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Biomedical subjects

R Roemer

Publications and source records attributed to R Roemer.

43 records · Page 3Linked to original sources

A dynamic two-dimensional phantom for ultrasound hyperthermia controller testing.

A new thin layer phantom for testing hyperthermia controllers has been constructed and evaluated using an ultrasound hyperthermia system. The phantom's thermal behaviour agrees with the characteristics of the Pennes' bio-heat transfer equation (BHTE). In particular, the experimental and theoretical results agree in the following ways. First, with respect to the power deposition: for a given power magnitude and scan radius, the shape of the temperature distribution across the phantom corresponds to the shape predicted by the BHTE and the experimental and theoretical temperature values agree closely; when the power magnitude is varied at a fixed scan radius, the average temperature of the phantom varies linearly with the applied power, and as the scan radius is varied at a fixed power magnitude, the average temperature increases with decreasing scan radius size. Secondly, with respect to perfusion: increasing or decreasing the flow rate over the phantom simulates an increase or decrease in the BHTE perfusion term, and the estimated perfusion values are dependent on flow rate only, and are not functions of power or geometry. The combination of these experimental and theoretical results validate the phantom's potential for testing feedback control systems, particularly for future use in the development and verification of model-based controllers. The use of this phantom should improve and accelerate the testing and evaluation of feedback control systems, and reduce the need for animal and human testing.

Animals↗

An ultrasound window to perform scanned, focused ultrasound hyperthermia treatments of brain tumors.

A series of calculations and tests were performed on polyethylene, polystyrene, acrylic, and a commercially available polymethyl methacrylate cranioplastic to determine which material would best serve as an acoustical window in the skull. The purpose of the window is to transmit focused ultrasound to treat brain tumors with hyperthermia. Each material was evaluated based on its ability to transmit power and to protect the brain. The results revealed that, of the four materials tested, polyethylene transmitted the largest percentage of incident power and is the toughest and best suited material to protect the brain. Further physical tests showed that a polyethylene plate does not significantly distort the sound field. Finally, acute and chronic dog tests (supported by theoretical calculations) using the polyethylene as an acoustical window through the skull showed that it will not reach temperatures greater than the target hyperthermia temperature (42 degrees C) at the required intensity levels unless the tumor is near the skull and the skin surface is not cooled. Since polyethylene effectively transmits power without distorting the sound field of overheating in dog tests, it may now be used in Phase 1 clinical ultrasound hyperthermia tests on human patients. However, the chronic animal studies indicated that the collagen which composes the dura thickens under the cranioplasty and absorbs increasingly greater amounts of power with time. A thick layer of organized fibrous tissue also formed on the external surface of the cranioplasty, filling in the cavity formed by the exterior surface of the cranioplasty and by the excision of the temporalis muscle.(ABSTRACT TRUNCATED AT 250 WORDS)

Acrylic Resins↗

A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments.

A commercial diagnostic ultrasound scanner (Octoson) was modified for performing hyperthermia treatments. The temperature elevations were induced in tissues by four large, focused ultrasonic transducers whose common focal zone was scanned along a computer controlled path as determined from B-scan images. The system is described and the results of preliminary tests demonstrating some of its capabilities are given. Extensive tests with canine thighs and kidneys were performed. The blood flow to the kidneys was controllable, and thus tumours having different blood perfusion rates could be simulated. The results showed that the system is capable of inducing a local temperature maximum deep in tissues (up to 10 cm was tested) and that tissues with high perfusion rates could be heated.

Animals↗

Sex education laws and policies.

Sex education laws and policies are important in facilitating or blocking efforts to provide adolescents with sexuality education and information. Legislation in developing and industrialized countries concerns both sexuality education in schools and adolescents' access to information on contraception and abortion. Although laws and policies vary, the trend is to remove laws restricting sex education and information and to promote the flow of reproductive health information for adolescents. The integration of sex education with programs that provide contraceptive services offers the promise of preventing unwanted pregnancy in adolescents, with its all too frequent tragic health and social consequences.

Adolescent↗

Legislation on contraception and abortion for adolescents.

The serious health and social consequences of adolescent pregnancy call for the examination of the laws that affect adolescents' access to contraception and abortion. The general law of any country relating to the availability, sale, or distribution and financing of contraceptives affects adolescents. Similarly, a country's general law on abortion applies to adolescents faced with unwanted pregnancy and affects them accordingly. In addition, special legislation relating to adolescents, particularly legislation or court decisions concerning parental consent for contraception or abortion for a minor, has an important influence on the access that sexually active young people have to services.

Abortion, Legal↗

A year of living dangerously: the tobacco control community meets the global settlement.

Momentum toward Congressional action on tobacco issues began with the announcement in June 1997 of a proposed "global tobacco settlement" between the tobacco industry, a group of state Attorneys General, and private class action lawyers. For the next year, tobacco issues received unprecedented national attention, culminating in the U.S. Senate's consideration and ultimate defeat of the McCain tobacco bill. Through the proposed settlement, the Attorneys General and others involved in talks with the industry sought to reduce tobacco use by attempting to forge a "win-win" solution for all parties. In exchange for money and public health concessions, the industry would be granted sweeping protection from litigation and thus a stable environment in which to operate. Members of the public health community responded to the "global tobacco settlement" in very different ways. The authors explore how different visions of possibilities and practicalities were played out in the fight for strong Federal tobacco control legislation and attempt to draw lessons for the future.

Humans↗