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Biomedical subjects

R Rodrigues

Publications and source records attributed to R Rodrigues.

At least 55 records · Page 3Linked to original sources
PubMed1987

Subaortic fibrous ridge and ventricular septal defect: role of septal malalignment.

The purpose of this study was to test the hypothesis that the presence of a subaortic ridge associated with a ventricular septal defect (VSD) is related to a malaligned ventricular septum caused by anterior or posterior deviation of the infundibular septum with or without obstructive lesions of the aortic arch. Thirty-two of 295 patients in whom a diagnosis of VSD was made by two-dimensional echocardiography and who were studied from June 1983 to April 1985 presented with a subaortic shelf. Every patient (p less than .00001) had a malalignment type of defect; the defect was produced by anterior deviation of the outlet septum (without compromise of the right ventricular outflow tract) in 28 and by posterior deviation of the infundibular septum in four. The prevalence of a subaortic shelf in the malalignment VSD group was 82% (32/39). Among the 28 patients with a subaortic ridge and anterior deviation of the outlet septum only three had aortic coarctation, but all four patients with subaortic stenosis and posterior infundibular malalignment had obstructive lesions of the aortic arch--coarctation in three and interruption of the aortic arch in one (p less than .001). We conclude that a malalignment type of VSD may be a consistent feature in patients with VSD and associated discrete subaortic stenosis. We also noted a high prevalence of subaortic ridge in the presence of a malalignment VSD and therefore speculate that there may be a common morphogenesis for malalignment VSD, subaortic shelf, and obstructive lesions of the aortic arch.

Adolescent↗
PubMed1985

Prime number variant of concealed trigeminy.

A 53-year-old man with myocardial infarction was found to have frequent premature ventricular beats. The predominant pattern was classical concealed trigeminy; i.e., the number of conducted sinus beats, S, between extrasystoles satisfied the equation S = 3n + 2, where "n" is zero or any positive integer. Two other transient patterns also occurred. The first one was characterized by exceptional values of S, which satisfied the equation S = 3n + 3. In the second transient pattern, all values of S fitted the classical equation, but there were singularly absent values; i.e., the "n" in the equation was exclusively an odd number, giving rise to only prime numbers of interectopic conducted sinus beats. It is proposed in this last form that there are two sites of fixed block proximal to a variable distal block in a re-entry loop responsible for the ventricular extrasystoles.

Biometry↗
PubMed1981

Constriction of human umbilical artery induced by local anesthetics.

In order to study the direct effects of local anesthetics on the umbilical artery, an in vitro perfusion technique, utilizing 3-cm segments of human umbilical artery obtained within 15 min of delivery, has been developed. Basal perfusion pressure (tonus) and the frequency of phasic contractions were determined in 37 arterial segments perfused for 240-min periods with Tyrode's solution containing lidocaine in concentrations of 2.0, 8.0 or 16 microgram/ml of bupivacaine in concentrations of 0.25 or 9.8 microgram/ml. A control group consisting of 11 arterial segments was perfused only with Tyrode's solution. The lowest concentration of each anesthetic approximated that reportedly present in the umbilical arteries following administration of epidural anesthesia during labor. Both lidocaine and bupivacaine induced dose-related increases of up to 100% in tonus above the control levels of approximately 60 mm Hg, statistically significant (p less than 0.05) except for 2 microgram/ml lidocaine. At the same molar concentration, bupivacaine was more effective than lidocaine (p less than 0.05). Both anesthetics also increased the frequency of phasic contractions. These data suggest that these agents may exert their effects on the fetus, at least in part, through a direct constricting action on the umbilical artery.

Bupivacaine↗