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Biomedical subjects

R Reisenauer

Publications and source records attributed to R Reisenauer.

At least 37 records · Page 2Linked to original sources

Iodine metabolism in mothers of children with cleft lip and/or palate anomaly and in persons with endemic goitre.

The authors examined 106 subjects with simple goitre and 18 hyperthyroid subjects who themselves or their ancestors came from endemic areas, furthermore 31 mothers of children with cleft lip and/or palate and 50 subjects acting as controls. The biochemical indicators in endemic goitre were at the borderline of hypothyroidism, in mothers of children with clefts on the borderline of hyperthyroidism. The authors conclude that genetically conditioned endemic mild thyroid hypofunction still persists in our population nad that it must be taken into consideration during the examination and treatment of thyropathies. The thyroid metabolism of mothers of children with cleft lip and/or palate differs significantly in many indicators from the endemic group and preconceptional and early prenatal prevention should be focused on elimination of possible marginal hyperthyroidism. The necessity to examine the thyroid metabolism of the mother as part of preconceptional genetic care was confirmed by these results.

Adult↗

Plasma renin activity in men with relation to the presence of ischaemic heart disease.

Plasma renin activity (PRA) stimulated by upright posture was measured, in 300 men aged 45-64 years, by a radio-immunoassay of angiotensin I. The subjucts examined were divided into six groups, comparable in mean age, each containing 50 subjects: group 1, normotensives without manifest atherosclerosis; group 2, normotensives with angina pectoris definite; group 3, normotensives with a history of a transmural myocardial infarction; groups 4 to 6, patients with benign essential hypertension, without manifest atherosclerosis in group 4, with angina pectoris in group 5 and with a history of myocardial infarction in group 6. Significant differences in mean PRA were found between corresponding groups of hypertensives and normotensives, the values in hypertensives being lower. The precentage of low renin values was higher in hypertensives with ischaemic heart disease than in other groups. An analysis of 3-year cardiovascular mortality revealed no significant difference in mortality due to ischaemic heart disease between high-renin and low renin sub-groups.

Blood Glucose↗

Acute effect of large doses of calcitonin on calcium, magnesium and inorganic phosphate levels in rat serum in correlation to differences in thryroid function.

The acute effect of pharmacological doses of porcine calcitonin were studied on the calcium, inorganic phosphorus and magnesium level in correlation to thyroid function in experimental rats. In every case, and with all three doses, the serum calcium and inorganic phosphorus level fell significantly within 60 minutes after calcitonin administration. The drop in both minerals was most pronounced in the group with experimental hyperthyroidism, in which all different doses had the same effect. In experimental hypothyroidism, the decrease was correlated to the dose. In the case of the serum magnesium level, a statistically significant drop was observed in animals with hyperthyroidism after the two largest doses of calcitonin, while only a mild increase occurred in animals with hypothyroidism after the smallest dose. None of the doses of calcitonin affected the magnesium level in animals with normal thyroid function.

Animals↗