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Biomedical subjects

R Rozzini

Publications and source records attributed to R Rozzini.

81 records · Page 5Linked to original sources
PubMed1983

Effect of suloctidil on dopaminergic transmission in various rat brain areas: possible uses as drug for the elderly.

Suloctidil is a drug used in the elderly endowed with a mechanism of action at neuronal level which has not been completely explored. The results of the present study indicate that acute treatment with suloctidil induces a decrease of serum prolactin levels and a decrease of 3,4-diidroxyphenylacetic acid concentrations in various rat brain areas. In addition, the repeated injection of small Suloctidil doses produces a down-regulation of dopaminergic receptors. These data suggest that Suloctidil has dopamino-mimetic properties in vivo. This pharmacological activity may be of importance in the clinical action of Suloctidil in the elderly.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1982

Effect of right middle cerebral artery occlusion on striatal dopaminergic function.

Following right middle cerebral artery occlusion in the rat, striatal dopaminergic system alterations were studied. Dopamine turnover was assessed by measuring 3,4-dihydroxyphenylacetic acid concentrations and dopamine receptor function, by measuring (3H)-Spiroperidol binding. There was a transient decrease in 3,4-dihydroxyphenylacetic acid and permanent damage to dopamine receptors, as indicated by a time-dependent progressive reduction in the number of (3H)-Spiroperidol binding sites. The receptor deficit also manifested as turning behaviour towards the lesioned side 4 weeks after the lesion following subcutaneous apomorphine. Long-term changes of dopaminergic receptor activity in this experimental model of cerebral infarction may be secondary to cortical degeneration following middle cerebral artery occlusion.

3,4-Dihydroxyphenylacetic Acid↗
PubMedDate not supplied

Risk factors for the development of pressure sores in hospitalized elderly patients: results of a prospective study.

Pressure sores are a serious and still common complication of immobility in the elderly. Despite the potential seriousness of the problem, factors that identify bedridden patients at the greatest risk for pressure sores have not been well characterized and the epidemiology is not yet well defined. The characteristics of 56 subjects with pressure sores and 92 at risk (confined to bed or chair for at least 1 week) were first compared in a cross-sectional analysis; subjects at risk were then followed up for 2 months to identify factors that may contribute to the appearance of pressure sores during hospitalization. In hospitalized patients at risk we found an incidence of 22.8% within 60 days. Our data suggest that age is not a risk factor for the development of pressure sores, while urinary incontinence, fecal incontinence, altered consciousness, impairment of cognitive function, poor functional status, time spent in bed, lack of caregivers and poor nutritional status are important factors associated with pressure sores in hospitalized elderly patients.

Journal Article↗
PubMedDate not supplied

Assessment of alcohol consumption and alcoholism in the elderly.

This study evaluates characteristics associated with alcohol consumption or alcohol-related problems in an elderly population, as detected by CAGE questionnaire and self-reported alcohol intake respectively. Data were obtained from a multidimensional study carried out in a community-dwelling population aged 70-75 (n = 1205, 389 males and 816 females) living in the city center of Brescia, in northern Italy. All information was gathered by self-report. Male gender, better mood, daily function, somatic health, not living alone, and being married were significantly associated with self-reported alcohol consumption. Male gender, poorer cognitive function, and income dissatisfaction were significantly associated with alcohol problems as detected by CAGE. Data suggest that self-report of alcohol intake, though intrinsically loaded with imperfect internal consistency, does not necessarily indicate risk of alcoholism; on the contrary, it can reveal the positive psychological attitude of the drinking habit. CAGE questionnaire, which is sensitive to alcohol related problems, is associated with poor psychosocial conditions.

Aged↗
PubMedDate not supplied

Serum cholesterol levels as a measure of frailty in elderly patients.

The authors evaluated the association between serum cholesterol levels and social, clinical, and functional characteristics in 637 elderly hospitalized patients (mean age = 79.1 years, range = 65-97) from the Geriatric Evaluation and Rehabilitation Unit (GERU) at P. Richiedei Hospital in Gussago, Brescia (Italy). Patients consecutively admitted to the GERU during an 18-month period underwent a multidimensional evaluation including information on demographics, cognitive status, physical health (number of chronic diseases and administered drugs), functional disability, and nutritional status. Mean cholesterol levels were significantly lower in men; persons living with others; older individuals; and individuals with cognitive impairment, poorer somatic health, higher disability, and a higher level of malnutrition. Lower serum cholesterol levels may be considered an independent hematologic marker of frailty in elderly hospitalized patients.

Aged↗
PubMedDate not supplied

Primary carcinoid tumor of the ovary: report of an unusual case.

Carcinoid tumors are endocrine malignancies that are often associated with a characteristic syndrome, the malignant carcinoid syndrome, which is most common in patients with small bowel tumors and liver metastases. In the rare instances when the syndrome is present without liver metastases the primary tumor is usually localized to the bronchus or ovary and secretes hormones directly into the systemic circulation. About two thirds of patients with carcinoid syndrome have evidence of carcinoid heart disease. We report on a case of a primary ovarian carcinoid tumor with an unusual clinical presentation.

Aged↗