not supplied

Laparoscopic liver tumour resection with the argon beam.

Our initial experience with four minor resections for one malignant and three benign lesions is reported. Dissection was accomplished by mechanical fragmentation and hydrojet. Coagulation was effectively achieved by the argon beam system. Larger vessels were clipped. Three patients were treated laparoscopically and were rapidly discharged after an uneventful postoperative course. The other patient (small hepatocellular carcinoma in cirrhotic liver) had an intraoperative cardiac arrest, probably due to gas embolism. After restoration of normal cardiac activity, the operation was completed after conversion to an open approach. When using the argon coagulator it is necessary to prevent excessive intra-abdominal pressure due to the flow of argon gas and to avoid injury to the hepatic veins, which may cause gas embolism.

Adenoma, Liver Cell↗
PubMedDate not supplied

[Stress myocardial scintigraphy in the pre- and postoperative diagnosis of ischemic cardiopathy. The correlations between the clinical aspects and the coronary angiographic picture].

With radioisotopes it is possible to study the heart obtaining complementary or substitutive informations to those provided by the most common noninvasive methods of myocardial assessment and by coronarography. This paper aim is to report experience with thallium 201 and 99mTc isonitrile in the diagnosis and followup of ischemic heart disease, in particular correlating clinical, coronarographic and scintigraphic findings. MATERIAL AND METHODS. During the biennium 1989-91 we have used the myocardial perfusion imaging with thallium 201 in 29 patients (20 male age ranging from 40 to 60 years) injecting 2 mCi at exercise peak with immediate planar mapping, followed by a second registration at rest 4 hours later (thallium 201). Imaging with 99mTc SESTAMIBI has been carried out in 6 patients (two of whom previously studied with thallium 201) injecting 20-22 mCi both at stress peak and at rest, with SPECT mapping 60'-90' later. All these patients presented specific problems for the diagnosis of myocardial ischemia. The exercise testing has been performed by a bicycle ergometer and with a standardized procedure increasing every two minutes the workload to the maximum tolerated according to the clinical conditions and to the response. All antianginal treatments were discontinued for at least 48 hours before testing and the patients were fasted for 6 hours. The images were obtained using a small field scintillation camera with a low-energy general purpose collimator. We divided the patients in 4 groups: Group A. Six patients who had an open heart operation: in 5 coronary revascularization was carried out (plus left ventricular aneurysmectomy in one and plus aortic valve replacement in another); in 1 patient an aortic valve replacement was performed on. Group B. Six patients have been evaluated after coronary angiography. Group C. Seventeen patients with doubtful diagnosis of myocardial ischemia on the base of the symptoms and/or non invasive testing as rest or stress electrocardiogram (ECG). Group D. In 6 more patients (2 of those previously studied with thallium 201) the myocardium has been assessed with SESTAMIBI. RESULTS. In one patient of the group A the thallium 201 images detected silent ischemia; in 5 removed the diagnostic doubts of the ECG findings owing to left ventricular overload or to old infarctions in 2 patients and to electrolytes disturbances or pharmacological effects in 3 patients. In group B patients the thallium 201 further on could assess the extent of ischemic and necrotic areas suggesting the final indications to angioplasty in 3 patients, medical treatment in 2 and surgery in 1. We could not find correlations between the extent of the disease predicted by the coronarography and the findings of the thallium 201 images. In the diagnosis of myocardial ischemia, group C, the Thallium 201 has been very useful and specific excluding an ischemic origin in 4 patients with arrhythmias, in 2 patients without symptoms of angina but with doubts at rest and exercise ECG findings and in 4 with atypical thoracoalgia and doubtful ECG. On the contrary, this test could give the final diagnosis of ischemia in 6 patients displaying its sensitivity in detecting coronary artery disease. Among the patients assessed with SESTAMIBI, in 2 this test has been essential in evaluating the myocardial contractility and the segmental wall motion. DISCUSSION. The usefulness of Thallium 201 imaging, as a very sensitive mean in detecting coronary artery disease and in the assessment of myocardial viability, is well known. Although the most common indications of this technique are well standardized, in the clinical practice there are many situations in which the thallium 201 can contribute to the diagnosis and to the management. (ABSTRACT TRUNCATED)

Adult↗
PubMedDate not supplied

[Comparison of urokinase and tissue-type plasminogen activator in transcatheter arterial fibrinolysis].

