Search PubMed⌕ Search

Biomedical subjects

R Rudolph

Publications and source records attributed to R Rudolph.

311 records · Page 18Linked to original sources
PubMedDate not supplied

Semi-depot hyposensitization in severe hay fever: its clinical effectiveness and the therapeutic problems. (A four year study using intranasal challenge testing to monitor success).

Hyposensitization treatment for at least two years using pyridine-extracted alum precipitated (PEAP) extracts was carried out on 332 cases of severe hay fever, some of which were steroid dependent. Subjective self-assessment and weekly average use of additional medication were recorded, nasal challenge tests were conducted before and during treatment and related to the clinical picture. Successful treatment was unrelated to age, though distinctly limited where there was a history of more 15 years illness. It was however related to the pollen count from 1973 to 1976 and to the type and number of the antigens to which there was a clinical response. In spite of specific hyposensitization 4,2% of the pollinosis cases developed additional pollen asthma. In the course of treatment there were several instances of an enlargement of the individual antigen spectrum; sensitization to pollen, mould fungi, house dust and animal epithelia were recorded. In a total of 11,850 injections there were severe local reactions in 16,2% rhinoconjunctivitis in 1,6% asthma in 0,4% and urticaria in 0,4%. One female patient went into anaphylactic shock 12 hours after the administration of the antigen extract. In about 20% of the injections granulomas developed, about the size of a cherry-stone, which persisted for up to six months and which in some instances were reactivated by severe exposure to allergens. There was an unusually high percentage of organ and generalised reactions whenever the treatment was continued using a new antigen solution without reducing the dose.

Administration, Intranasal↗
PubMedDate not supplied

The effect of molecular chaperones on in vivo and in vitro folding processes.

Numerous successful experiments of in vitro protein folding demonstrate that all information required for the formation of the native, three-dimensional structure of a protein is encoded in the amino acid sequence. Thus, in vivo folding was long considered an autonomous process unaffected by other proteins or cellular components. This central paradigm of in vivo protein structure formation was abandoned with the identification of molecular chaperones which facilitate protein folding both in vitro and in vivo. Recently, mechanistic details of chaperone action have been analyzed at a molecular level. Members of the molecular chaperone families seem to fulfil different tasks along the folding pathway. Understanding the mechanism of the chaperone machinery will help to design efficient folding processes for the in vitro folding of misfolded recombinant proteins. Furthermore, cellular fine-tuning of the chaperone machinery may provide new tools for the prevention of misfolding of recombinant proteins.

Heat-Shock Proteins↗
PubMedDate not supplied

New trends in skin tumor surgery.

Over 8 years, 1700 patients were referred from the Mohs' Surgery and Cutaneous Laser Unit after Mohs micrographic skin tumor excision to the Division of Plastic and Reconstructive Surgery. Preoperative coordination between the two divisions was emphasised in wound preparation and timing of reconstruction for maximized patient convenience and outcome. Most repairs of facial and extremity defects were carried out under local anesthesia. Techniques of repair were selected based upon algorithmic priorities emphasizing simple techniques over complex ones. Direct closure, skin grafts and flaps were used. Preference for aesthetic subunit reconstruction of the face and the use of particular flap techniques including the O-to-S, O-to-T, V-to-Y island advancement, islandized nasolabial flap for alar reconstruction and the forehead flap for nasal dorsum and tip repair are illustrated.

Basal Cell Carcinoma↗