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Biomedical subjects

R Reif

Publications and source records attributed to R Reif.

At least 73 records · Page 4Linked to original sources
PubMed1980

An analysis of the factors associated with respiratory distress syndrome in premature infants whose mothers had been given dexamethasone therapy.

The incidence of respiratory distress syndrome (RDS) in 259 premature infants whose 218 mothers had received antepartum dexamethasone therapy was 8.9 per cent. The main characteristics of those infants who developed RDS were a shorter gestational age and a lower Apgar score at delivery; all were delivered before 35 weeks gestation, and those with Apgar scores below 7 had a significantly higher incidence of RDS. The incidence of RDS in vaginal breech deliveries (15.4 per cent), Caesarean sections (14.6 per cent), and multiple births (16.0 per cent) was higher than in vaginal vertex deliveries (6.8 percent), and in singletons (6.0 per cent). The use of isoxsuprine and the length of time membranes were ruptured before delivery were unrelated to the incidence of RDS. The results of this study suggest that while maternal glucocorticoid administratioin is an important ancillary to the prevention of RDS in premature infants it cannot substitute for optimal delivery conditions.

Apgar Score↗
PubMed1979

Autosomal recessive lipid storage myopathy (probable carnitine deficiency).

Two sisters died at the age of 17 and 19, respectively, of a myopathy with exacerbations and remissions characterised by pain and weakness of muscles which ended fatally with lactic acidosis and respiratory failure. The clinical picture was very similar to that described in some cases of carnitine deficiency and the histochemical finding of many lipid-filled vacuoles in muscle fibres and the electron microscopical findings were identical to those reported in that disease. The finding of affected sisters supports autosomal recessive mode of inheritance.

Adolescent↗
PubMed1977

Severe lower limb malformation associated with other deformities and death in infancy in two brothers.

Two brothers with severe and rare lower limb malformations but normal upper limbs are described. Both brothers had glans hypospadias and they died in early infancy. In the first brother the limb malformation was a severe deformity of the right foot which was split and of rockerbottom shape with oligosyndactyly. In the second brother the right limb below the knee was more severely deformed while only the toes were involved in the left limb. Details of the clinical and pathological findings are described. The most likely mode of inheritance of this rare syndrome is autosomal recessive or X-linked recessive with variable expressivity.

Abnormalities, Multiple↗
PubMed1977

Radiation-induced fibrosarcoma following treatment for breast cancer.

A patient with radiation-induced fibrosarcoma following mastectomy and postoperative radiation for bilateral breast carcinoma is described. Only six such cases have been reported in the literature. In this patient erosion of the axillary artery produced massive hemorrhage, and emergency transthoracic ligation of the subclavian artery caused gangrene of the extremity and empyema and sepsis. Interscapulothoracic amputation not only was life-saving but offered the patient a reasonable chance for long-term survival. Only aggressive surgical management can salvage a patient with radiation-induced sarcoma.

Breast Neoplasms↗
PubMed1976

Prevention of the respiratory distress syndrome in premature infants by antepartum glucocorticoid therapy.

A trial of antepartum dexamethasone therapy was carried out in 55 mothers in whom premature delivery threatned between 28 to 36 weeks gestation in the hope of reducing the incidence of respiratory distress syndromes (RDS). The control group was made up of 62 mothers who delivered prematurely in the same gestational age without any treatment. In the treated group isoxsuprine was used to delay delivery when necessary. The respiratory dif infants (8.3 per cent) than in the controls (35.2 per cent; p less than 0.001). The difference was more marked in babies of under 32 weeks gestation. Considering only cases with intact membranes the incidence of RDS was significantly (p less than 0.01) lower in the treated group. Early neonatal mortality was 6.6 per cent in the treated group and 38 per cent (p less than 0.0001) in the controls. In 12 cases the L/S ratio was measured during dexamethasone administration and in the majority of these the L/S ratio rose sharply to mature values following treatment. This rise was observed as soon as 48 hours after beginning of dexamethasone. Antepartum isoxsuprine in the treated group had no apparent effect on the incidence of RDS. No adverse effects of steroid therapy were observed. This trial confirms the studies of others that antepartum glucocorticoid can significantly reduce the incidence of RDS in premature infants.

Amniotic Fluid↗
PubMedDate not supplied

Benign angiomyoma of the uterus with unusual macroscopic appearance.

Benign mixed uterine tumors are very rare. We present a case of angiomyoma of the uterus with unusual gross appearance and diffuse polypoid growth on the uterine serosal surface. We could not find a macroscopic picture like this described in the literature.

Adult↗