Biomedical subjects
R Ruggia
Publications and source records attributed to R Ruggia.
[New diagnostic directions in liver disease. The value of studying "parallel enzyme constellations"].
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[Abdominal complications of the ventriculo peritoneal derivations].
Thirty-nine ventriculo-peritoneal shunts in children have been analyzed since 1962 to 1976 at the Neurological Institute in Montevideo. In these cases there were 8 important abdominal complications (20%): 7 were associated with ventriculitis, all with infiltration or fistula on the trajet, 3 cases were operated on because of intestinal occlusion, 1 of them with perforative acute peritonitis. In the others, gastric distention, abdominal distention, and transient ileus were found. Five patients died, 4 of them with ventriculitis, 3 children who had suffered ventriculitis, survived. They overcame their hydrocephalus by means of ventriculo-atrial shunts, afterwards their infection was cured. From the result of the test of these cases it is gathered in view of a ventriculo-peritoneal shunt disfunction, that it is necessary to: 1) As far as possible rule out ventriculitis. 2) In cases in which ventriculitis should be proved to exist and with a peritoneal reject, after the infection has been cured, one should not insist with the ventriculo-peritoneal diversion, because in this case the possibility of the relapse taking into account the abdominal intolerance, increases. After the ventriculitis should be got over with a proper bacteriological control, a ventriculo-atrial shunt must be performed. 3) The changing of the form of the divertion system is considered immediately after an abdominal aseptic intolerance is present (ileus, ascites, etc.), due to the double risk of intestinal occlusion or ventriculitis.
Ganglionic blocking action of some methylpiperidines.
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[Hepatolenticular degeneration. Wilson's disease. New case contribution].
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[Selective adsorption of homocysteine using HFR-on line technique].
Homocysteine (Hcy) is grossly elevated in hemodialysis (HD) patients. Treatment with folic acid and/or vitamin B12 fails to normalize Hcy levels in the majority of patients. Treatment with various dialyzers with different flux characteristics has produced contrasting results. Hemodiafiltration reinfusion (HFR) on-line (double chamber hemodiafiltration (HDF) with regenerated ultrafiltrate reinfusion) is a novel method combining the processes of diffusion, convection and absorbance. The ultrafiltrate is regenerated through a charcoal-resin device. Our aim was to observe the effect of the HFR on-line technique on removing Hcy. We investigated the effect of this treatment on Hcy levels in 10 patients with a mean Hcy level of 57.6 micromol/L (range 24.1-119.7). We measured Hcy, folate and vitamin B12 pre- and post-dialysis and in the ultrafiltrate pre- and post-cartridge at 10, 120 and 240 min. Mean Hcy levels were 57.6 and 35.3 micromol/L (range 9.9-80.3) (p=0.005) pre- and post-dialysis, respectively, while folate and vitamin B12 were unchanged. Pre- and post-cartridge Hcy levels were 11.6 vs 2.5 (p=0.005), 9.3 vs 3.9 (p=0.005), 7.7 vs 4.6 micromol/L (p=0.012) at three time points considered, while folate and vitamin B12 were essentially undetectable. These preliminary data, which need confirmation in a long-term study, seem to indicate that HFR on-line reduces Hcy levels, not only through a possible reduction in uremic toxins, but also through the actual removal of Hcy by absorbance on the charcoal-resin cartridge.