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Biomedical subjects

R Roopnarinesingh

Publications and source records attributed to R Roopnarinesingh.

6 recordsLinked to original sources
PubMed2006

Homocysteine in assisted reproduction: does oestradiol influence homocysteine levels?

Steroid hormones including oestradiol have been identified as non-genetic factors that may influence plasma homocysteine. In advanced assisted reproduction, plasma oestradiol levels fluctuate markedly during the treatment cycle starting with normal followed by sub- and then supra-physiological levels. Because of the diverse harmful effects that hyperhomocysteinaemia has been associated with, it is imperative to understand how it may be manipulated during assisted reproduction. A total of 30 women undergoing treatment for infertility were recruited and followed through an advanced assisted reproduction cycle. Blood samples were analysed for oestradiol, homocysteine, vitamin B12, red cell folate and plasma folate during each phase. All patients had normal vitamin B12 and folate levels. Predictably, oestradiol showed marked changes as patients progressed through each treatment phase. However, there were no corresponding significant fluctuations in plasma homocysteine. Oestradiol concentration does not influence plasma homocysteine in women with normal vitamin B12 and folate levels undergoing advanced assisted reproduction.

Adult↗
PubMed2004

Choriocarcinoma-presenting as a primary lesion of the cervix.

A 25 year old nulliparous Russian lady presented to the hospital complaining of abdominal pain and mild vaginal bleeding. In 1999 she was diagnosed with a molar gestation and required a dilatation and curettage. On this occasion, Beta human Chorionic Gonadotrophin (BhCG) levels were elevated and a trans-vaginal ultrasound scan suggested the presence of a left-sided pelvic mass. Investigations confirmed the presence of a choriocarcinoma of the cervix. Complete assessment by a multidisciplinary team was performed and chemotherapy (methotrexate) was commenced. This case of a twenty-five year old nulliparous woman highlights the importance of appropriate follow-up in cases of irregular genital tract bleeding with a past history of trophoblastic disease.

Adult↗
PubMed2003

Detecting mood disorders in men diagnosed with cancer who seek semen cryopreservation: a chance to improve service.

UNLABELLED: To assess the prevalence of mood disorders in patients diagnosed with cancer and who pursue fertility preservation. Prospective questionnaire. The Human Assisted Reproduction (H.A.R.I.) unit, Rotunda Hospital. Twenty nine men were recruited between August 2001 and January 2002. Patients were informed about the study and requested to sign a consent form prior to completing the Hospital Anxiety and Depression Scale (HADS). Information regarding the patients diagnosis and prognosis were obtained from a standard referral form completed by the referring oncologists. The prevalence of mood disorders and to determine if this is related to the pretreatment prognosis. Anxiety was diagnosed in 44.8% and depression in 17.2% of patients. However clinically significant anxiety and depression was diagnosed in 13.8% and 6.9% respectively. There was no significant difference in the scores for anxiety and depression in the good prognosis group compared with the guarded group. Reduced sperm count was diagnosed in 26.9% of men and decreased motility in 30.8%, but neither of these were influenced by mood. CONCLUSION: Anxiety and depression are commonly encountered in patients with cancer. Most cases are of mild to moderate severity. Knowledge of our patients' psychological status will contribute to an improved service.

Adolescent↗
PubMed1996

Maternal deaths associated with caesarean section.

Twelve Caesarean section-associated maternal deaths were encountered over a 15-year period. The major operative risk factors were pregnancy-induced hypertension, obesity and general anaesthesia. Severe preeclampsia was the forerunner to postoperative cardiac failure, consumptive coagulopathy and difficult airway manipulation. We conclude that pregnancy-induced hypertension and its ramifications pose the greatest threat to maternal survival from a Caesarean section.

Adolescent↗
PubMedDate not supplied

An assessment of mood in males attending an infertility clinic.

This study was undertaken to assess the mood profile in men seeking treatment for infertility and also to investigate if aetiological factors of infertility have any impact on mood. This was a prospective questionnaire study and the setting was the Human Assisted Reproduction Ireland (H.A.R.I.) unit in the Rotunda Hospital. Fifty men participated in the study and were required to complete the Hospital Anxiety and Depression Scale (HADS) questionnaire. The results were analysed using an ordered logit regression analysis on the statistical software package DATA DESK 5.0.1. There were no cases of depression in the study population. However, detectable anxiety levels were displayed in 31.9% of men. Those with severe oligospermia had a higher mean anxiety score (8.5) compared with other patient subgroups. Clinically significant anxiety was found in 8.5%; all of these men had a male-factor problem. The study population was relatively small but some interesting trends were observed. A larger trial is warranted to assess if genuine at-risk groups exist.

Anxiety↗