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Biomedical subjects

R Roth

Publications and source records attributed to R Roth.

84 records · Page 5Linked to original sources
PubMed1970

DNA synthesis during yeast sporulation: genetic control of an early developmental event.

In yeast the mating type alleles a and a also control sporulation; heterozygous strains (a/a) sporulate while homozygous strains (a/a or a/a) do not. Net DNA synthesis, an early event preceding sporulation, occurred normally in the heterozygous strains but did not occur in the homozygous strains. Therefore, the a/a allelles also influence early development well before spore formation begins.

Culture Media↗
PubMed1970

Carbohydrate accumulation during the sporulation of yeast.

The sporulation of Saccharomyces cerevisiae is characterized by an increase in dry weight without cell division. At least 67% of the dry weight increase is due to the synthesis of cellular carbohydrates consisting of trehalose and insoluble components. The insoluble carbohydrates accumulate only during the period preceding the actual formation of visible ascospores. The trehalose accumulates throughout the sporulation cycle and is specifically localized in the ascospore.

Carbohydrates↗
PubMedDate not supplied

Morbidity, mortality, and albuminuria in type 2 diabetic patients: a three-year prospective study of a random cohort in general practice.

In a 3-year prospective study, the prevalence of albuminuria and its relationship to macrovascular disease, pre-existing vascular risk factors and mortality rate were studied in a random cohort of 290 patients with Type 2 diabetes mellitus in general practice. Newly occurring micro- or macroalbuminuria was associated with significantly (p less than 0.05) higher systolic blood pressure: median (IQ range) 157 (140-170) vs 150 (130-160) mmHg, in addition to higher serum triglycerides: median (IQ range) 2.71 (1.84-4.25) vs 1.84 (1.35-3.14) mmol l-1, and C-peptide levels: median (IQ range) 1.30 (0.98-2.16) vs 1.10 (0.82-1.58) nmol l-1, at 3-year follow-up. Patients with macroalbuminuria at final examination had significantly higher systolic and diastolic blood pressure, serum triglyceride and beta 2-microglobulin levels, decreased HDL-cholesterol, and a significantly higher prevalence of carotid artery stenoses and peripheral vascular disease. Patients dying from vascular causes showed significantly higher urinary albumin levels at entrance as compared to the surviving patients: median (IQ range): 42.2 (11-249.7) vs 10.4 (4.6-28.0) mg l-1, p less than 0.008, and overall mortality rate was significantly linked with the presence of macroalbuminuria (26% vs 5% in normoalbuminuric patients). A comparison between the results of the initial and the final examination indicated an overall worsening of renal variables (albuminuria: median (IQ range): female 9.5 (4.5-21) vs 13.4 (5.1-39.7) mg l-1, (p less than 0.05); male 13.8 (4.7-34.1) vs 32.6 (8.1-78.7) (p less than 0.001), despite a significant improvement in metabolic variables.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