Search PubMed⌕ Search

Biomedical subjects

R Rentsch

Publications and source records attributed to R Rentsch.

9 recordsLinked to original sources
PubMed1997

[Optimizing the distribution and test locations in statistical perimetry. Preliminary results].

BACKGROUND: Are short programs useful to glaucoma-screening? We investigated the concept of Program G1x with Octopus 1-2-3, which permits examination of various numbers of test locations i.e., 16, 32, 45, or all 59 test locations. PATIENTS AND METHODS: Using 99 visual fields of glaucomatous or glaucoma-suspect right eyes, we compared mean defect (MD) and loss variance (LV) of the global visual field with MD and LV of the stages of G1x-program (standard strategy). RESULTS: The results showed that stage 1 of Program G1x underestimated the glaucomatous visual field damage present in the entire field. CONCLUSIONS: Thus, the use of only the first stage (16 test locations) of G1x is not advisable. At least 32 test locations, i.e., stages 1 and 2 of program G1x, are recommended for clinical perimetry.

Adult↗
PubMed1995

Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers.

The association between corticosteroid treatment and gastric ulcer healing is controversial. The effects of corticosteroids on experimental ulcer healing in the rat were studied and the effect of coadministration of a prostaglandin E1 analogue was determined. Forty male adult rats were divided into five groups and pretreated for 10 days as follows: (a) control, (b) prednisolone (10 mg/kg), (c) prednisolone and misoprostol (300 micrograms/kg), (d) misoprostol, and (e) indomethacin (2 mg/kg) Gastric ulcer was induced by applying a cryoprobe to the serosal surface of the stomach. Healing was assessed by determining the ulcer size at three and six days. Mucosal regenerative activity at the ulcer edge was assessed by quantitating DNA synthesis in cells by immunohistochemical techniques using monoclonal antibodies to detect expression of proliferating cell nuclear antigen (PCNA) and incorporated 5-bromo-5-iododeoxyuridine (BrdU). Compared with control rats, the rate of healing and the mucosal regenerative activity were significantly reduced in rats treated with prednisolone and indomethacin (p < 0.05). Coadministration of misoprostol and corticosteroids reversed the delay in healing and the reduction in mucosal regeneration induced by corticosteroids alone. With misoprostol alone, the ulcer size and the number of epithelial cells that actively synthesised DNA did not differ from control animals. A comparison between the two immunohistochemical markers of cell proliferation showed a highly significant correlation between the two techniques (r = 0.64, p < 0.005), indicating that the simpler PCNA technique should prove valuable in assessing regeneration in experimental ulcer disease.

Animals↗
PubMed1993

Clinical implications of liver biopsy findings in collagen-vascular disorders.

We surveyed over a 5-year period liver abnormalities in all patients with collagen-vascular disorders in whom liver histology was obtained, including 46 patients with systemic lupus erythematosus, rheumatoid arthritis, primary Sjogren's syndrome, periarteritis nodosa, mixed cryoglobulinemia, Wegener's granulomatosis, systemic sclerosis, and other conditions. Histological appearances diagnostic of the primary condition were only found in three patients, each of whom had periarteritis nodosa. Significant chronic liver disease was found in 11 patients (24%), in five of whom a strong clinical suspicion of severe chronic liver disease already existed. Clinically inapparent but potentially significant chronic liver disease was found predominantly in patients with mixed cryoglobulinemia or sicca syndrome. Seventeen percent of all biopsies suggested drug induced hepatitis. In patients with collagen-vascular diseases and abnormal liver function tests, histological examination of the liver is most frequently of value in indicating drug-induced liver damage. Significant chronic liver disease is common but usually clinically apparent. In patients with periarteritis nodosa and mixed cryoglobulinemia, liver biopsy may be of value diagnostically, revealing serious liver disease with prognostic and therapeutic implications.

Biopsy↗
PubMed1992

Steroid ulcers.

Explore the source record for details and available documents.

Animals↗
PubMed1987

[Problems of instituting insulin therapy in advanced age].

The population of diabetics of a district was analysed concerning the age structure, the proportion of the insulin-dependent patients as well as the insulin-dependent diabetics older than 60 years were analysed with regard to the degree of the realization of insulinisation. 13.8% of all diabetics with an age older than 60 years are insulin-dependent. In 71.5% of them the insulinisation is realized. Only in 43% of all insulin-dependent older diabetics an autoinjection of insulin is possible. The results are discussed and propositions for changing the situation are submitted.

Aged↗
PubMed1985

[Significance and scope of interdisciplinary cooperation in the specialty of internal medicine (inpatients)].

In a department of internal medicine of a district hospital all consultations given by representatives of non-internal medical specialties and by specialized or highly specialized representatives of the subject of internal medicine in a period of five months were registered. In 29% of all patients attended in the period of observation consultation achievements were demanded. 65% of these achievements could be realized by physicians working in hospitals or outpatient departments of the district. 23% of the consultations were carried out by specialists from institutions conducted by county authorities. 11% of the consultations were carried out by highly specialized physicians of university clinics and academy institutes. The investigation confirms the high significance of the inter-disciplinary cooperation for the subject of internal medicine. cooperation for the subject of internal

Female↗
PubMedDate not supplied

IUPAC collaborative trial study of a method to detect genetically modified soy beans and maize in dried powder.

This paper presents results of a collaborative trial study (IUPAC project No. 650/93/97) involving 29 laboratories in 13 countries applying a method for detecting genetically modified organisms (GMOs) in food. The method is based on using the polymerase chain reaction to determine the 35S promotor and the NOS terminator for detection of GMOs. reference materials were produced that were derived from genetically modified soy beans and maize. Correct identification of samples containing 2% GMOs is achievable for both soy beans and maize. For samples containing 0.5% genetically modified soy beans, analysis of the 35S promotor resulted also in a 100% correct classification. However, 3 false-negative results (out of 105 samples analyzed) were reported for analysis of the NOS terminator, which is due to the lower sensitivity of this method. Because of the bigger genomic DNA of maize, the probability of encountering false-negative results for samples containing 0.5% GMOs is greater for maize than for soy beans. For blank samples (0% GMO), only 2 false-positive results for soy beans and one for maize were reported. These results appeared as very weak signals and were most probably due to contamination of laboratory equipment.

Agrobacterium tumefaciens↗