The transcatheter injection of fibrinolytic agents is now the treatment of choice of the acute occlusions of the peripheral arteries. We retrospectively compared the efficacy and safety of two fibrinolytic agents (urokinase and recombinant tissue-type plasminogen activator) in 83 consecutive patients: 37 with occlusion of surgical bypass grafts, 36 with occlusion of atheromatous vessels, 5 with post-angioplasty occlusion, 2 with post-traumatic thrombosis, 2 with cardiogenic emboli and 1 with thrombophilia. Recanalization was achieved in 55 of 59 (93%) patients treated with urokinase and in 21 of 24 (88%) patients treated with recombinant tissue-type plasminogen activator (p > 0.05). The latter provided a more rapid recanalization than urokinase but was also responsible for the complications observed in all 10 (12%) patients. These results indicate that urokinase is to be preferred to recombinant tissue type plasminogen activator for routine arterial transcatheter fibrinolysis.

Adult↗
PubMedDate not supplied

[Onset time and duration of action of neuromuscular block induced by increasing doses of vecuronium bromide].

The authors determined the onset time and the duration of action of neuromuscular blockade by a 100-150 micrograms.kg-1 vecuronium random administration in 30 ASA I and ASA II patients during urological surgery. Neuromuscular blockade was evaluated by the electromyographic response to stimulation of the ulnar nerve train of four. The time from vecuronium administration to complete abolition of twitch response (T1 = 0%) did not change significantly, in spite of 50% increased dose of neuromuscular relaxant. The duration of action of neuromuscular blockade, that is the time from T1 = 0% to T1 = 25%, increased from 38.2 +/- 7.5 min to 52.5 +/- 19.8 min by the increasing of neuromuscular relaxant dose (p < or = 0.018). Vecuronium increased doses did not shorten significantly the onset time.

Adult↗
PubMedDate not supplied

[The magnetic resonance and histological correlations in hepatocellular carcinoma].

Hepatocellular carcinoma (HCC) exhibits variable features on Magnetic Resonance (MR) images. In this study, the correlations between MR patterns of HCC and histopathologic findings are investigated. Fifty patients with HCCs were studied with MR at 0.5 T. All neoplastic lesions were subsequently submitted to biopsy: structural pattern, tumor grading (following the Edmonson and Steiner classification), the presence of fatty degeneration, and intracellular glycogenic content (established on the basis of staining by the periodic acid Schiff-PAS-method) were evaluated. Thirteen HCCs were < 3 cm, 16 ranged 3-5 cm, and 21 were > 5 cm. On spin echo (SE) T1-weighted images (T1w), 18 tumors were hyperintense, 10 isointense, and 22 hypointense with respect to the surrounding liver parenchyma. On SE T2-weighted images (T2w), 46 HCCs resulted hyperintense and 4 isointense. Histopathologic examination demonstrated 46 tumors with trabecular pattern and 4 tumors with pseudoglandular pattern; however, no significant correlation between structural pattern and signal intensity was observed. Thirty-one HCCs were classified as well-differentiated tumors (grade 1), 12 as moderately differentiated tumors (grade 2), and 7 as poorly-differentiated tumors (grade 3). Hyperintensity on SE T1w and isointensity on SE T2w significantly correlated with grade 1 tumors (p < 0.01). No MR feature demonstrated significant correlation with grade 2 or grade 3 tumors. Fatty degeneration was demonstrated in 4 HCCs: none of them resulted hyperintense on SE T1w (2 were isointense and 2 hypointense). PAS staining was strongly positive in 16 lesions, slightly positive in 20 and negative in 14 lesions. Strong positive staining by the PAS method significantly correlated with hyperintensity on SE T1w (p < 0.01). Hyperintensity on SE T1w and isointensity on SE T2w strongly suggest well-differentiated HCCs. High signal intensity on SE T1w correlates with high glycogenic content of the tumor cells and seems unaffected by the presence of fatty degeneration.

Aged↗
PubMedDate not supplied

Fine needle aspiration cytology of lipid-secreting breast carcinoma. A case report.

Lipid-secreting carcinoma is a rare type of invasive carcinoma of the breast first described by Aboumrad et al in 1963. We believe lipid-secreting carcinoma to be a specific type of breast carcinoma and that it has to be differentiated from invasive lobular carcinoma. We report for the first time the fine needle aspiration cytologic features along with the histologic and electron microscopic findings.

Biopsy, Needle↗
PubMedDate not supplied

[Prevalence of urinary infections caused by GBS in diabetic patients].

On a randomized sample of 305 diabetic patients and of 479 controls was studied for an epidemiological research about the colonization of urinary tract by Group B-Streptococci (GBS). The detection rate was 16.44% in the diabetics, and 8.77% in the controls. and it was higher in diabetic women than diabetic men (R.P. 1.96, p < 0.05). The age, the model of diabetes treatment, and the metabolic control of diabetic people didn't be significatively correlated with GBS presence. Most of GBS that have been identified in diabetic patients were belonged to the sierotype I, whereas in the controls were belonged to the sierotype III.

Animals↗