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Biomedical subjects

R Royer

Publications and source records attributed to R Royer.

At least 55 records · Page 3Linked to original sources
PubMed1981

Inhibition of DNA synthesis in relation to enhanced survival of UV-damaged herpes virus in monkey cells treated by a variety of 2-nitronaphthofurans.

Various 2-nitronaphthofuran derivatives (related to each other by simple structural modifications) were tested for 2 different effects in CV-1 monkey kidney cell cultures: the immediate inhibition of normal DNA synthesis and the capacity of pretreated cultures (40 h of contact) to support the replication of UV-damaged Herpes simplex virus (HSV). For all compounds tested, a fair correlation was found between their efficiencies to inhibit cellular DNA synthesis and to provoke an increase in UV-HSV production (virus reactivation). Virus reactivation was due to an increase in both the number of virus-producing cells and the amount of infectious particles produced per cell. The most efficient 2-nitronaphthofurans (particularly 2-nitro-7-methoxy-naphtho[2,1-b]furan-R 7000) were at least as potent as aflatoxin B1 in inducing virus reactivation.

Animals↗
PubMed1981

[Cytostatic action of 2-nitronaph-thofurans on L1210 murine leukemia cells in semi-solid médium (author's transl)].

The cytostatic effect of various derivatives of 2-nitro-naphthofurans has been determined in vitro on L1210 leukemia cells. A recently described new bio-assay (Discotest) was used, which consists in plating the cells in soft agarose and placing on top of the agarose layer a paper disc soaked with the compound to be tested. The halo of inhibition of colony formation which results from diffusion of the compound is proportional to the logarithm of the compound concentration. The most active derivatives were the 2-nitro-7-methoxy and 2-nitro-8-methoxy-naphtho[2,1-b] furans which are known to be highly bactericidal and protozoocidal.

Animals↗
PubMed1976

[Nosographic approach of heriditary myopathies. Attempt at classification and diagnosis by means of erythrocyte cholinesterase and serum pseudocholinesterase analysis].

An original biological study involving assessment of red cell cholinesterase and serum pseudo-cholinesterase activity has given the authors a new approach to the classification of progressive muscular dystrophy: as a result, it has become possible to isolate Duchenne dystrophy and the carries of this disease and to distinguish them from cases of Becker's disease. Also, Leyden-Möbius dystrophy appears to deserve the name as it differs from limb-girdle dystrophy. Finally, there is a case to be made for classifying separately, because of its special biological characteristics, Steinert's myotonic dystrophy.

Butyrylcholinesterase↗