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Biomedical subjects

R Reeves

Publications and source records attributed to R Reeves.

155 records · Page 9Linked to original sources
PubMed1977

Ternary copper (II) complexes containing salicylate and nitrogenous chelates such as histamine.

In the introduction the chemistry of some bivalent copper complexes of aspirin and salicylate is briefly reviewed and the biological importance of mixed-ligand complexes of bivalent copper is illustrated. The nature of hydroxy-bridged copper (II) complexes and their possible role in the physiological activity of histamine is also discussed. Several neutral, insoluble copper (II) complexes of the type (Chelate-Cu-salicylate) 0-lambda H2O where chelate = 1, 10-phenanthroline (phen), chi = 1; 2,2'-bipyridyl (bipy), chi = 2; histamine (Ha), chi = 1; and where salicylate (sal) = dianion of salicylic acid have been prepared for the first time. They have been characterised by physico-chemical methods and the role of binuclearhydroxy-bridged copper (II) complex ions in their formation is demonstrated. Such complexes may be relevant to the pharmacological action of histamine and of the salicylates, the copper complexes of which are potential anti-inflammatory drugs. Results of some in vivo experiments that have been carried out with mice are also presented.

Animals↗
PubMed1976

Ribosomal genes of Xenopus laevis: evidence of nucleosomes in transcriptionally active chromatin.

Most of the reiterated ribosomal genes in the somatic cells of larvae of a mutant of Xenopus laevis appear to be protected from short-term nuclease digestion by being packaged in the form of chromatin subunits or nucleosomes. Since these mutant animals probably require all of their ribosomal genes to be active in order to maintain viability, at least some of the transcriptionally active gene sequences are probably associated with chromatin subunits. Thus, association of DNA with nucleosomes may not necessarily preclude template activity, although such association is probably of a dynamic rather than a static nature.

Alleles↗
PubMed1976

Genomic transcriptional activity and the structure of chromatin.

Nucleic acid hybridisation has shown that micrococcal nuclease-derived chromatin subunits from the cells of Xenopus laevis contain fragments of ribosomal 28S, 18S and 5S RNAS within the population of 200 base-pair pieces of DNA. Subunits from cultured embryonic cells actively transcribing ribosomal RNA contain only 70-74% of the cistrons present in undigested wild-type DNA, while subunits from adult erythrocytes not active in RNA transcription contain close to 90% of the ribosomal cistrons in native chromatin.

Animals↗
PubMedDate not supplied

Obesity: managing comorbidities of the disease.

Obesity poses a serious health risk and is associated with a wide range of comorbid conditions. Obese patients with comorbid conditions such as type 2 diabetes and hypertension should be educated about the potential benefits of weight loss therapy. Pharmacists can offer consultative weight loss programs either on their own or by forming multidisciplinary teams with other practitioners, such as dietitians.

Humans↗