Search PubMed⌕ Search

Biomedical subjects

R Rosenfeld

Publications and source records attributed to R Rosenfeld.

117 records · Page 7Linked to original sources
PubMedDate not supplied

A fast algorithm for searching for molecules containing a pharmacophore in very large virtual combinatorial libraries.

We present a new algorithm for identifying molecules that display a pharmacophore, or in general a structural motif, by efficiently constructing and screening huge virtual combinatorial libraries of diverse compounds. The uniqueness of this algorithm is its ability to build and screen libraries of ca. 10(18) 3D molecular conformations within a reasonable time scale, thereby increasing the chemical space that can be virtually screened by many orders of magnitude. The algorithm may be used to design new molecules that display a desired pharmacophore on predefined sets of chemical scaffolds. This is demonstrated herein by screening a library of backbone cyclic peptides to find candidate peptido- and proteinomimetics.

Algorithms↗
PubMedDate not supplied

Hypogonadism and Leydig cell hypoplasia unresponsive to human luteinizing hormone (hLH).

A 22-year-old man with hypogonadism, Leydig cell hypoplasia, high plasma LH, and normal plasma FSH was given human chorionic gonadotropin (hCG) and human luteinizing hormone (hLH) in order to assess testicular testosterone responses to exogenously administered gonadotropins. The maximal testosterone level detected after six doses of hCG, 5000 IU per dose given intramuscularly (IM) was 256 ng/dl. After eight doses of hLH, 550-1100 IU per dose given IM, the plasma testosterone level was unchanged, 100-200 ng/dl. The lack of a response to exogenously administered gonadotropins in our patient suggests that there is a primary testicular lesion causing the hypogonadism. Our patient's own LH is probably biologically active since there was no response to human LH, a pituitary extract with a known biopotency (LER 1549). Our patient's endocrine abnormality is apparently another facet in the spectrum of findings described in patients with Leydig cell hypoplasia or aplasia. Other features of this entity can include female pseudohermaphroditism, ambiguous genitalia, hypogonadism, delayed puberty, and the presence of biologically inactive LH.

Adult↗